Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alastair Barton"'
Autor:
Alastair Barton, Zoltan K. Nagy, Paul Firth, Francesco Destro, Massimiliano Barolo, Mesfin Abdi, Erin Wood, Xin Feng, Simon Coleman, Vivian Wang
Publikováno v:
IFAC-PapersOnLine. 54:134-139
Within the recent modernization of pharmaceutical manufacturing, an important milestone consists in developing enabling technologies for end-to-end continuous production of drug products. Continuous filtration, washing and drying of active pharmaceut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265ecfd68c731c502a96a6337e3cfc19
https://doi.org/10.1016/j.ifacol.2021.08.231
https://doi.org/10.1016/j.ifacol.2021.08.231
Autor:
Simon Coleman, Sara Ottoboni, Muhid Shahid, Richard Sutherland, Alastair Barton, Christopher Steven, Chris John Price, Paul Firth, Elisabeth Meehan
Publikováno v:
Organic Process Research & Development
A key challenge during the transition from laboratory/small batch to continuous manufacturing is the development of a process strategy that can easily be adopted for a larger batch/continuous process. Industrial practice is to develop the isolation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44164922215901d3e1c50ff3fef2ba7d
https://doi.org/10.1021/acs.oprd.9b00512
https://doi.org/10.1021/acs.oprd.9b00512
Autor:
Davis Dunn, Dan Wood, Yiqing Claire Liu, Alastair Barton, Zoltan K. Nagy, Jonathon Speed, Mary Lipari, Paul Firth
Publikováno v:
Chemical Engineering Journal. 367:278-294
Crystallization, often as the final isolation and purification step in drug substance manufacturing, has substantial impact on downstream efficiency and final drug product quality. It is a critical but challenging step in developing end-to-end contin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::898b55c2432d86129e5cb95c703e8c83
https://doi.org/10.1016/j.cej.2019.02.129
https://doi.org/10.1016/j.cej.2019.02.129
Autor:
Zoltan K. Nagy, Francesco Destro, Erin Wood, Vivian Wang, Alastair Barton, Xin Feng, Simon Coleman, Paul Firth, Mesfin Abdi, Massimiliano Barolo, Inyoung Hur
This paper introduces a comprehensive mathematical model of a novel integrated filter-dryer carousel system, designed for continuously filtering, washing and drying a slurry stream into a crystals cake. The simulator includes models for dead-end filt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d2bcffaffc132539969b149e820415
http://hdl.handle.net/11577/3394493
http://hdl.handle.net/11577/3394493
Autor:
Alastair Barton, Mariam Siddique, Chris John Price, Sara Ottoboni, Marine Fraissinet, Simon Coleman, Paul A. Mulheran, Audrey Laux, Christopher Steven, Paul Firth, Marion Joannes
Publikováno v:
Organic Process Research & Development
Developing a continuous isolation process to produce a pure, dry, free-flowing active pharmaceutical ingredient (API) is the final barrier to the implementation of continuous end-to-end pharmaceutical manufacturing. Recent work has led to the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e6dcdad82f7a9d5cb5cd9b07b4e3d0
https://pubmed.ncbi.nlm.nih.gov/33250628
https://pubmed.ncbi.nlm.nih.gov/33250628
Publikováno v:
Chemical Engineering Journal. 351:498-505
Oscillatory flow strategies through baffled tubular reactors provide an efficient approach in improving process kinetics through enhanced micromixing and heat transfer. Known to have high surface area to volume ratios, oscillatory flow baffled reacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4b6a4775e3113c62d974db8e2acc16
https://doi.org/10.1016/j.cej.2018.06.029
https://doi.org/10.1016/j.cej.2018.06.029
Autor:
Elizabeth Meehan, Sara Ottoboni, Andy Mitchell, Alastair Barton, Furqan Tahir, Christopher Steven, Paul Firth, Chris John Price
Publikováno v:
University of Strathclyde
The lack of a commercial laboratory, pilot and small manufacturing scale dead end continuous filtration and drying unit it is a significant gap in the development of continuous pharmaceutical manufacturing processes for new active pharmaceutical ingr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ba39c38edb1d1bec3e3095bf888a7f
https://strathprints.strath.ac.uk/67073/1/Ottoboni_etal_JPS_2019_Development_of_a_novel_continuous_filtration_unit.pdf
https://strathprints.strath.ac.uk/67073/1/Ottoboni_etal_JPS_2019_Development_of_a_novel_continuous_filtration_unit.pdf
Publikováno v:
Chemical Engineering and Processing: Process Intensification. 108:212-219
As the pharmaceutical industry evolves and goes through the paradigm shift from batch to continuous manufacturing, innovative processes need to be developed to replace unit operations that have historically been batch operations. This requires innova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dcdf26ad483f459b6d62664d19a8c4e
https://doi.org/10.1016/j.cep.2016.08.006
https://doi.org/10.1016/j.cep.2016.08.006