Zobrazeno 1 - 10
of 549
pro vyhledávání: '"Alastair M. Thompson"'
Autor:
Florentine S. Hilbers, Coralie Poncet, Konstantinos Tryfonidis, Giuseppe Viale, Suzette Delaloge, Jean-Yves Pierga, Etienne G. C. Brain, Isabel T. Rubio, Alastair M. Thompson, Emiel J. T. Rutgers, Martine J. Piccart, Laura J. van ’t Veer, Fatima Cardoso
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract Small, hormone receptor-positive (HR+), HER2-negative (HER2-), lymph node-negative breast cancers are associated with relatively low rates of disease recurrence and have therefore been underrepresented in clinical trials assessing the effect
Externí odkaz:
https://doaj.org/article/d632b4b675464734a9b0c41dc7dee912
Autor:
Kristina A. Fanucci, Yalai Bai, Vasiliki Pelekanou, Zeina A. Nahleh, Saba Shafi, Sneha Burela, William E. Barlow, Priyanka Sharma, Alastair M. Thompson, Andrew K. Godwin, David L. Rimm, Gabriel N. Hortobagyi, Yihan Liu, Leona Wang, Wei Wei, Lajos Pusztai, Kim R. M. Blenman
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract We assessed the predictive value of an image analysis-based tumor-infiltrating lymphocytes (TILs) score for pathologic complete response (pCR) and event-free survival in breast cancer (BC). About 113 pretreatment samples were analyzed from p
Externí odkaz:
https://doaj.org/article/de40aac7a42e4da9b372c3f02f74cceb
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/0c0c030dc1c54c61a794787a99cca008
Autor:
Zahi I. Mitri, Nour Abuhadra, Shaun M. Goodyear, Evthokia A. Hobbs, Andy Kaempf, Alastair M. Thompson, Stacy L. Moulder
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-5 (2022)
Abstract Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 9
Externí odkaz:
https://doaj.org/article/9f43d2c137084c2b949a03adf0c1d3b4
Autor:
Hui Chen, Qingqing Ding, Laila Khazai, Li Zhao, Senthil Damodaran, Jennifer K. Litton, Gaiane M. Rauch, Clinton Yam, Jeffrey T. Chang, Sahil Seth, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Beatriz Adrada, Kiran Virani, Jason B. White, Elizabeth Ravenberg, Xingzhi Song, Rosalind Candelaria, Banu Arun, Naoto T. Ueno, Lumarie Santiago, Sadia Saleem, Sausan Abouharb, Rashmi K. Murthy, Nuhad Ibrahim, Mark J. Routbort, Aysegul Sahin, Vicente Valero, William Fraser Symmans, Debu Tripathy, Wei-Lien Wang, Stacy Moulder, Lei Huo
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Recent advances have been made in targeting the phosphoinositide 3-kinase pathway in breast cancer. Phosphatase and tensin homolog (PTEN) is a key component of that pathway. Objective: To understand the changes in PTEN expression over the
Externí odkaz:
https://doaj.org/article/d6308ee798424003bf82ce6d0277871d
Autor:
Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of ribosome biogenesis. T
Externí odkaz:
https://doaj.org/article/fb1de5e1e47048e5883db9d402d40dd4
Autor:
Anthony J. Maxwell, Bridget Hilton, Karen Clements, David Dodwell, Joanne Dulson-Cox, Olive Kearins, Cliona Kirwan, Janet Litherland, Senthurun Mylvaganam, Elena Provenzano, Sarah E. Pinder, Elinor Sawyer, Abeer M. Shaaban, Nisha Sharma, Hilary Stobart, Matthew G. Wallis, Alastair M. Thompson
Publikováno v:
Breast, Vol 61, Iss , Pp 145-155 (2022)
Background and aim: The natural history of ductal carcinoma in situ (DCIS) is poorly understood. The aim of this cohort study was to determine the outcomes of women who had no surgery for screen-detected DCIS in the 6 months following diagnosis. Meth
Externí odkaz:
https://doaj.org/article/c3d2ce0cce0f4de89218dce7eb495851
Autor:
Pamela J. Goodwin, Ryan J. O. Dowling, Marguerite Ennis, Bingshu E. Chen, Wendy R. Parulekar, Lois E. Shepherd, Margot J. Burnell, Rachel Vander Meer, Andrea Molckovsky, Anagha Gurjal, Karen A. Gelmon, Jennifer A. Ligibel, Dawn L. Hershman, Ingrid A. Mayer, Timothy J. Whelan, Timothy J. Hobday, Priya Rastogi, Manuela Rabaglio-Poretti, Julie Lemieux, Alastair M. Thompson, Daniel W. Rea, Vuk Stambolic
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract Metformin may exert anticancer effects through indirect (mediated by metabolic changes) or direct mechanisms. The goal was to examine metformin impact on metabolic factors in non-diabetic subjects and determine whether this impact varies by
Externí odkaz:
https://doaj.org/article/ed8c22cdd63b4d8ab3a69bbf18ba9909
Autor:
Steven P. Angus, Timothy J. Stuhlmiller, Gaurav Mehta, Samantha M. Bevill, Daniel R. Goulet, J. Felix Olivares-Quintero, Michael P. East, Maki Tanioka, Jon S. Zawistowski, Darshan Singh, Noah Sciaky, Xin Chen, Xiaping He, Naim U. Rashid, Lynn Chollet-Hinton, Cheng Fan, Matthew G. Soloway, Patricia A. Spears, Stuart Jefferys, Joel S. Parker, Kristalyn K. Gallagher, Andres Forero-Torres, Ian E. Krop, Alastair M. Thompson, Rashmi Murthy, Michael L. Gatza, Charles M. Perou, H. Shelton Earp, Lisa A. Carey, Gary L. Johnson
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Inhibition of the HER2/ERBB2 receptor is a keystone to treating HER2-positive malignancies, particularly breast cancer, but a significant fraction of HER2-positive (HER2+) breast cancers recur or fail to respond. Anti-HER2 monoclonal antibod
Externí odkaz:
https://doaj.org/article/c11b8d70dbc348e48996b9c35fbb436b
Autor:
Bhavana V. Chapman, MD, Xiudong Lei, PhD, Prithvi Patil, MS, Shikha Tripathi, MS, Krista M. Nicklaus, MS, Aaron J. Grossberg, MD, PhD, Simona F. Shaitelman, MD, EdM, Alastair M. Thompson, MD, Kelly K. Hunt, MD, Thomas A. Buchholz, MD, FASTRO, Fatima Merchant, PhD, Mia K. Markey, PhD, Benjamin D. Smith, MD, FASTRO, Jay P. Reddy, MD, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 5, Iss 5, Pp 824-833 (2020)
Purpose: Our purpose was to use 3-dimensional (3D) surface photography to quantitatively measure breast cosmesis within the framework of a randomized clinical trial of conventionally fractionated (CF) and hypofractionated (HF) whole breast irradiatio
Externí odkaz:
https://doaj.org/article/0c7875f0478c4953833bd9ff46dc165e