Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alastair Kerr"'
Autor:
Alicia-Marie Conway, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Francesca Chemi, Dan Slane-Tan, Saba Ferdous, A. S. Md Mukarram Hossain, Katarzyna Kamieniecka, Daniel J. White, Claire Mitchell, Alastair Kerr, Matthew G. Krebs, Gerard Brady, Caroline Dive, Natalie Cook, Dominic G. Rothwell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Cancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy. Predicting tissue-of-origin (TOO) molecularly could help refine this diagnosis, with
Externí odkaz:
https://doaj.org/article/d4bcd616a1c54d2c97e8ef0bccad3ec9
Autor:
Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (C
Externí odkaz:
https://doaj.org/article/a99beedee95f4504bd782063edbc7711
A model of k-mer surprisal to quantify local sequence information content surrounding splice regions
Publikováno v:
PeerJ, Vol 8, p e10063 (2020)
Molecular sequences carry information. Analysis of sequence conservation between homologous loci is a proven approach with which to explore the information content of molecular sequences. This is often done using multiple sequence alignments to suppo
Externí odkaz:
https://doaj.org/article/c6f890ee67d44d59b6a444a2f4c4411e
Publikováno v:
EBioMedicine, Vol 30, Iss , Pp 248-260 (2018)
Long non-coding RNAs (lncRNAs) belong to a recently discovered class of molecules proposed to regulate various cellular processes. Here, we systematically analyzed their expression in human subcutaneous white adipose tissue (WAT) and found that a lim
Externí odkaz:
https://doaj.org/article/04889f6db03c49f99e4ff32066e854ef
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193332 (2018)
The design of highly diverse phage display libraries is based on assumption that DNA bases are incorporated at similar rates within the randomized sequence. As library complexity increases and expected copy numbers of unique sequences decrease, the e
Externí odkaz:
https://doaj.org/article/0d8e23758ae34a45ac93443e39805a58
Autor:
Renad Zhdanov, Eric Schirmer, Anuroop Venkateswaran Venkatasubramani, Alastair Kerr, Elena Mandrou, Giovanny Rodriguez Blanco, Alexander Kagansky
Publikováno v:
ScienceOpen Research (2016)
Abstract Isolated cases of experimental evidence over the last few decades have shown that, where specifically tested, both prokaryotes and eukaryotes have specific lipid species bound to nucleoproteins of the genome. In vitro, some of these lipid sp
Externí odkaz:
https://doaj.org/article/eaf2f6d2abd24d46971e1441126d787c
Autor:
Renad Zhdanov, Eric Schirmer, Anuroop Venkateswaran Venkatasubramani, Alastair Kerr, Elena Mandrou, Giovanny Rodriguez Blanco, Alexander Kagansky
Publikováno v:
ScienceOpen Research (2015)
Abstract Isolated cases of experimental evidence over the last few decades have shown that, where specifically tested, both prokaryotes and eukaryotes have specific lipid molecules bound to nucleoproteins of the genome. In vitro, some of these lipids
Externí odkaz:
https://doaj.org/article/ffd8b0166d714bdfbbfe31de15d67921
Publikováno v:
eLife, Vol 4 (2015)
The cohesin ring holds newly replicated sister chromatids together until their separation at anaphase. Initiation of sister chromatid cohesion depends on a separate complex, Scc2NIPBL/Scc4Mau2 (Scc2/4), which loads cohesin onto DNA and determines its
Externí odkaz:
https://doaj.org/article/72dfe75d29c843abb8dd87f6853cdf47
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004716 (2014)
During transcription, the nascent RNA can invade the DNA template, forming extended RNA-DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase H to map targets of RNase H activity throughout the budding yeast genome. I
Externí odkaz:
https://doaj.org/article/7e8b045862bf44479bebd7e082246bab
Autor:
Kitty F Verzijlbergen, Olga O Nerusheva, David Kelly, Alastair Kerr, Dean Clift, Flavia de Lima Alves, Juri Rappsilber, Adele L Marston
Publikováno v:
eLife, Vol 3 (2014)
To protect against aneuploidy, chromosomes must attach to microtubules from opposite poles (‘biorientation’) prior to their segregation during mitosis. Biorientation relies on the correction of erroneous attachments by the aurora B kinase, which
Externí odkaz:
https://doaj.org/article/598ffcbbe7824df7bfdae8cdcff55377