Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Alastair Droop"'
Autor:
Georgette Tanner, Rhiannon Barrow, Shoaib Ajaib, Muna Al-Jabri, Nazia Ahmed, Steven Pollock, Martina Finetti, Nora Rippaus, Alexander F. Bruns, Khaja Syed, James A. Poulter, Laura Matthews, Thomas Hughes, Erica Wilson, Colin Johnson, Frederick S. Varn, Anke Brüning-Richardson, Catherine Hogg, Alastair Droop, Arief Gusnanto, Matthew A. Care, Luisa Cutillo, David R. Westhead, Susan C. Short, Michael D. Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Roel G. W. Verhaak, Lucy F. Stead
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)
Abstract Background Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur. Results Using RNA sequencing da
Externí odkaz:
https://doaj.org/article/190c474079fc465a883fccd59c89b7b7
Autor:
Ashley Sunderland, Jennifer Williams, Tereza Andreou, Nora Rippaus, Christopher Fife, Fiona James, Yolanda Dyah Kartika, Valerie Speirs, Ian Carr, Alastair Droop, Mihaela Lorger
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches. We used an in vivo model of triple negative brea
Externí odkaz:
https://doaj.org/article/edd0e15041a74a878fd5719f0821bcfc
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Subclonal deconvolution in cancer sequencing data is a complex task, and the optimal tools to use are unclear. Here, the authors systematically benchmark subclonal deconvolution pipelines with a comprehensive set of simulated tumour genomes and ident
Externí odkaz:
https://doaj.org/article/f5475b13ac43401197d2270caf88aa9a
Autor:
Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella, Patrick Thomas, Guy Sauvageau, David J. Adams, Chi C. Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Cut-like homeobox 1 (CUX1) is a haploinsufficient tumor suppressor commonly inactivated in acute myeloid leukemia and high-risk myelodysplasia. Here, in a genetically modified murine model, the authors show that CUX1 deficiency impairs apoptosis lead
Externí odkaz:
https://doaj.org/article/dda81ff46bb244da8bbf4aca6a147a93
Autor:
Louise van der Weyden, Victoria Harle, Gemma Turner, Victoria Offord, Vivek Iyer, Alastair Droop, Agnieszka Swiatkowska, Roy Rabbie, Andrew D. Campbell, Owen J. Sansom, Mercedes Pardo, Jyoti S. Choudhary, Ingrid Ferreira, Mark Tullett, Mark J. Arends, Anneliese O. Speak, David J. Adams
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Louise van der Weyden et al. report a CRISPRa screen in mice to identify membrane protein-encoding genes that, when overexpressed, enhance the metastatic potential of melanoma cells. They find that high expression of LRRN4CL in melanoma cells increas
Externí odkaz:
https://doaj.org/article/4f4c4eec5cbe46db9a452ba009fd123d
Autor:
Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, David J. Adams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Systematic screens for synthetic lethal gene pairs represent a powerful approach to define interactions that may be exploited in the clinic. Here, the authors use a dual-guide CRISPR screening approach to screen a curated selection of gene pairs acro
Externí odkaz:
https://doaj.org/article/15ae5ef51cdf48aab01435241bfc2c36
Autor:
Adriana Buskin, Lili Zhu, Valeria Chichagova, Basudha Basu, Sina Mozaffari-Jovin, David Dolan, Alastair Droop, Joseph Collin, Revital Bronstein, Sudeep Mehrotra, Michael Farkas, Gerrit Hilgen, Kathryn White, Kuan-Ting Pan, Achim Treumann, Dean Hallam, Katarzyna Bialas, Git Chung, Carla Mellough, Yuchun Ding, Natalio Krasnogor, Stefan Przyborski, Simon Zwolinski, Jumana Al-Aama, Sameer Alharthi, Yaobo Xu, Gabrielle Wheway, Katarzyna Szymanska, Martin McKibbin, Chris F. Inglehearn, David J. Elliott, Susan Lindsay, Robin R. Ali, David H. Steel, Lyle Armstrong, Evelyne Sernagor, Henning Urlaub, Eric Pierce, Reinhard Lührmann, Sushma-Nagaraja Grellscheid, Colin A. Johnson, Majlinda Lako
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Mutations in pre-mRNA processing factors cause autosomal dominant retinitis pigmentosa. Here the authors provide insights into the pathophysiological mechanisms underlying non-syndromic retinal disease caused by heterozygous mutations in genes encodi
Externí odkaz:
https://doaj.org/article/39722a7de98941cab07e48fc0b8400de
Autor:
Valerie Speirs, Abeer M. Shaaban, Lucy F. Stead, Davide Melisi, Marie-Louise Fjällskog, Ingrid A. Hedenfalk, Maria G. Daidone, Vera Cappelletti, Helene H. Thygesen, Margaret Jeffery, Ian O. Ellis, Janina Kulka, Rosemary A. Walker, Mark Stephens, Sami Shousha, Elena Provenzano, Marcella Mottolese, Anna Di Benedetto, Maria Litwiniuk, Rani Kanthan, J. Louise Jones, Lee B. Jordan, Laura Fulford, Jo Dent, Gabor Cserni, Hedieh Honarpisheh, Cecilia Nilsson, Carmine Carbone, Charlotte A.B. Suleman, Alastair Droop, Sreekumar Sundara Rajan, Matthew P. Humphries
Interrogation of Oncomine{trade mark, serif} (https://www.oncomine.org/) showed higher expression of eIF4E and eIF5 in breast (top panel) and lung cancer (bottom panel) compared to normal tissue. When these biomarkers were compared for gender, eIF4E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cde27b41ba08b5a7ceab6f3d713b07e
https://doi.org/10.1158/1078-0432.22466838
https://doi.org/10.1158/1078-0432.22466838
Autor:
Valerie Speirs, Abeer M. Shaaban, Lucy F. Stead, Davide Melisi, Marie-Louise Fjällskog, Ingrid A. Hedenfalk, Maria G. Daidone, Vera Cappelletti, Helene H. Thygesen, Margaret Jeffery, Ian O. Ellis, Janina Kulka, Rosemary A. Walker, Mark Stephens, Sami Shousha, Elena Provenzano, Marcella Mottolese, Anna Di Benedetto, Maria Litwiniuk, Rani Kanthan, J. Louise Jones, Lee B. Jordan, Laura Fulford, Jo Dent, Gabor Cserni, Hedieh Honarpisheh, Cecilia Nilsson, Carmine Carbone, Charlotte A.B. Suleman, Alastair Droop, Sreekumar Sundara Rajan, Matthew P. Humphries
Purpose: Breast cancer affects both genders, but is understudied in men. Although still rare, male breast cancer (MBC) is being diagnosed more frequently. Treatments are wholly informed by clinical studies conducted in women, based on assumptions tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174b3ffbad5c34c993f0cf995b181a98
https://doi.org/10.1158/1078-0432.c.6526449.v1
https://doi.org/10.1158/1078-0432.c.6526449.v1