Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alastair J M Watson"'
Autor:
Oliver J Maclaren, Aimée Parker, Carmen Pin, Simon R Carding, Alastair J M Watson, Alexander G Fletcher, Helen M Byrne, Philip K Maini
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005688 (2017)
Our work addresses two key challenges, one biological and one methodological. First, we aim to understand how proliferation and cell migration rates in the intestinal epithelium are related under healthy, damaged (Ara-C treated) and recovering condit
Externí odkaz:
https://doaj.org/article/c51090bb4d624b438d20bf4f061ad52c
Autor:
Bryony N Parsons, Paul Wigley, Hannah L Simpson, Jonathan M Williams, Suzie Humphrey, Anne-Marie Salisbury, Alastair J M Watson, Stephen C Fry, David O'Brien, Carol L Roberts, Niamh O'Kennedy, Asa V Keita, Johan D Söderholm, Jonathan M Rhodes, Barry J Campbell
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87658 (2014)
Soluble fibres (non-starch polysaccharides, NSP) from edible plants but particularly plantain banana (Musa spp.), have been shown in vitro and ex vivo to prevent various enteric pathogens from adhering to, or translocating across, the human intestina
Externí odkaz:
https://doaj.org/article/c9650eb50de44dbd8d9db0a1f8f63863
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37115 (2012)
We developed a slow structural relaxation model to describe cellular dynamics in the crypt of the mouse small intestine. Cells are arranged in a three dimensional spiral the size of which dynamically changes according to cell production demands of ad
Externí odkaz:
https://doaj.org/article/956fda881b0840de8ee238e199c62d8d
Autor:
Luz del Carmen Martínez-Sánchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Marketa Kubankova, Christine Schweitzer, Tatyana Koch, Veronika Thonn, Lena Erkert, Iris Stolzer, Claudia Günther, Christoph Becker, Benno Weigmann, Monika Klewer, Christoph Daniel, Kerstin Amann, Stefan Tenzer, Raja Atreya, Martin Bergo, Cord Brakebusch, Alastair J M Watson, Jochen Guck, Ben Fabry, Imke Atreya, Markus F Neurath, Rocío López-Posadas
Publikováno v:
Martínez-Sánchez, L D C, Ngo, P A, Pradhan, R, Becker, L-S, Boehringer, D, Soteriou, D, Kubankova, M, Schweitzer, C, Koch, T, Thonn, V, Erkert, L, Stolzer, I, Günther, C, Becker, C, Weigmann, B, Klewer, M, Daniel, C, Amann, K, Tenzer, S, Atreya, R, Bergo, M, Brakebusch, C, Watson, A J M, Guck, J, Fabry, B, Atreya, I, Neurath, M F & López-Posadas, R 2023, ' Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation ', Gut, vol. 72, no. 2, pp. 275-294 . https://doi.org/10.1136/gutjnl-2021-325520
Gut
Gut
ObjectiveIncreased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16fe74d36fb6f2e53d3dc23124ec32a
https://ueaeprints.uea.ac.uk/id/eprint/83973/
https://ueaeprints.uea.ac.uk/id/eprint/83973/
Autor:
Sally Haw, Gillian Sweetman, Sarkis Manoukian, Lisa Kidd, Stephen J. Leslie, Ronan E. O'Carroll, Alastair J M Watson, Nanette Mutrie, Richard Adams, Shaun Treweek, Anna Campbell, Gill Hubbard, Julie Munro, P Rauchaus, Helen Mason
Publikováno v:
Health Services and Delivery Research, Vol 4, Iss 24 (2016)
BackgroundColorectal cancer (CRC) survivors are not meeting the recommended physical activity levels associated with improving their chances of survival and quality of life. Rehabilitation could address this problem.ObjectivesThe aims of the Cardiac
Autor:
Oliver J, Maclaren, Aimée, Parker, Carmen, Pin, Simon R, Carding, Alastair J M, Watson, Alexander G, Fletcher, Helen M, Byrne, Philip K, Maini
Publikováno v:
PLoS Computational Biology
Our work addresses two key challenges, one biological and one methodological. First, we aim to understand how proliferation and cell migration rates in the intestinal epithelium are related under healthy, damaged (Ara-C treated) and recovering condit
Publikováno v:
Journal of Pediatric Gastroenterology and Nutrition. 31:356-361
Autor:
Alastair J M, Watson, Kevin R, Hughes
Publikováno v:
Annals of the New York Academy of Sciences. 1258
Although epithelial cells are continuously shed from the surface of the intestine, the intestinal epithelium maintains the integrity of the epithelial barrier. This is achieved through a highly dynamic process involving reorganization of tight juncti
Publikováno v:
BMJ (Clinical research ed.). 316(7124)
The local research ethics committee is the most independent body regulating the ethical conduct of research.1 The committee works on behalf of the subjects of research, to protect them from unacceptable risks and practices. However, the effectiveness
Autor:
Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina Divekar, Jasmine Buck, Tomasz Wrzesinski, Matthew Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J. M. Watson, Simon R. Carding, Wilfried Haerty, Federica Di Palma, Ulrike Mayer, Penny P. Powell, Isabelle Hautefort, Tom Wileman, Tamas Korcsmaros
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 3 (2019)
Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and are often associated with digestive
Externí odkaz:
https://doaj.org/article/a6552716ae754941bec316fd4f082a50