Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Alayne B. Smith"'
Autor:
Mark A. Basinger, Mark M. Jones, Alayne B. Smith, Glen R. Gale, Wesley R. Harris, Pramod K. Singh
Publikováno v:
Chemical Research in Toxicology. 7:367-373
A novel method for the synthesis of monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) is presented which utilizes the reaction of the vicinal sulfhydryl-protected anhydride with the corresponding alcohol in the presence of a base. The product is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40944eb20a7bf7547d51af388f8961e5
https://doi.org/10.1021/tx00039a014
https://doi.org/10.1021/tx00039a014
Publikováno v:
Pharmacology & Toxicology. 74:76-83
Syntheses and relative cadmium mobilizing properties are described for three new monoaralkyl esters (HOOCCH(SH)CH(SH)COOR, where R = phenylethyl ((CH2)2C6H5), MPhEDMS; R = 3-phenylpropyl ((CH2)3C6H5), MPhPDMS; and R = 2-phenoxyethyl ((CH2)2OC6H5). MP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ea09ee08d8903b8e3ea70d52066782
https://doi.org/10.1111/j.1600-0773.1994.tb01079.x
https://doi.org/10.1111/j.1600-0773.1994.tb01079.x
Publikováno v:
Toxicology. 81:49-56
Seven monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) were evaluated for relative activities in mobilizing and promoting excretion of mercury in mercury-laden mice. Compounds assessed were the ethyl (M-EDMS), n-propyl (Mn-PDMS), isopropyl (Mi-P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1066465197d3618b7e1f417d0c2772b1
https://doi.org/10.1016/0300-483x(93)90155-l
https://doi.org/10.1016/0300-483x(93)90155-l
Autor:
Angie Stone, Walker Em, Pramod K. Singh, Mark M. Jones, Mark A. Basinger, Glen R. Gale, Alayne B. Smith
Publikováno v:
Archives of Toxicology. 66:713-718
Administration of N-benzyl-N-lactyl dithiocarbamate (BLDTC) to mice after chronic cadmium (Cd) administration evoked a prompt, dose-dependent reduction of the whole body burden; 75% of the retained Cd was mobilized and excreted after 20 i.p. injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3263df0a3eef4c6e297b3d2700e770
https://doi.org/10.1007/bf01972622
https://doi.org/10.1007/bf01972622
Autor:
Alayne B. Smith, Gale Gr, Lynda Beth Milligan, Mark A. Basinger, Loretta M. Atkins, Angie Stone, Mark M. Jones, Pramod K. Singh, Walker Em
Publikováno v:
Toxicology. 76:79-87
The following six monoalkyl esters of meso -2,3-dimercaptosuccinic acid (DMSA) were synthesized and evaluated for relative activities in mobilizing lead from kidneys and brains of lead-bearing mice: n -propyl (M n -PDMS), i -propyl (M i -PDMS), n -bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07917679bee465865ff036148818c6f6
https://doi.org/10.1016/0300-483x(92)90020-f
https://doi.org/10.1016/0300-483x(92)90020-f
Publikováno v:
Pharmacology & Toxicology. 70:336-343
The relative activities of a series of nine monoalkyl esters of meso-2,3-dimercaptosuccinic acid have been examined as agents for the mobilization of cadmium from mice one week after intraperitoneal administration of cadmium chloride. Eight of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb54d849cc34390cba5392896aaaa3f5
https://doi.org/10.1111/j.1600-0773.1992.tb00483.x
https://doi.org/10.1111/j.1600-0773.1992.tb00483.x
Autor:
Loretta M. Atkins, Shirley G. Jones, Mark M. Jones, James A. Banton, Glen R. Gale, Pramod K. Singh, Chetan R. Mukundan, Alayne B. Smith
Publikováno v:
Chemical Research in Toxicology. 4:27-34
The effects of three major structural features on the intracellular cadmium mobilizing potency of dithiocarbamates have been examined. These features, the chirality of the groups, the total ionic charge of the chelating agent, and the extent of chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b851722a2834c2ade1b3d4aaedf1e748
https://doi.org/10.1021/tx00019a004
https://doi.org/10.1021/tx00019a004
Publikováno v:
Toxicology and Applied Pharmacology. 106:529-535
The cadmium mobilizing properties of two newly synthesized esters of meso-2,3-dimercaptosuccinic acid in mice have been examined. They are: di(2'-methoxyethyl) meso-2,3-dimercaptosuccinate ([-CH(SH)COOCH2CH2OR]2, R = CH3; MEDMS), and di(2'-ethoxyethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdf761b3e62e659f21c28d187fb46ac
https://doi.org/10.1016/0041-008x(90)90347-w
https://doi.org/10.1016/0041-008x(90)90347-w
Autor:
Ie Macgregor, Nsm Berry, Wjf Ray, Pr Vaughan, Et Haws, Ta Johnson, R J T Casinader, Alayne B. Smith, Jw Findlay, Adm Penman, Mf Kennard, Mtt Jones, Jp Millmore, Dj Knight, G Rocke, Hs Eadie
Publikováno v:
Proceedings of the Institution of Civil Engineers. 88:155-164
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::469787f57087a22fd9588bade63d371e
https://doi.org/10.1680/iicep.1990.4666
https://doi.org/10.1680/iicep.1990.4666
Publikováno v:
Toxicology Letters. 50:85-96
A number of dosing regimens was assessed to determine the optimum schedule of administration of N -(4-methoxybenzyl)- N -dithiocarboxy- d -glucamine (MeOBDCG) in depleting whole-body, renal and hepatic levels of metallothionein-bound cadmium (Cd) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eb0fb00887428000ae459573c9b0d0
https://doi.org/10.1016/0378-4274(90)90255-k
https://doi.org/10.1016/0378-4274(90)90255-k