Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alastair J. H. Brown"'
Autor:
Thomas L. Williams, Robyn G. C. Macrae, Rhoda E. Kuc, Alastair J. H. Brown, Janet J. Maguire, Anthony P. Davenport
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe apelin receptor binds two distinct endogenous peptides, apelin and ELA, which act in an autocrine/paracrine manner to regulate the human cardiovascular system. As a class A GPCR, targeting the apelin receptor is an attractive therapeu
Externí odkaz:
https://doaj.org/article/bf7d26bd0e894f9489e39b0a341afeaa
Autor:
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Externí odkaz:
https://doaj.org/article/6bc41c8173af451ba843ce9103cfc57b
Autor:
Matilda Shackley, Yue Ma, Edward W. Tate, Alastair J. H. Brown, Gary Frost, Aylin C. Hanyaloglu
Publikováno v:
Frontiers in Nutrition, Vol 7 (2020)
The short chain fatty acids (SCFAs) acetate, butyrate and propionate, are produced by fermentation of non-digestible carbohydrates by the gut microbiota and regulate appetite, adiposity, metabolism, glycemic control, and immunity. SCFAs act at two di
Externí odkaz:
https://doaj.org/article/31540f5f1b5e4233a5314fe94deefec9
Autor:
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/e8d149c342564fbcb1a1d42b3d13ea6d
Autor:
Andrew B. Tobin, Gerard R. Dawson, Patrick M. Sexton, Nathan Robertson, Sophie J. Bradley, Francesca Perini, Arthur Christopoulos, James C. Errey, Barry John Teobald, John Francis William Deakin, Lisa M. Broad, Jan Liptrot, Christopher J. Langmead, K.A. Bennett, Mary Vinson, Pradeep J. Nathan, Colin Molloy, Robert M. Cooke, Edward Hurrell, Michael Browning, Krzysztof Okrasa, Jason M Brown, Giulio Mattedi, Alastair J. H. Brown, David M. Cross, Greg J. Osborne, Julie E. Cansfield, Ali Jazayeri, Christoffer Bundgaard, Stephen R. Morairty, J.C. Patel, Fiona H. Marshall, Brian D. Hudson, Prakash Rucktooa, Robert T. Smith, Keith G. Phillips, Louis Dwomoh, Chris de Graaf, Malcolm Peter Weir, Julie Warneck, Giles A. Brown, Mark Pickworth, Benjamin G. Tehan, Tim Tasker, Anushka V. Goonawardena, Miles Congreve, João M. Dias, Shahram Shahabi
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b008b7a3c01abe25b8e63fdab465cc4
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
Autor:
Anthony P. Davenport, Chris de Graaf, Alastair J. H. Brown, Janet J. Maguire, Conor C. G. Scully
Publikováno v:
Nature Reviews Drug Discovery. 19:389-413
Dysregulation of peptide-activated pathways causes a range of diseases, fostering the discovery and clinical development of peptide drugs. Many endogenous peptides activate G protein-coupled receptors (GPCRs) — nearly 50 GPCR peptide drugs have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b64cfcaed9e530ff0c01db3aa64259
https://doi.org/10.1038/s41573-020-0062-z
https://doi.org/10.1038/s41573-020-0062-z
Autor:
John-Paul Taylor, Geor Bakker, Daniel Erskine, Alastair J. H. Brown, Pradeep J. Nathan, Tim Tasker
Publikováno v:
Drug Discovery Today. 24:2307-2314
Cholinergic dysfunction is involved in a range of neurological and psychiatric disorders, including schizophrenia, dementia and Lewy body disease (LBD), leading to widespread use of cholinergic therapies. However, such drugs have focused on increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::249956fdc9616f5a834e0ab83fe7bf74
https://doi.org/10.1016/j.drudis.2019.08.009
https://doi.org/10.1016/j.drudis.2019.08.009
Autor:
Jack R. Mellor, Benjamin G. Tehan, Miles Congreve, Alastair J. H. Brown, Pradeep J. Nathan, Matt Udakis, Giles Albert Brown, Jon Palacios-Filardo
Publikováno v:
Palacios-Filardo, J, Udakis, M, Mellor, J R & al., E 2021, ' Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits ', Nature Communications, vol. 12, no. 1, 5475 . https://doi.org/10.1038/s41467-021-25280-5
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Funder: Biotechnology and Biological Sciences Research Council
Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formatio
Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bafd7502f86d226d45b37546b720de6
https://www.repository.cam.ac.uk/handle/1810/331856
https://www.repository.cam.ac.uk/handle/1810/331856
Autor:
Fiona M. Gribble, Richard G. Kay, Janet J. Maguire, Rhoda E. Kuc, Duuamene Nyimanu, Alastair J. H. Brown, Anthony P. Davenport
Publikováno v:
Peptides
Highlights • Elabela/Toddler (ELA) is the second endogenous ligand of the apelin receptor identified in zebrafish. • Mature ELA was predicted to be cleaved into [Pyr1]ELA-32, ELA-21 and ELA-11, based on the presence of dibasic amino acid residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b84ae36bdd52ea9b3f11147b6d8feb7
Autor:
Pradeep J, Nathan, S Babli, Millais, Alex, Godwood, Odile, Dewit, David M, Cross, Janet, Liptrot, Bharat, Ruparelia, Stephen Paul, Jones, Geor, Bakker, Paul T, Maruff, Gregory A, Light, Alastair J H, Brown, Malcolm Peter, Weir, Miles, Congreve, Tim, Tasker
Publikováno v:
Alzheimer'sdementia (New York, N. Y.). 8(1)
This study examined the safety and pharmacodynamic effects of selective muscarinic MA randomized, double-blind, placebo-controlled 4-week safety study of HTL0018318 with up-titration and maintenance phases, observing exploratory effects on electrophy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad0c05b300f87c734f6afd7887305f6d
https://pubmed.ncbi.nlm.nih.gov/35229025
https://pubmed.ncbi.nlm.nih.gov/35229025