Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alastair L, Parkes"'
Autor:
Denes Haase, John W. Cuozzo, John Barker, Pia Thommes, Michael Zahn, Avery Hunt, Vasileios Roumpelakis, Ying Zhang, Emily Trimby, Elise Gadouleau, Alain Dorali, Kostas Papadopoulos, Ole A. Andersen, Christoph E. Dumelin, Christel Compper, Michelle Southey, Christopher Lumley, Eric A. Sigel, Paolo A. Centrella, Barbara Mertins, Maisie Holbrow-Wilshaw, Spencer Napier, Adele Faulkner, Magali Dejob, Timothy Gorman, Alastair L Parkes, Boudewijn Dejonge, Thomas Krulle, Ricky Cain, Jennifer Williams, Boer Deng, Olivier Barbeau, Anthony D. Keefe, Sian Evans, David F. Corbett, Donnya Etheridge, Daniel B. Stein, Ryan M Dominic, Dawn M. Troast, Xianfu Li, Rajesh Odedra, Matthew A. Clark, Anthony P Dickie, Holly T Soutter, Kate Spear, Angelo Sanzone
Publikováno v:
Journal of Medicinal Chemistry. 64:14377-14425
This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas ae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::561a3ec469b1a8704e6a0431f9d286c1
https://doi.org/10.1021/acs.jmedchem.1c00888
https://doi.org/10.1021/acs.jmedchem.1c00888
Autor:
Alastair L. Parkes
Publikováno v:
Expert Opinion on Drug Discovery. 15:1005-1013
The need for new antibacterial agents continues to grow, but success in development of antibiotics in recent years has been limited. To improve the chances that new compounds will progress into clinical trials and beyond, it is vital that we consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7deeb2e0a9bdf2634dc922cbea1b5e4
https://doi.org/10.1080/17460441.2020.1767065
https://doi.org/10.1080/17460441.2020.1767065
Autor:
M Dominic, Ryan, Alastair L, Parkes, David, Corbett, Anthony P, Dickie, Michelle, Southey, Ole A, Andersen, Daniel B, Stein, Olivier R, Barbeau, Angelo, Sanzone, Pia, Thommes, John, Barker, Ricky, Cain, Christel, Compper, Magali, Dejob, Alain, Dorali, Donnya, Etheridge, Sian, Evans, Adele, Faulkner, Elise, Gadouleau, Timothy, Gorman, Denes, Haase, Maisie, Holbrow-Wilshaw, Thomas, Krulle, Xianfu, Li, Christopher, Lumley, Barbara, Mertins, Spencer, Napier, Rajesh, Odedra, Kostas, Papadopoulos, Vasileios, Roumpelakis, Kate, Spear, Emily, Trimby, Jennifer, Williams, Michael, Zahn, Anthony D, Keefe, Ying, Zhang, Holly T, Soutter, Paolo A, Centrella, Matthew A, Clark, John W, Cuozzo, Christoph E, Dumelin, Boer, Deng, Avery, Hunt, Eric A, Sigel, Dawn M, Troast, Boudewijn L M, DeJonge
Publikováno v:
Journal of medicinal chemistry. 64(19)
This study describes a novel series of UDP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1d1f373433e8f065b03c7c212d95e83
https://pubmed.ncbi.nlm.nih.gov/34569791
https://pubmed.ncbi.nlm.nih.gov/34569791
Autor:
Alastair L. Parkes, Ian A Yule
Publikováno v:
Expert opinion on drug discovery. 11(7)
There is a growing need for new antibacterial agents, but success in development of antibiotics in recent years has been limited. This has led researchers to investigate novel approaches to finding compounds that are effective against multi-drug resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8a5d16f74fef371a4e06feb8d3325d
https://pubmed.ncbi.nlm.nih.gov/27169483
https://pubmed.ncbi.nlm.nih.gov/27169483
Publikováno v:
Angewandte Chemie International Edition. 44:6731-6734
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b23bb2e414dfc0a6b287a9384c3699
https://doi.org/10.1002/anie.200501591
https://doi.org/10.1002/anie.200501591
Autor:
James M. Smith, John D. Sutherland, Fabien F. Buchet, Alastair L. Parkes, Carole Anastasi, Michael A. Crowe, Matthew W. Powner
Publikováno v:
ChemInform. 38
Spectacular advances in structural and molecular biology have added support to the 'RNA world' hypothesis, and provide a mandate for chemistry to explain how RNA might have been generated prebiotically on the early earth. Difficulties in achieving a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d75d21016f42b42698459169e05895
https://doi.org/10.1002/chin.200726271
https://doi.org/10.1002/chin.200726271
Autor:
Matthew W. Powner, Jim Raftery, John D. Sutherland, Michael A. Crowe, Carole Anastasi, Alastair L. Parkes
Publikováno v:
Chembiochem : a European journal of chemical biology. 8(10)
Recent work has emphasised the importance of D-ribose aminooxazoline 1 in the synthesis of cytidine ribonucleosides under potentially prebiotic conditions. Upon treatment with cyanoacetylene, 1 is transformed into alpha-D-cytidine (alpha-2), and if a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999cd1e6f5babc17c11d47e51a8a9974
https://pubmed.ncbi.nlm.nih.gov/17549787
https://pubmed.ncbi.nlm.nih.gov/17549787
Autor:
Stephen G. Davies, Juan A. Tamayo, Andrew D. Smith, A. Christopher Garner, Alastair L. Parkes, Paul M. Roberts, Steven D. Bull, James E. Thomson, Thomas G. R. Sellers, Richard Vickers
Publikováno v:
New Journal of Chemistry. 31:486
High levels of diastereoselectivity are observed for benzylation of the lithium enolates of (S)-N,N′-bis-para-methoxybenzyl-3-iso-propyl- piperazine-2,5-dione, (S)-N(1)-para-methoxybenzyl-N(4)-methyl-3-iso-propyl- piperazine-2,5-dione and (S)-N(1)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1156861187f6e111fb789f2226e8c6
https://doi.org/10.1039/b701628j
https://doi.org/10.1039/b701628j
Autor:
Steven D. Bull, Stephen G. Davies, A. Christopher Garner, Alastair L. Parkes, Paul M. Roberts, Thomas G. R. Sellers, Andrew D. Smith, Juan A. Tamayo, James E. Thomson, Richard J. Vickers
Publikováno v:
New Journal of Chemistry; Apr2007, Vol. 31 Issue 4, p486-495, 10p
Publikováno v:
Angewandte Chemie International Edition; Oct2005, Vol. 44 Issue 41, p6731-6734, 0p