Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Alba, Guarné"'
Autor:
Michael D. Dore, Muhammad Ghufran Rafique, Tianxiao Peter Yang, Marlo Zorman, Casey M. Platnich, Pengfei Xu, Tuan Trinh, Felix J. Rizzuto, Gonzalo Cosa, Jianing Li, Alba Guarné, Hanadi F. Sleiman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein site-specific intramolecular interactions determine overall structure. Proteins then hierarchically assemble into supramolecular polymers such as microt
Externí odkaz:
https://doaj.org/article/51568a0edb0a4963a9a4a14772d6fb24
Autor:
Karina A. Stadler, Lesly J. Ortiz-Joya, Amit Singh Sahrawat, Christoph Buhlheller, Karl Gruber, Tea Pavkov-Keller, Treasa B. O’Hagan, Alba Guarné, Sergio Pulido, Marcel Marín-Villa, Klaus Zangger, Nina Gubensäk
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract According to the World Health Organization, Chagas disease (CD) is the most prevalent poverty-promoting neglected tropical disease. Alarmingly, climate change is accelerating the geographical spreading of CD causative parasite, Trypanosoma c
Externí odkaz:
https://doaj.org/article/adbb19ef198a48779d40644419993c00
Autor:
Irina R. Arkhipova, Kathleen H. Burns, Katherine B. Chiappinelli, Edward B. Chuong, Clement Goubert, Alba Guarné, Amanda M. Larracuente, E. Alice Lee, Henry L. Levin
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The conference “Transposable Elements at the Crossroads of Evolution, Health and Disease” was hosted by Keystone Symposia in Whistler, British Columbia, Canada, on September 3–6, 2023, and was organized by Kathleen Burns, Harmit Malik
Externí odkaz:
https://doaj.org/article/ea3d4033cdaa4121823068b3340dce6f
Autor:
June Ereño-Orbea, Taylor Sicard, Hong Cui, Mohammad T. Mazhab-Jafari, Samir Benlekbir, Alba Guarné, John L. Rubinstein, Jean-Philippe Julien
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The B-cell-specific co-receptor CD22 is a therapeutic target for depleting dysregulated B cells. Here the authors structurally characterize the ectodomain of CD22 and present its crystal structure with the bound therapeutic antibody epratuzumab, whic
Externí odkaz:
https://doaj.org/article/04e84326931749769862d90cdc858a46
Autor:
Diego S Ferrero, Victor M Ruiz-Arroyo, Nicolas Soler, Isabel Usón, Alba Guarné, Núria Verdaguer
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007656 (2019)
Zika virus (ZIKV), a member of the Flaviviridae family, has emerged as a major public health threat, since ZIKV infection has been connected to microcephaly and other neurological disorders. Flavivirus genome replication is driven by NS5, an RNA-depe
Externí odkaz:
https://doaj.org/article/66b88b0ff5d94d648b62c684ee14ffa1
Autor:
Peter J. Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C. Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D. Wright
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Antibiotic resistance is a major clinical problem that threatens to undermine our ability to control infectious diseases. Here the authors present detailed structural analysis of Rifampin phosphotransferase from Listeria monocytogenes, yielding insig
Externí odkaz:
https://doaj.org/article/64b0a2b6d6ba4b86bd0e1b03eb366200
Autor:
Alba Guarné, Yao Shen, Michael T. Petassi, Joaquin Ortega, Joseph E. Peters, Josué Gómez-Blanco
Publikováno v:
Nature Structural & Molecular Biology. 29:143-151
Tn7 transposable elements are unique for their highly specific, and sometimes programmable, target-site selection mechanisms and precise insertions. All the elements in the Tn7-family utilize a AAA+ adaptor (TnsC) to coordinates target-site selection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8564a216a4f23be3b76d1d1b0ec3ad
https://doi.org/10.1038/s41594-022-00724-8
https://doi.org/10.1038/s41594-022-00724-8
Autor:
Edgar Pinedo-Carpio, Julien Dessapt, Romain Villot, Lauralicia Sacre, Abba Malina, Jonathan Boulais, Elise G. Lavoie, Vincent Luo, Ana-Maria Lazaratos, Jean-François Côté, Frédérick Mallette, Alba Guarné, Amelie Fradet-Turcotte, Alexandre Orthwein
Interstrand DNA crosslinks (ICLs) represent complex lesions that block essential biological processes, including DNA replication, recombination, and transcription. Several pathways have been involved in ICL repair, in particular nucleotide excision r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::488f343a9fbd7bf5514003a9f0ad9947
https://doi.org/10.1101/2022.10.06.511186
https://doi.org/10.1101/2022.10.06.511186
Autor:
Marie-Ève Hamelin, Julie Carbonneau, Yao Shen, Christian Couture, Martin Pilaev, Chantal Rhéaume, Marie-Christine Venable, Guy Boivin, Sophie Lavigne, Alba Guarné
Publikováno v:
Vaccine. 38:2122-2127
Human metapneumovirus (hMPV) is an important respiratory pathogen especially in young children and elderly subjects. Our objective was to assess the immunogenicity and protection conferred by predominant pre- and post-fusion (F) hMPV-F constructs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f38e384f51096656dcdc1a6784a207b
https://doi.org/10.1016/j.vaccine.2020.01.047
https://doi.org/10.1016/j.vaccine.2020.01.047
Autor:
Ahmad W. Almawi, Javier Rodríguez González, Laurence Langlois-Lemay, Alba Guarné, Giuseppe Melacini, Damien D’Amours, Stephen Boulton
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Polo-like kinases (Plks) are key cell cycle regulators. They contain a kinase domain followed by a polo-box domain that recognizes phosphorylated substrates and enhances their phosphorylation. The regulatory subunit of the Dbf4-dependent kinase compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2a8d23138d1a31e8802db3ac21179f
http://link.springer.com/article/10.1038/s41598-020-60344-4
http://link.springer.com/article/10.1038/s41598-020-60344-4