Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Alastair D Robertson"'
Autor:
Christopher M O'Connor, Mona Fiuzat, Peter E Carson, Inder S Anand, Jonathan F Plehn, Stephen S Gottlieb, Marc A Silver, JoAnn Lindenfeld, Alan B Miller, Michel White, Ryan Walsh, Penny Nelson, Allen Medway, Gordon Davis, Alastair D Robertson, J David Port, James Carr, Guinevere A Murphy, Laura C Lazzeroni, William T Abraham, Stephen B Liggett, Michael R Bristow
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e44324 (2012)
Pharmacogenetics involves complex interactions of gene products affecting pharmacodynamics and pharmacokinetics, but there is little information on the interaction of multiple genetic modifiers of drug response. Bucindolol is a β-blocker/sympatholyt
Externí odkaz:
https://doaj.org/article/cd47e15ce88a411b9af992526484b8c4
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48184 (2012)
Heart failure patients with reduced ejection fraction (HFREF) are heterogenous, and our ability to identify patients likely to respond to therapy is limited. We present a method of identifying disease subtypes using high-dimensional clinical phenotyp
Externí odkaz:
https://doaj.org/article/6169e42a4ba04e569672bf5c6fdba341
Autor:
Stephen B. Liggett, William H. Sauer, Alastair D. Robertson, Michael R. Bristow, Ryan G. Aleong
Publikováno v:
Circulation: Arrhythmia and Electrophysiology. 6:137-143
Background— β-blockers prevent cardiac arrhythmias in patients with chronic heart failure and reduced left ventricular ejection fraction, including ventricular tachycardia/ventricular fibrillation (VT/VF). We hypothesized that prevention of ventri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b702f048a608510127fa0d708b2e2f5
https://doi.org/10.1161/circep.111.969618
https://doi.org/10.1161/circep.111.969618
Autor:
Wayne Minobe, Lawrence Hunter, Michael R. Bristow, Ronald Zolty, Alastair D. Robertson, Brian D. Lowes, Sonia M. Leach
Publikováno v:
The Journal of Heart and Lung Transplantation. 25:579-588
Background In chronic heart failure due to a dilated cardiomyopathy phenotype, the molecular bases for contractile dysfunction and chamber remodeling remain largely unidentified. Methods To investigate the feasibility of measuring global gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3407ca244a4441add43006eebfdb75
https://doi.org/10.1016/j.healun.2006.01.006
https://doi.org/10.1016/j.healun.2006.01.006
Autor:
Eugene E. Wolfel, Ronald Zolty, Marc A. Simon, Simon F. Shakar, Brian D. Lowes, Alastair D. Robertson, Michael R. Bristow, JoAnn Lindenfeld
Publikováno v:
Journal of Cardiac Failure. 10:15-20
Background Peak oxygen consumption (VO 2 ) is an important criterion for listing patients for cardiac transplantation. β-Blockers improve survival without affecting peak VO 2 . We questioned the value of peak VO 2 in predicting outcome in patients t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739a990ca983c9db2e73377790f1a5fd
https://doi.org/10.1016/s1071-9164(03)00593-1
https://doi.org/10.1016/s1071-9164(03)00593-1
Dose-Related Effects of Methadone on QT Prolongation in a Series of Patients with Torsade de Pointes
Publikováno v:
Pharmacotherapy. 23:802-805
Study Objective. To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone-treated patients who developed torsade de pointes. Design. Retrospective case serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea411b51e116d73f6b3ae7a27311443
https://doi.org/10.1592/phco.23.6.802.32186
https://doi.org/10.1592/phco.23.6.802.32186
Autor:
Shuping Ge, Wayne Minobe, Steve M. Helmke, Michael R. Bristow, M. Benjamin Perryman, Alastair D. Robertson, Gary Brodsky, Teresa J. Bohlmeyer, Jennifer Lynch, James H Sederberg
Publikováno v:
Cardiovascular Pathology. 12:23-31
Introduction: Hypoplastic left heart syndrome (HLHS) is the term used to describe a group of congenital malformations characterized by marked underdevelopment of the left side of the heart. HLHS accounts for nearly 25% of cardiac deaths in the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d91467b9f5fb45840b79e3167f2448a
https://doi.org/10.1016/s1054-8807(02)00127-8
https://doi.org/10.1016/s1054-8807(02)00127-8
Autor:
J. A. Lindenfeld, Robert L. Roden, Eugene E. Wolfel, Simon F. Shakar, Patti Larrabee, Edward M. Gilbert, Wayne Minobe, Debra A. Ferguson, Jennifer V. Linseman, Kirk Volkman, Brian D. Lowes, Darrin L. Dutcher, Michael R. Bristow, Alastair D. Robertson, James H Sederberg, Robert A. Quaife, William T. Abraham
Publikováno v:
Molecular Medicine. 8:750-760
BACKGROUND: The most common cause of chronic heart failure in the US is secondary or primary dilated cardiomyopathy (DCM). The DCM phenotype exhibits changes in the expression of genes that regulate contractile function and pathologic hypertrophy. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb1703eecdcd99429032ae94261e30aa
https://doi.org/10.1007/bf03402039
https://doi.org/10.1007/bf03402039
Autor:
Antonio D'Aloia, Alastair D. Robertson, Marco Metra, Michael R. Bristow, Savina Nodari, Claudio Muneretto, Livio Dei Cas
Publikováno v:
Journal of the American College of Cardiology. 40(7):1248-1258
Objectives We compared the hemodynamic effects of dobutamine and enoximone administration before and after long-term beta-blocker therapy with metoprolol or carvedilol in patients with chronic heart failure (HF). Background Patients with HF on beta-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208fd3206b278f1b965b728d85c98fda
Autor:
Michael R. Bristow, Lawrence Petrovich, Marcus A. DeWood, Richard J. Gorczynski, Michael B. Higginbotham, Peter S. Rahko, Thierry H. LeJemtel, Robert L. Roden, Margo M. Schleman, Brian D. Lowes, G. William Dec, Alastair D. Robertson, Mark A. Greenberg
Publikováno v:
Journal of the American College of Cardiology. 36:501-508
OBJECTIVES This study was designed to evaluate the effects of low-dose enoximone on exercise capacity. BACKGROUND At higher doses the phosphodiesterase inhibitor, enoximone, has been shown to increase exercise capacity and decrease symptoms in heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b8c8ee1fdc8849f11346768f67d107
https://doi.org/10.1016/s0735-1097(00)00759-2
https://doi.org/10.1016/s0735-1097(00)00759-2