Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alastair J. Hayes"'
Autor:
Alastair J. Hayes, Xiaozhong Zheng, James O’Kelly, Lucile P.A. Neyton, Natalia A. Bochkina, Iain Uings, John Liddle, J. Kenneth Baillie, George Just, Margaret Binnie, Natalie Z.M. Homer, Toby B.J. Murray, James Baily, Kris McGuire, Christos Skouras, O. James Garden, Scott P. Webster, John P. Iredale, Sarah E.M. Howie, Damian J. Mole
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112763- (2023)
Summary: Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now. Here, we show that the KMO product 3-hydrox
Externí odkaz:
https://doaj.org/article/60fcd40d031a4ce4a162a97e4de568a3
Autor:
Alastair J. Hayes, Damian J. Mole
Publikováno v:
Surgery (Oxford). 35:700-706
Autor:
Stuart Robinson, Roberto Valente, Darko Siuka, Gabriele Capurso, Daniel Kämmerer, Alastair J. Hayes, Emilie Korsæth, Björn Lindkvist, Gianfranco Delle Fave, Patrick Maisonneuve, Per Hedenström, Sven-Petter Haugvik
Publikováno v:
Valente, R, Hayes, A J, Haugvik, S-P, Hedenström, P, Siuka, D, Korsæth, E, Kaemmerer, D, Robinson, S M, Maisonneuve, P, Delle Fave, G, Lindkvist, B & Capurso, G 2017, ' Risk and Protective Factors for the Occurrence of Sporadic Pancreatic Endocrine Neoplasms ', Endocrine-Related Cancer . https://doi.org/10.1530/ERC-17-0040
Pancreatic neuroendocrine neoplasms (PNENs) represent 10% of all pancreatic tumors by prevalence. Their incidence has reportedly increased over recent decades in parallel with that of pancreatic adenocarcinoma. PNENs are relatively rare, and of the f
Publikováno v:
HPB. 23:S218
Publikováno v:
Hayes, A J, Skouras, C, Haugk, B & Charnley, R M 2015, ' Keap1-Nrf2 signalling in pancreatic cancer ', International Journal of Biochemistry and Cell Biology, vol. 65, pp. 288-299 . https://doi.org/10.1016/j.biocel.2015.06.017
Transcription factor NF-E2 p45-related factor 2 (Nrf2, also called Nfe2l2), a master regulator of redox homeostasis, and its dominant negative regulator, Kelch-like ECH-associated protein 1 (Keap1), together tightly control the expression of numerous
Autor:
Alastair J. Hayes, Linda Williams, Christos Skouras, Rowan W. Parks, O. James Garden, Damian J. Mole
Publikováno v:
HPB. 16:789-796
BackgroundThe effect of early organ dysfunction on long-term survival in acute pancreatitis (AP) patients is unknown.ObjectiveThe aim of this study was to ascertain whether early organ dysfunction impacts on long-term survival after an episode of AP.
Autor:
Alastair J. Hayes, Damian J. Mole
Publikováno v:
Hayes, A & Mole, D 2016, ' Mitogen-Activated Protein Kinase/Extracellular Signal–Regulated Kinase Inhibition During Sepsis Dampens the Early Systemic Inflammatory Response ', Critical Care Medicine, vol. 44, no. 8 . https://doi.org/10.1097/CCM.0000000000001752
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296fa5fde82f17afcf837e2455e73b51
https://hdl.handle.net/20.500.11820/be61468d-0592-4adc-8a82-774eb3565e92
https://hdl.handle.net/20.500.11820/be61468d-0592-4adc-8a82-774eb3565e92
Autor:
Finny Paterson, Iain Uings, John P. Iredale, Lisa Derr, George E. Dukes, Dawn Lyster, Andreas Tsoumanis, Lesley Briody, Natalie Z.M. Homer, Darren C. Robertson, Xiaozhong Zheng, Damian J. Mole, Alastair J. Hayes, Christos Skouras, Wayne L. Wright, O. James Garden, Toby B J Murray, Rowan W. Parks, Scott P. Webster, Heather Spence, John Liddle, Margaret Binnie
Publikováno v:
Scientific Reports
Skouras, C, Zheng, X, Binnie, M, Homer, N Z M, Murray, T B J, Robertson, D, Briody, L, Paterson, F, Spence, H, Derr, L, Hayes, A J, Tsoumanis, A, Lyster, D, Parks, R W, Garden, O J, Iredale, J P, Uings, I J, Liddle, J, Wright, W L, Dukes, G, Webster, S P & Mole, D J 2016, ' Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis ', Scientific Reports, vol. 6, pp. 33951 . https://doi.org/10.1038/srep33951
Skouras, C, Zheng, X, Binnie, M, Homer, N Z M, Murray, T B J, Robertson, D, Briody, L, Paterson, F, Spence, H, Derr, L, Hayes, A J, Tsoumanis, A, Lyster, D, Parks, R W, Garden, O J, Iredale, J P, Uings, I J, Liddle, J, Wright, W L, Dukes, G, Webster, S P & Mole, D J 2016, ' Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis ', Scientific Reports, vol. 6, pp. 33951 . https://doi.org/10.1038/srep33951
Inhibition of kynurenine 3-monooxygenase (KMO) protects against multiple organ dysfunction (MODS) in experimental acute pancreatitis (AP). We aimed to precisely define the kynurenine pathway activation in relation to AP and AP-MODS in humans, by carr
Publikováno v:
Journal of Endometriosis. 3:120-123
Purpose To explain an unusually severe presentation of concurrent sigmoid diverticulosis and endometriosis. Intestinal endometriosis can be complicated by colonic obstruction, perforation, fistula formation, and sepsis. Suppurative thrombosis of the
Autor:
Darko Siuka, Alastair J. Hayes, Björn Lindkvist, Emilie Korsæth, Roberto Valente, Gabriele Capurso, Per Hedenström, Patrick Maisonneuve, Ivar P. Gladhaug, Sven-Petter Haugvik
Publikováno v:
Neuroendocrinology. 101(2)
Background and Aims: Risk factors for pancreatic neuroendocrine tumors (PNETs) are not well understood. The aim of this systematic review was to assess if diabetes mellitus, smoking, alcohol use, and family history of cancer are risk factors for PNET