Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alastair, Hotblack"'
Autor:
Harry Dolstra, Claire Roddie, Martin A Pule, Vedika Mehra, Giulia Agliardi, Juliana Dias Alves Pinto, Manar S Shafat, Amaia Cadinanos Garai, Louisa Green, Alastair Hotblack, Fred Arce Vargas, Karl S Peggs, Anniek B van der Waart
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background AUTO1 is a fast off-rate CD19-targeting chimeric antigen receptor (CAR), which has been successfully tested in adult lymphoblastic leukemia. Tscm/Tcm-enriched CAR-T populations confer the best expansion and persistence, but Tscm/Tcm number
Externí odkaz:
https://doaj.org/article/304fa86b5512400a84f30e4d82b38677
Autor:
Alastair Hotblack, Evangelia K. Kokalaki, Morgan J. Palton, Gordon Weng-Kit Cheung, Iwan P. Williams, Somayya Manzoor, Thomas I. Grothier, Alice Piapi, Valeria Fiaccadori, Patrycja Wawrzyniecka, Harriet A. Roddy, Giulia Agliardi, Claire Roddie, Shimobi Onuoha, Simon Thomas, Shaun Cordoba, Martin Pule
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular
Externí odkaz:
https://doaj.org/article/dee4a8da64cb4a34bd085ebded529484
Autor:
Giulia Agliardi, Anna Rita Liuzzi, Alastair Hotblack, Donatella De Feo, Nicolás Núñez, Cassandra L. Stowe, Ekaterina Friebel, Francesco Nannini, Lukas Rindlisbacher, Thomas A. Roberts, Rajiv Ramasawmy, Iwan P. Williams, Bernard M. Siow, Mark F. Lythgoe, Tammy L. Kalber, Sergio A. Quezada, Martin A. Pule, Sonia Tugues, Karin Straathof, Burkhard Becher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Glioblastoma multiform (GBM) is a common and aggressive type of primary brain cancer that currently has no effective therapy. Here, the authors show, using a mouse GBM model and EGFRvIII-targeting chimeric antigen receptor (CAR)-T cells, that Intratu
Externí odkaz:
https://doaj.org/article/b2005a4f42464b199597399076f130a8
Autor:
Cassandra L Stowe, Thomas A Burley, Helen Allan, Maria Vinci, Gabriela Kramer-Marek, Daniela M Ciobota, Gary N Parkinson, Tara L Southworth, Giulia Agliardi, Alastair Hotblack, Mark F Lythgoe, Bruce R Branchini, Tammy L Kalber, James C Anderson, Martin A Pule
Publikováno v:
eLife, Vol 8 (2019)
Bioluminescence imaging (BLI) is ubiquitous in scientific research for the sensitive tracking of biological processes in small animal models. However, due to the attenuation of visible light by tissue, and the limited set of near-infrared bioluminesc
Externí odkaz:
https://doaj.org/article/28633a3c3ec14220bcd7ff7a3ce49ce3
Autor:
Alastair, Hotblack, Karin, Straathof
Publikováno v:
Cancer Cell
Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cells expressing Chimeric Antigen Receptors (CAR) targeting glypican-2 (GPC2), a fetal antigen expressed
Autor:
Angelika Holler, Mathias Zech, Sara Ghorashian, Rebecca Pike, Alastair Hotblack, Pedro Veliça, Shao-An Xue, Ronjon Chakraverty, Emma C. Morris, Hans J. Stauss
Publikováno v:
Haematologica, Vol 101, Iss 4 (2016)
Due to the lack of specificity for tumor antigens, allogeneic T-cell therapy is associated with graft-versus-host disease. Enhancing the anti-tumor specificity while reducing the graft-versus-host disease risk of allogeneic T cells has remained a res
Externí odkaz:
https://doaj.org/article/832853b6cf9444438aff1b61e124f0a5
Autor:
Valeria Fiaccadori, Morgan J. Palton, Evangelia Kokalaki, Shaun Cordoba, Harriet Roddy, Shimobi Onuoha, Gordon Cheung, Iwan P. Williams, Claire Roddie, Alastair Hotblack, Giulia Agliardi, Thomas Grothier, Martin Pule, Patrycja Wawrzyniecka, Somayya Manzoor, Simon Thomas, Alice Piapi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Chimeric antigen receptor (CAR) T cells are a promising form of cancer immunotherapy, although they are often associated with severe toxicities. Here, we present a split-CAR design incorporating separate antigen recognition and intracellular signalin
Autor:
Alastair Hotblack, Patrycja Wawrzyniecka, Gordon Weng-Kit Cheng, Francesco Nannini, Martin Pule, Karin Straathof
Publikováno v:
Neuro-Oncology. 24:i85-i85
T-cells engineered with a chimeric antigen receptor (CAR) to acquire tumour specificity provide a possible new treatment approach for childhood brain tumours. Durable clinical remissions have been achieved with CD19-directed CAR T-cells in refractory
Autor:
Cassandra L Stowe, Francesco Nannini, Lukas Rindlisbacher, Donatella De Feo, Karin Straathof, Martin Pule, Bernard Siow, Ekaterina Friebel, Sonia Tugues, Giulia Agliardi, Alastair Hotblack, Rajiv Ramasawmy, Iwan P. Williams, Anna Rita Liuzzi, Tammy L. Kalber, Thomas A. Roberts, Sergio A. Quezada, Nicolás Gonzalo Núñez, Burkhard Becher, Mark F. Lythgoe
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR)-based immunotherapy represents a promising therapeutic approach, but it i
Autor:
Gabriela Kramer-Marek, Helen Allan, Alastair Hotblack, Tara L. Southworth, James C. Anderson, Giulia Agliardi, Bruce R. Branchini, Thomas A Burley, Cassandra L Stowe, Gary N. Parkinson, Mark F. Lythgoe, Martin Pule, Maria Vinci, Daniela M. Ciobota, Tammy L. Kalber
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Bioluminescence imaging (BLI) is ubiquitous in scientific research for the sensitive tracking of biological processes in small animal models. However, due to the attenuation of visible light by tissue, and the limited set of near-infrared bioluminesc