Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alayne Brunner"'
Autor:
Jennifer Cain, Fiore Cattaruzza, Alayne Brunner, Marcus Fischer, Min Wang, Timothy Hoey, James W. Evans, Belinda Cancilla, Christopher Murriel, Ann M. Kapoun, Wan-Ching Yen, Gilbert O'Young, Rajaa Hussein, V. Pete Yeung
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). The R-spondin (RSPO) family is a group of secreted proteins that enhance Wnt signaling and RSPO2 and RSPO3 gene fusions have been reported in CRC. We hav
Autor:
Ming-Hong Xie, Fumiko Takada Axelrod, Belinda Cancilla, Ann M. Kapoun, Reyhaneh Lahmy, Alayne Brunner, Jorge Monteon, Gilbert O'Young, Rose Harris, Pete Yeung, Austin L. Gurney, Andrew Lam, Fiore Cattaruzza, Earth Light Lowe, Gretchen Argast, Jennifer Elechko, Min Wang, Erwan Le Scolan
Publikováno v:
Cancer Research. 78:3826-3826
Activation of the co-stimulatory receptor GITR (Glucocorticoid-Induced Tumor Necrosis Factor Receptor) by GITR-Ligand (GITRL) promotes proliferation and activation of effector T cells (T eff) and inhibits suppressive activity of regulatory T cells (T
Autor:
Fumiko Takada Axelrod, Rose Harris, Austin L. Gurney, Ming-Hong Xie, Pete Yeung, Ann M. Kapoun, Alayne Brunner, Reyhaneh Lahmy, Fiore Cattaruzza, Erwan Le Scolan, John Lewicki, Gilbert O'Young, Jorge Monteon, Andrew Lam, Belinda Cancilla, Min Wang, Earth Light Lowe, Gretchen Argast, Jennifer Elechko
Publikováno v:
Cancer Research. 78:5627-5627
The immune checkpoint co-inhibitory receptor TIGIT (T cell immunoreceptor with Ig ITIM domain) is expressed on regulatory T cells (Tregs) and on activated CD4+ T, CD8+ T, and NK cells. We have reported that by blocking TIGIT activity with an IgG2a an
Autor:
Christopher Murriel, Timothy Hoey, Belinda Cancilla, V. Pete Yeung, Ann M. Kapoun, Fiore Cattaruzza, Min Wang, Marcus Fischer, Gilbert O'Young, Alayne Brunner, James W. Evans
Publikováno v:
Cancer Research. 77:1911-1911
Introduction: Colorectal cancer (CRC) is the third most common cancer diagnosed in both men and women. Dysregulation of the WNT/β-catenin pathway is the most commonly mutated pathway in CRC. R-spondins (RSPO), a family of secreted proteins, are enha
Autor:
Min Wang, Belinda Cancilla, Erwan Le Scolan, John Lewicki, Tim Hoey, Austin L. Gurney, Pete Yeung, Fiore Cattaruzza, Gretechen Argast, Ann M. Kapoun, Yu-Wang Liu, Jennifer Cain, Gilbert O'Young, Alayne Brunner
Publikováno v:
Cancer Research. 77:599-599
TIGIT (T cell immunoreceptor with Ig ITIM domain) is a co-inhibitory receptor and its signaling axis inhibits T cell and Natural Killer (NK) cell activity in the healthy immune system. In tumors TIGIT is highly expressed on a subset of dysfunctional
Autor:
Gretchen Argast, Earth Light Lowe, Fiore Cattaruzza, John Lewicki, Pete Yeung, Min Wang, Ann M. Kapoun, Erwan LeScolan, Alayne Brunner, Belinda Cancilla, Gilbert O'Young, Yu-Wang Liu, Austin L. Gurney, Jennifer Cain, Tim Hoey, Rose Harris
Publikováno v:
Cancer Research. 77:5621-5621
GITRL (Glucocorticoid-Induced Tumor Necrosis Factor Receptor Ligand, TNFSF18) is a member of the tumor necrosis factor (TNF) ligand superfamily. GITRL binds and activates the co-stimulatory surface receptor GITR, which promotes proliferation and acti
Autor:
Cristina Dee-Hoskins, Kellie Pickell, Jakob Dupont, Roger Lopez, Gilbert O'Young, Min Wang, Austin L. Gurney, Tim Hoey, Raymond Tam, Ann M. Kapoun, Alayne Brunner, James P. Evans, Belinda Cancilla, John Lewicki, Wan-Cheng Yen, Xiaomei Song, Angie Inkyung Park, Chun Zhang, Lei Zhou, Marcus Fischer
Publikováno v:
Clinical Cancer Research. 22:A42-A42
OncoMed Pharmaceuticals is focused on discovering novel therapies that target cancer stem cells (CSCs), specifically those which depend on the Notch or Wnt pathways. Since Patient Derived Xenografts (PDXs) recapitulate both tumor cell heterogeneity a
Autor:
John Lewicki, Wan-Ching Yen, Alayne Brunner, Marcus Fischer, Austin L. Gurney, Pete Yeung, Fiore Cattaruzza, Rainer Karl Brachmann, Claire Guo, Min Wang, Chun Zhang, Ann M. Kapoun, Belinda Cancilla, Tim Hoey
Publikováno v:
Cancer Research. 76:3129-3129
Background: The WNT/ β-catenin signaling pathway has been shown to play a key role in both normal development and tumorigenesis (Polakis, 2007; MacDonald et al., 2009). We have developed a monoclonal antibody, vantictumab, that blocks canonical WNT/
Autor:
Min Wang, Ann M. Kapoun, Marcus Fischer, Tim Hoey, Alayne Brunner, Raymond Tam, Wan-Ching Yen, Pete Yeung, Fiore Cattaruzza, John Lewicki, Belinda Cancilla, Yu-Wang Liu, Gilbert O'Young, Austin L. Gurney
Publikováno v:
Cancer Research. 76:4652-4652
Background: Non-small cell lung cancer (NSCLC) accounts for the vast majority of lung cancers, the leading cause of cancer-related deaths. Notch signaling has been shown to play an important role in lung cancer initiation and progression. Delta-like
Autor:
Marcus Fischer, Wan-Ching Yen, Tim Hoey, Fiore Cattaruzza, Yu-Wang Liu, Austin L. Gurney, Ann M. Kapoun, John Lewicki, Gilbert O'Young, Cecile Chartier, Pete Yeung, Min Wang, Alayne Brunner
Publikováno v:
Cancer Research. 75:4367-4367
R-spondins (RSPOs) are a novel family of secreted ligands that bind to LGR receptors and are important in human tumor development. We screened our tumor bank of close to 100 patient-derived xenografts (PDXs) and found that a subset of breast, lung, o