Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Alastair Wilkins"'
Autor:
Kevin C. Kemp, Anastasia Georgievskaya, Kelly Hares, Juliana Redondo, Steven Bailey, Claire M. Rice, Neil J. Scolding, Chris Metcalfe, Alastair Wilkins
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Work in a mouse model of Friedreich’s ataxia has shown that administration of the cytokine granulocyte-colony stimulating factor (G-CSF) could have beneficial neuroprotective effects. Here the authors perform a pilot study of Lenograstim (recombina
Externí odkaz:
https://doaj.org/article/cb7e58544e044c609b7610d1857a7b4a
Publikováno v:
AMRC Open Research, Vol 1 (2019)
Background: Early disturbances in axonal transport, before the onset of gross neuropathology, occur in a spectrum of neurodegenerative diseases including Alzheimer’s disease. Kinesin superfamily motor proteins (KIFs) are responsible for anterograde
Externí odkaz:
https://doaj.org/article/7c4b2bf47b2e4f09bc10b75112d63908
Autor:
Alastair Wilkins
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
Multiple sclerosis (MS) commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs contribute significantly to clinical disability, and symptoms such as tremor, ataxia, and dysarthria are particularly difficult to treat. Inc
Externí odkaz:
https://doaj.org/article/a99b9b9986e540989556c2abe3804890
Autor:
Kevin Kemp, Elizabeth Mallam, Kelly Hares, Jonathan Witherick, Neil Scolding, Alastair Wilkins
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26098 (2011)
Dramatic advances in recent decades in understanding the genetics of Friedreich ataxia (FRDA)--a GAA triplet expansion causing greatly reduced expression of the mitochondrial protein frataxin--have thus far yielded no therapeutic dividend, since ther
Externí odkaz:
https://doaj.org/article/3b4cc441c7f64670a46b61ccced409a5
Publikováno v:
Autoimmune Diseases, Vol 2011 (2011)
Externí odkaz:
https://doaj.org/article/833eea508ece418584922d15ec4f3aec
Autor:
Andriana Gialeli, Nicola Buckner, Liang-Fong Wong, Kevin C Kemp, Caroline A Rivers, Nicholas D. Allen, Helen L. Scott, Alastair Wilkins, Gongyu Shi, James B. Uney, Oscar Cordero-Llana
Publikováno v:
Buckner, N, Kemp, K C, Scott, H L, Shi, G, Rivers, C A, Gialeli, A, Wong, L-F, Cordero Llana, O, Allen, N, Wilkins, A & Uney, J B 2020, ' Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and huntington’s chorea ', Brain Pathology . https://doi.org/10.1111/bpa.12872
Brain Pathology
Brain Pathology
SAFB1 is a DNA and RNA binding protein that is highly expressed in the cerebellum and hippocampus and is involved in the processing of coding and non‐coding RNAs, splicing and dendritic function. We analyzed SAFB1 expression in the post‐mortem br
Autor:
Neil J Scolding, Neil Robertson, Emma C. Tallantyre, Alastair Wilkins, Kevin C Kemp, Kelly M Hares, Samantha Loveless, Claire M Rice
Publikováno v:
Journal of Neurology
Hares, K, Kemp, K, Loveless, S, Rice, C M, Scolding, N, Tallantyre, E, Robertson, N & Wilkins, A 2021, ' KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis ', Journal of Neurology, vol. 268, no. 6, pp. 2175-2184 . https://doi.org/10.1007/s00415-020-10373-w
Hares, K, Kemp, K, Loveless, S, Rice, C M, Scolding, N, Tallantyre, E, Robertson, N & Wilkins, A 2021, ' KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis ', Journal of Neurology, vol. 268, no. 6, pp. 2175-2184 . https://doi.org/10.1007/s00415-020-10373-w
There is increasing interest in the development of multiple sclerosis (MS) biomarkers that reflect central nervous system tissue injury to determine prognosis. We aimed to assess the prognostic value of kinesin superfamily motor protein KIF5A in MS b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3885e366b3fe590e9f358636ac6acc9b
Autor:
Kelly M Hares, Juliana Redondo, Andrew Herman, Helen L. Scott, Clare L Killick-Cole, Kevin C Kemp, Francesca Mills, Susan C Short, Risto A. Kauppinen, Gary Shaw, Alastair Wilkins, Lorena Sueiro Ballesteros, Heiko Wurdak, James B. Uney, Tom Batstone, Harry Bulstrode, William G B Singleton, Tim Brend, Kathreena M Kurian, Oscar Cordero-Llana, Harry R Haynes
Publikováno v:
The Journal of Pathology
Haynes, H R, Scott, H L, Killick-Cole, C L, Shaw, G, Brend, T, Hares, K M, Redondo, J, Kemp, K C, Ballesteros, L S, Herman, A, Cordero-Llana, O, Singleton, W G, Mills, F, Batstone, T, Bulstrode, H, Kauppinen, R A, Wurdak, H, Uney, J B, Short, S C, Wilkins, A & Kurian, K M 2019, ' shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth ', Journal of Pathology, vol. 247, no. 4, pp. 422-434 . https://doi.org/10.1002/path.5201
Haynes, H R, Scott, H L, Killick-Cole, C L, Shaw, G, Brend, T, Hares, K M, Redondo, J, Kemp, K C, Ballesteros, L S, Herman, A, Cordero-Llana, O, Singleton, W G, Mills, F, Batstone, T, Bulstrode, H, Kauppinen, R A, Wurdak, H, Uney, J B, Short, S C, Wilkins, A & Kurian, K M 2019, ' shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth ', Journal of Pathology, vol. 247, no. 4, pp. 422-434 . https://doi.org/10.1002/path.5201
The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcription fact
Autor:
Alerie Guzman de la Fuente, Brooke Lumicisi, Sorrel R. B. Bickley, Judy Beveridge, Ranjit Kaur, Jennifer Robertson, Patrick Camilleri, Debbie Ainslie, Alasdair Coles, Stefano Pluchino, Anna Williams, Emma Gray, Gavin Giovannoni, Luca Peruzzotti-Jametti, Denise C. Fitzgerald, Kenneth Smith, Matthew Craner, David Baker, Alan Palmer, Alastair Wilkins, Nick G Cunniffe, Khue Anh Vuong, David Kozlowski, Don J. Mahad, Alan Rothaul, Lyndsey Shellard, Lorraine Hazlehurst, Raj Kapoor, Björn Neumann
Publikováno v:
Cunniffe, N, Vuong, K A, Ainslie, D, Baker, D, Beveridge, J, Bickley, S R B, Camilleri, P, Craner, M, Fitzgerald, D C, De La Fuente, A G, Giovannoni, G, Gray, E, Hazlehurst, L, Kapoor, R, Kaur, R, Kozlowski, D, Lumicisi, B, Mahad, D, Neumann, B, Palmer, A, Peruzzotti-Jametti, L, Pluchino, S, Robertson, J, Rothaul, A, Shellard, L, Smith, K J, Wilkins, A, Williams, A C & Coles, A J 2020, ' A systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis ', Journal of Neurology, Neurosurgery & Psychiatry . https://doi.org/10.1136/jnnp-2020-324286
ObjectiveTo establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS).MethodsWe long-listed licensed drugs with evid
Autor:
Juliana Redondo, Harry R Haynes, Neil J Scolding, Alastair Wilkins, Mark A. Pook, Amelia J. Cook, Claire M Rice, Bronwen R Burton, Kevin C Kemp, Kelly M Hares
Publikováno v:
Annals of Neurology. 83:779-793
Objective Friedreich's ataxia is an incurable inherited neurological disease caused by frataxin deficiency. Here, we report the neuroreparative effects of myeloablative allogeneic bone marrow transplantation in a humanized murine model of the disease