Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alayna M. George Thompson"'
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 335-340 (2015)
The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin‐dependant glucose metabolism through a mec
Externí odkaz:
https://doaj.org/article/f23508b4f518488f9b3144dfa2b7837c
Publikováno v:
Analytical Methods. 14:383-393
Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for characterizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8e6c0f5180d1f0217ca571831ca39c
https://doi.org/10.1039/d1ay01556g
https://doi.org/10.1039/d1ay01556g
Autor:
Gregory K. Potts, Edwin E. Escobar, Janice Lee, Damien B. Ready, Jennifer S. Brodbelt, Eleanor Watts, Alayna M. George Thompson, Melanie J. Patterson
Publikováno v:
Analytical Chemistry. 93:13134-13142
Identifying major histocompatibility complex (MHC) class I immunopeptide antigens represents a key step in the development of immune-based targeted therapeutics and vaccines. However, the complete characterization of these antigens by tandem mass spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bedb4d921a2231a465c2965763f900
https://doi.org/10.1021/acs.analchem.1c01002
https://doi.org/10.1021/acs.analchem.1c01002
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 335-340 (2015)
FEBS Open Bio, Vol 5, Iss 1, Pp 335-340 (2015)
Highlights • The antipsychotic drug olanzapine inhibits the glucose transport of a GLUT4 homologue. • Olanzapine binds in a newly discovered site at the cytosolic side of the glucose transporter. • Olanzapine inhibits the glucose transporter by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcb7e120850424398c8655970a8a978
https://doi.org/10.1016/j.fob.2015.04.006
https://doi.org/10.1016/j.fob.2015.04.006
Autor:
Ace George Santiago, Won Jung, Peng Chen, Megan M. McEvoy, Lauren A. Genova, Alayna M. George Thompson, Tai-Yen Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 26
Multicomponent efflux complexes constitute a primary mechanism for Gram-negative bacteria to expel toxic molecules for survival. As these complexes traverse the periplasm and link inner and outer membranes, it remains unclear how they operate efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217e17ee8483bb7c21139d4bbeb64e06
https://pubmed.ncbi.nlm.nih.gov/28607072
https://pubmed.ncbi.nlm.nih.gov/28607072
Publikováno v:
Scientific Reports
Salicylic acid (SA) is a signaling molecule utilized by plants in response to various stresses. Through conjugation with small organic molecules such as glucose, an inactive form of SA is generated which can be transported into and stored in plant va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51505ee4067fabf427783d576ec33d9f
Publikováno v:
Journal of Biological Chemistry. 289:20492-20501
Cellular copper homeostasis requires transmembrane transport and compartmental trafficking while maintaining the cell essentially free of uncomplexed Cu2+/+. In bacteria, soluble cytoplasmic and periplasmic chaperones bind and deliver Cu+ to target t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86bcdee45a09e52a1332a1941400577
https://doi.org/10.1074/jbc.m114.577668
https://doi.org/10.1074/jbc.m114.577668
Autor:
Thi Thanh Hanh Nguyen, Jun-Yong Choe, Doman Kim, Cristina V. Iancu, Alayna M. George Thompson
Publikováno v:
Scientific Reports
SCIENTIFIC REPORTS(5)
SCIENTIFIC REPORTS(5)
Glucose transporters GLUT1 (transports glucose) and GLUT5 (transports fructose), in addition to their functions in normal metabolism, have been implicated in several diseases including cancer and diabetes. While GLUT1 has several inhibitors, none hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e8d5b30b099ce1135f530ea8415df6
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8f7c6bf9acc9a7b780a108b5221ff42
https://doi.org/10.1096/fasebj.29.1_supplement.884.67
https://doi.org/10.1096/fasebj.29.1_supplement.884.67
