Acute transplantation of NPC on electrospun poly-lactic acid membranes containing curcumin into the injured spinal cord reduces neuronal degeneration

Autor: María del Mar Sánchez-Martín, Esther Giraldo, Fernando Gisbert Roca, Ana Alastrue-Agudo, Cristina Martínez-Ramos, Manuel Monleón Pradas, Victoria Moreno-Manzano

Publikováno v: Frontiers in Biomaterials Science, Vol 2 (2023)

Effective spinal cord injury (SCI) treatment remains a significant challenge, given the complex nature of the primary injury and associated devastating loss of neural activity. Neural progenitor cell (NPC)-based therapy has emerged as a potent strate

Externí odkaz: https://doaj.org/article/ac8466a97ac74844a841bb8cedc6e499

tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing

Autor: Lorena de la Fuente, Ángeles Arzalluz-Luque, Manuel Tardáguila, Héctor del Risco, Cristina Martí, Sonia Tarazona, Pedro Salguero, Raymond Scott, Alberto Lerma, Ana Alastrue-Agudo, Pablo Bonilla, Jeremy R. B. Newman, Shunichi Kosugi, Lauren M. McIntyre, Victoria Moreno-Manzano, Ana Conesa

Publikováno v: Genome Biology, Vol 21, Iss 1, Pp 1-32 (2020)

Abstract Recent advances in long-read sequencing solve inaccuracies in alternative transcript identification of full-length transcripts in short-read RNA-Seq data, which encourages the development of methods for isoform-centered functional analysis.

Externí odkaz: https://doaj.org/article/43d2bfbe25f9461c9529a9f3e3a7f87d

Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery

Autor: Requejo-Aguilar, Raquel, Alastrue-Agudo, Ana, Cases-Villar, Marta, Lopez-Mocholi, Eric, England, Richard, Vicent, María J., Moreno-Manzano, Victoria

Publikováno v: In Biomaterials January 2017 113:18-30

Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation

Autor: Francisco Javier Rodriguez-Jimenez, Ana Alastrue-Agudo, Miodrag Stojkovic, Slaven Erceg, Victoria Moreno-Manzano

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 26608-26618 (2015)

Ion channels included in the family of Connexins (Cx) help to control cell proliferation and differentiation of neuronal progenitors. Here we explored the role of Connexin 50 (Cx50) in cell fate modulation of adult spinal cord derived neural precurso

Externí odkaz: https://doaj.org/article/79e1301b6b49419cbebd3c505c650e8c

NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation

Autor: Beatriz Martínez-Rojas, Esther Giraldo, Rubén Grillo-Risco, Marta R. Hidalgo, Eric López-Mocholi, Ana Alastrue-Agudo, Francisco García-García, Victoria Moreno-Manzano

Publikováno v: CELLULAR AND MOLECULAR LIFE SCIENCES
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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Neural progenitor cell (NPC) transplantation represents a promising treatment strategy for spinal cord injury (SCI); however, the underlying therapeutic mechanisms remain incompletely understood. We demonstrate that severe spinal contusion in adult r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b589e79b18121ecfdb4201c1432fdcb5
https://pubmed.ncbi.nlm.nih.gov/35904607