Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alastair D Lawson"'
Autor:
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2006192 (2018)
Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)-Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 k
Externí odkaz:
https://doaj.org/article/8aa07cda1edf4eacba469577557c2556
Autor:
Daniel, Lightwood, Victoria, O'Dowd, Bruce, Carrington, Vaclav, Veverka, Mark D, Carr, Markus, Tservistas, Alistair J, Henry, Bryan, Smith, Kerry, Tyson, Sabrina, Lamour, Marguerite, Bracher, Kaushik, Sarkar, Alison, Turner, Alastair D, Lawson, Tim, Bourne, Neil, Gozzard, Roger, Palframan
Publikováno v:
Journal of Molecular Biology. 425:577-593
We describe the discovery, engineering and characterisation of a highly potent anti-human interleukin (IL)-13 Fab fragment designed for administration by inhalation. The lead candidate molecule was generated via a novel antibody discovery process, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e220d3deb7766a555a5341b5e3028cc5
https://doi.org/10.1016/j.jmb.2012.11.036
https://doi.org/10.1016/j.jmb.2012.11.036
Autor:
James T, Heads, Ralph, Adams, Lena E, D'Hooghe, Matt J T, Page, David P, Humphreys, Andrew G, Popplewell, Alastair D, Lawson, Alistair J, Henry
Publikováno v:
Protein science : a publication of the Protein Society. 21(9)
The stability of therapeutic antibodies is a prime pharmaceutical concern. In this work we examined thermal stability differences between human IgG1 and IgG4 Fab domains containing the same variable regions using the thermofluor assay. It was found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b91594f8c05bc3a6edbcc356b56cdae
https://pubmed.ncbi.nlm.nih.gov/22761163
https://pubmed.ncbi.nlm.nih.gov/22761163