Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Alastair O'brien"'
Autor:
Alice-Maria Toader, Marion K. Campbell, Jennifer K. Quint, Michael Robling, Matthew R Sydes, Joanna Thorn, Alexandra Wright-Hughes, Ly-Mee Yu, Tom. E. F. Abbott, Simon Bond, Fergus J. Caskey, Madeleine Clout, Michelle Collinson, Bethan Copsey, Gwyneth Davies, Timothy Driscoll, Carrol Gamble, Xavier L. Griffin, Thomas Hamborg, Jessica Harris, David A. Harrison, Deena Harji, Emily J. Henderson, Pip Logan, Sharon B. Love, Laura A. Magee, Alastair O’Brien, Maria Pufulete, Padmanabhan Ramnarayan, Athanasios Saratzis, Jo Smith, Ivonne Solis-Trapala, Clive Stubbs, Amanda Farrin, Paula Williamson
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, issues to be considered
Externí odkaz:
https://doaj.org/article/efe4d0815e14403eba11b00df3eba7e8
Autor:
Zhaohui Bai, Nahum Méndez-Sánchez, Fernando Gomes Romeiro, Andrea Mancuso, Cyriac Abby Philips, Frank Tacke, Metin Basaranoglu, Massimo Primignani, Mostafa Ibrahim, Yu Jun Wong, Filipe Gaio Nery, Rolf Teschke, Carlos Noronha Ferreira, Alberto E. Muñoz, Kanokwan Pinyopornpanish, Thierry Thevenot, Shivaram Prasad Singh, Arpan Mohanty, Sanjaya K. Satapathy, Lorenzo Ridola, Hitoshi Maruyama, Evangelos Cholongitas, Giovanni Battista Levi Sandri, Li Yang, Shalimar, Yongping Yang, Erica Villa, Aleksander Krag, Florence Wong, Rajiv Jalan, Alastair O’Brien, Mauro Bernardi, Xingshun Qi
Publikováno v:
JHEP Reports, Vol 5, Iss 8, Pp 100785- (2023)
Background & Aims: Numerous studies have evaluated the role of human albumin (HA) in managing various liver cirrhosis-related complications. However, their conclusions remain partially controversial, probably because HA was evaluated in different set
Externí odkaz:
https://doaj.org/article/b3fc9b951e9e4fe1a4eae57800e9c550
Autor:
Dominic Crocombe, Norin Ahmed, Indran Balakrishnan, Ekaterina Bordea, Marisa Chau, Louise China, Lynsey Corless, Victoria Danquah, Hakim-Moulay Dehbi, John F. Dillon, Ewan H. Forrest, Nick Freemantle, David Peter Gear, Coral Hollywood, Rachael Hunter, Tasheeka Jeyapalan, Yiannis Kallis, Stuart McPherson, Iulia Munteanu, Jim Portal, Paul Richardson, Stephen D. Ryder, Amandeep Virk, Gavin Wright, Alastair O’Brien
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Bacterial infection is a major cause of mortality in patients with cirrhosis. Spontaneous bacterial peritonitis (SBP) is a serious and common infection in patients with cirrhosis and ascites. Secondary prophylactic antibiotic ther
Externí odkaz:
https://doaj.org/article/70972166f2b641b0839902f230119dca
Autor:
Louise China, Thais Tittanegro, Dominic Crocombe, Ewan Forrest, Yiannis Kallis, Stephen D. Ryder, Gavin Wright, Nick Freemantle, Alastair O'Brien
Publikováno v:
EClinicalMedicine, Vol 58, Iss , Pp 101924- (2023)
Summary: Background: Proton pump inhibitors (PPIs) are commonly prescribed to prevent and treat upper gastrointestinal ulceration and bleeding. Studies have identified increased incidence of spontaneous bacterial peritonitis and hepatic encephalopath
Externí odkaz:
https://doaj.org/article/dc2220861621493d8a1ad11582960c15
Autor:
Thais Tittanegro, Louise China, Ewan Forrest, Yiannis Kallis, Stephen D. Ryder, Gavin Wright, Nick Freemantle, Alastair O'Brien
Publikováno v:
EClinicalMedicine, Vol 55, Iss , Pp 101716- (2023)
Summary: Background: Nonselective B-blockers (NSBBs) are believed to have pleiotropic effects beyond reducing portal pressure. However, studies also report potential harm in patients hospitalized with cirrhosis and ascites. We therefore investigated
Externí odkaz:
https://doaj.org/article/a61725a08399435d9515c533c3aa856b
Autor:
Alastair O'Brien
Publikováno v:
BMJ Open Gastroenterology, Vol 9, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/f790efdd83864f9fb59501b0a4af157f
Autor:
Alexander A. Maini, Natalia Becares, Louise China, Thais H. Tittanegro, Amit Patel, Roel P.H. De Maeyer, Nekisa Zakeri, Tu Vinh Long, Lucy Ly, Derek W. Gilroy, Alastair O’Brien
Publikováno v:
JHEP Reports, Vol 3, Iss 6, Pp 100332- (2021)
Background & Aims: Infection is a major problem in advanced liver disease secondary to monocyte dysfunction. Elevated prostaglandin (PG)E2 is a mediator of monocyte dysfunction in cirrhosis; thus, we examined PGE2 signalling in outpatients with ascit
Externí odkaz:
https://doaj.org/article/d3345bc59a7b459581475c760ed2675d
Autor:
Suvi Härmälä, Alastair O’Brien, Constantinos A. Parisinos, Kenan Direk, Laura Shallcross, Andrew Hayward
Publikováno v:
Diagnostic and Prognostic Research, Vol 3, Iss 1, Pp 1-11 (2019)
Abstract Background Driven by alcohol consumption and obesity, the prevalence of non-viral liver disease in the UK is increasing. Due to its silent and slow nature, the progression of liver disease is currently unpredictable and challenging to monito
Externí odkaz:
https://doaj.org/article/96286bcc0e5e4bdba4f0cecf606f0c68
Autor:
Rishen Kutmutia, Thais Tittanegro, Louise China, Ewan Forrest, Yiannis Kallis, Stephen D. Ryder, Gavin Wright, Nick Freemantle, Alastair O'Brien
Publikováno v:
American Journal of Gastroenterology. 118:105-113
Hospital-acquired infections (HAI) are common in cirrhosis with antibiotics frequently used to prevent infections, but their efficacy for this role is unknown. To investigate this, we used Albumin to Prevent Infection in Chronic Liver Failure (ATTIRE
Publikováno v:
Clinical and Translational Gastroenterology.