NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

Autor: Aled J. Parry, Matthew Hoare, Dóra Bihary, Robert Hänsel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D’Santos, I. Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A. Samarajiwa, Masashi Narita

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.

Externí odkaz: https://doaj.org/article/0085ce66095d4d51b112d11335833dab

New insights into the role of FOXA1- HNF4 axis in Pancreatic Cancer

Autor: Shalini V. Rao, Lisa Young, Danya Cheeseman, Stephanie Mack, Jill Temple, Chandra Shekar Reddy Chilamakuri, Evangelia Papachristou, Amy Smith, Dominique-Laurent Couturier, Romana Ranftl, null Michael Gill, Duncan Jodrell, Alasdair Russell, Igor Chernukhin, Jason Carroll

Publikováno v: Pancreatology. 23:e10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::201c3d3a3624442918b827a54bec7ce4
https://doi.org/10.1016/j.pan.2023.04.031

IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

Autor: Jason S. Carroll, Stacey E. P. Joosten, Rasmus Siersbæk, Andrew R. Green, Wilbert Zwart, Danya Cheeseman, Igor Chernukhin, Emad A. Rakha, Rebecca Broome, Evangelia K. Papachristou, Sankari Nagarajan, Soleilmane Omarjee, Ruben Alvarez-Fernandez, Valentina Scabia, Julia P. G. Jones, Clive D'Santos, Kamal Kishore, Simon J Johnston, Sanjeev Kumar, Silvia Glont, Cathrin Brisken, Alasdair Russell, Sarah J. Aitken

Publikováno v: Cancer Cell, 38(3), 412-423.e9. Cell Press
Cancer Cell
Nagarajan, S 2020, ' IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis ', Cancer Cell, vol. 38, no. 3, pp. 412-423.e9 . https://doi.org/10.1016/j.ccell.2020.06.007

The cytokine interleukin-6 (IL6) and its downstream effector STAT3 constitute a key oncogenic pathway, which has been thought to be functionally connected to estrogen receptor α (ER) in breast cancer. We demonstrate that IL6/STAT3 signaling drives m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c6a2f9f6f6c6701d97d8fee070656e
https://research.tue.nl/nl/publications/9a7ad21c-f148-4b84-8a85-7fca9a6c5d2c

The use of CRISPR for variant specificity in the genetic diagnosis of primary immunodeficiency disease (PID)

Autor: Amy Smith, Alasdair Russell, James Thaventhiran, Sarah Spencer, Tiffeney Mann

The functional validation of genetic variants of uncertain significance (VUS) found in PID patients by next-generation sequencing has traditionally been carried out in model systems that are susceptible to artefact. We use CRISPR correction of primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cab4739cd5f89106fcdaf6cc08843e4
https://doi.org/10.1101/804732

GenEditID: an open-access platform for the high-throughput identification of CRISPR edited cell clones

Autor: Rasmus Siersbæk, Richard Bowers, Florian T. Merkle, Jason S. Carroll, Matthew D. Eldridge, Ruben Alvarez-Fernandez, Ying Xue, Alasdair Russell, Anne Pajon, Y. C. Loraine Tung, Chandra Sekhar Reddy Chilamakuri

CRISPR-Cas9-based gene editing is a powerful tool to reveal genotype-phenotype relationships, but identifying cell clones carrying desired edits remains challenging. To address this issue we developed GenEditID, a flexible, open-access platform for s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717d631039948874079faacfc57d8b28
https://doi.org/10.1101/657650