Zobrazeno 1 - 10 of 190 pro vyhledávání: '"Alastair Aitken"'
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Multisite phosphorylation of the 80 kDa (MARCKS) protein kinase C substrate in C3H/10T1/2 fibroblasts. Quantitative analysis of individual sites by solid-phase microsequencing
Autor: Alastair Aitken, Bob Arness, H.Angel Manjarrez-Hernandez, Michele Learmonth, Steve Howell
A synthetic peptide, KKKKRFSFKKSFKLSGFSFKK, containing the phosphorylation sites of the acidic 80-87 kDa protein kinase C substrate was used to identify phosphopeptides in enzyme digests of this protein from mouse fibroblast C3H/10T1/2 cells. Stimula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2421542fec89cd91030632379484a6
https://doi.org/10.1016/0014-5793(92)80557-w
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3
Binding of 14-3-3 proteins to a single stranded oligodeoxynucleotide aptamer
Autor: Tom Brown, Alastair Aitken, Ross Stevenson, Robert Baxter, H. C. Baxter
A synthetic library of ca. 10(13) single stranded oligodeoxynucleotides, each comprising a randomized 40mer sequence and homogeneous 10mer flanking regions, was screened for binding to recombinant human 14-3-3gamma. A single aptamer, which showed sim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb150960d6f15d9753c42cad81b228b
https://ora.ox.ac.uk/objects/uuid:f8797c1a-0eb1-413b-85ec-43190df8416d
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4
Akademický článek
Plantar Warts And Athlete's Foot
Autor: Ross, Alastair Aitken
Publikováno v: The British Medical Journal, 1964 Dec 01. 2(5423), 1532-1532.
Externí odkaz: https://www.jstor.org/stable/25401374
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5
Post-translational modification of 14-3-3 isoforms and regulation of cellular function
Autor: Alastair Aitken
Publikováno v: Seminars in Cell & Developmental Biology. 22:673-680
14-3-3 is now well established as a family of dimeric proteins that can modulate interaction between proteins involved in a wide range of functions. In many cases, these proteins show a distinct preference for a particular isoform(s) of 14-3-3 and in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc82169f5ddc9a55672f53aa420f494
https://doi.org/10.1016/j.semcdb.2011.08.003
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6
The interaction between casein kinase Iα and 14-3-3 is phosphorylation dependent
Autor: Alastair Aitken, Helen Falconer, Thierry Dubois, Samuel Clokie, Shaun Mackie
Publikováno v: FEBS Journal. 276:6971-6984
We have previously shown that casein kinase (CK) Ia from mammalian brain phosphorylates 14-3-3 f and s isoforms on residue 233. In the present study, we show that CKIa associates with 14-3-3 both in vitro and in vivo. The interaction between CKIa and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ee7870d21638acb58b89639eda49491
https://doi.org/10.1111/j.1742-4658.2009.07405.x
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7
Identification of different isoforms of 14-3-3 protein family in human dermal and epidermal layers
Autor: Reza B. Jalili, Ruhangiz T. Kilani, Matthew J. Carr, Alastair Aitken, Abelardo Medina, Aziz Ghahary
Publikováno v: Molecular and Cellular Biochemistry. 314:161-169
We have previously demonstrated a high level of stratifin, also known as 14-3-3 sigma in differentiated keratinocyte cell lysate and conditioned medium (CM). In this study, we asked the question of whether other 14-3-3 isoforms are expressed in human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c1a1934545e1a889ec22ea9cb173dc
https://doi.org/10.1007/s11010-008-9777-6
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8
Down-regulation of 14-3-3ζ suppresses anchorage-independent growth of lung cancer cells through anoikis activation
Autor: Hae Ryoun Park, Leon Bernal-Mizrachi, Alastair Aitken, Fadlo R. Khuri, Yuhong Du, Haian Fu, Jing Zhao, Shi-Yong Sun, Zenggang Li
Publikováno v: Li, Z G, Zhao, J, Du, Y H, Park, H R, Sun, S Y, Bernal-Mizrachi, L, Aitken, A, Khuri, F R & Fu, H A 2008, ' Down-regulation of 14-3-3 zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation ', Proceedings of the National Academy of Sciences, vol. 105, no. 1, pp. 162-167 . https://doi.org/10.1073/pnas.0710905105
The family of 14-3-3 proteins has emerged as critical regulators of diverse cellular responses under both physiological and pathological conditions. Here, we report an important role of 14-3-3 in tumorigenesis through a mechanism that involves anoiki
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c41610673a2dd41892a2a4e5ed0174
https://doi.org/10.1073/pnas.0710905105
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9
Changes in protein expression in the rat medial vestibular nuclei during vestibular compensation
Autor: Duncan Short, Alastair Aitken, Peter W. Flatman, Janet M. Paterson, Mayank B. Dutia, Jonathan R. Seckl
Publikováno v: The Journal of Physiology. 575:777-788
The molecular mechanisms of neural and synaptic plasticity in the vestibular nuclei during ‘vestibular compensation’, the behavioural recovery that follows deafferentation of one inner ear, are largely unknown. In this study we have used differen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb06d7caa7ba362f3d2513b95fa43c93
https://doi.org/10.1113/jphysiol.2006.112409
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10
Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease
Autor: Shaun Mackie, Alastair Aitken
Publikováno v: FEBS Journal. 272:4202-4210
We isolated two novel 14-3-3 binding proteins using 14-3-3 ζ as bait in a yeast two-hybrid screen of a human brain cDNA library. One of these encoded the C-terminus of a neural specific armadillo-repeat protein, δ-catenin (neural plakophilin-relate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::889f7a8b4b87b571d87b603e16572bc6
https://doi.org/10.1111/j.1742-4658.2005.04832.x
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