Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alastair M. Hosie"'
Publikováno v:
Pharmacology & Therapeutics. 116:7-19
Controlling neuronal excitability is vitally important for maintaining a healthy central nervous system (CNS) and this relies on the activity of type A gamma-aminobutyric acid (GABA(A)) neurotransmitter receptors. Given this role, it is therefore imp
Publikováno v:
Journal of Biological Chemistry. 282:17855-17865
Phosphorylation can affect both the function and trafficking of GABA(A) receptors with significant consequences for neuronal excitability. Serine/threonine kinases can phosphorylate the intracellular loops between M3-4 of GABA(A) receptor beta and ga
Publikováno v:
Nature. 444:486-489
Inhibitory neurotransmission mediated by GABA(A) receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone(1). Neurosteroids are synthesized de novo in the brain during stress(2), pregnancy(3) and
Publikováno v:
The Journal of Physiology. 567:365-377
Regulation of GABAA receptors by extracellular pH exhibits a dependence on the receptor subunit composition. To date, the molecular mechanism responsible for the modulation of GABAA receptors at alkaline pH has remained elusive. We report here that t
Publikováno v:
Nature Neuroscience. 6:362-369
Zinc ions are concentrated in the central nervous system and regulate GABA(A) receptors, which are pivotal mediators of inhibitory synaptic neurotransmission. Zinc ions inhibit GABA(A) receptor function by an allosteric mechanism that is critically d
Publikováno v:
British Journal of Pharmacology. 126:1230-1236
PMBA is a novel antagonist of strychnine-sensitive glycine receptors in the rat spinal cord, however, its mode of action is unknown. The actions of PMBA on rat glycine receptor α1 and α2 homomers in Xenopus oocytes were studied under two-electrode
Autor:
Sophie E. Walker, Jeremy J. Lambert, Alastair M. Hosie, Steve D.M. Brown, Delia Belelli, Quentin M. Anstee, Irene Guerrini, Jimmy D. Bell, Edward P. Maguire, Yu-Ting Kuo, Sara Montagnese, Elizabeth M. C. Fisher, Amy H. Herlihy, Kush Ruparelia, Marsha Y. Morgan, Susanne Knapp, Philip Thomas, Trevor G. Smart, Claire I. Dixon, Howard C. Thomas, Martin Mortensen, Iain C. A. F. Robinson, Mark A. Ungless, Alonso Martínez, Rohan Bhome, Hugh Gurling, Andrew McQuillin, David N. Stephens
Publikováno v:
Nature communications
Alcohol dependence is a common, complex and debilitating disorder with genetic and environmental influences. Here we show that alcohol consumption increases following mutations to the γ-aminobutyric acidA receptor (GABAAR) β1 subunit gene (Gabrb1).
Autor:
Caleb William Holyoke, Steven D. Buckingham, Yasuhito Shirai, Howard A. Baylis, David B. Sattelle, Alastair M. Hosie
Publikováno v:
Neuroscience Letters. 189:1-4
The actions of picrotoxinin and four of its analogues were tested on a Drosophila melanogaster homo-oligomeric GABA (gamma-aminobutyric acid) receptor formed when RDL (resistance to dieldrin) subunits were expressed in Xenopus oocytes. In agreement w
Autor:
Stephen G. Brickley, Elena Kutsarova, Catriona M. Houston, Alastair M. Hosie, Georgina MacKenzie, Thomas P. McGee, Nicholas P. Franks, Efthymia Diamanti, Pablo Mateos Rodriguez, Kevin Troyano-Cuturi
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(11)
High-affinity extrasynaptic GABAAreceptors are persistently activated by the low ambient GABA levels that are known to be present in extracellular space. The resulting tonic conductance generates a form of shunting inhibition that is capable of alter
Autor:
Massimiliano Renzi, Georgina MacKenzie, Thomas P. McGee, Julian Bartram, Stephen G. Brickley, Alastair M. Hosie, Damian P. Bright, Mark Farrant
High-affinity extrasynaptic GABAAreceptors (GABAARs) are a prominent feature of cerebellar granule neurons and thalamic relay neurons. In both cell types, the presence of synaptic glomeruli would be expected to promote activation of these GABAARs, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc48a473c8b48c63167035ef72354f4
http://hdl.handle.net/11573/435489
http://hdl.handle.net/11573/435489