EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation

Autor: Rachel S. Cooper, Catherine Sutherland, Linda M. Smith, Graeme Cowan, Mark Barnett, Donna Mitchell, Colin McLean, Stuart Imlach, Alan Hayes, Sharon Zahra, Champa Manchanayake, Mark A. Vickers, Gerry Graham, Neil W. A. McGowan, Marc L. Turner, John D. M. Campbell, Alasdair R. Fraser

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Adoptive immunotherapy with Epstein–Barr virus (EBV)-specific T cells is an effective treatment for relapsed or refractory EBV-induced post-transplant lymphoproliferative disorders (PTLD) with overall survival rates of up to 69%. EBV-specific T cel

Externí odkaz: https://doaj.org/article/0cb45f6c1180476fa75a74a1fdc66481

Study protocol: a multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH)

Autor: Catriona Graham, John F Dillon, Scott Semple, Neil Lachlan, Alasdair R Fraser, Jonathan Andrew Fallowfield, Francesca Moroni, Mark Macmillan, Thomas Manship, Stuart J Forbes, Paul Noel Brennan, Alison Glover, David M Morris, Chloe Pass, Neil W A McGowan, Marc L Turner, John D M Campbell

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Introduction Liver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or proregenerative medi

Externí odkaz: https://doaj.org/article/89f7b18180ca494fa34b4ea6b54326f8

Study protocol: a multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH)

Autor: Thomas Manship, Mark T. Macmillan, Francesca Moroni, John M. Campbell, Paul Noel Brennan, Alison Glover, Alasdair R. Fraser, John F. Dillon, Stuart J. Forbes, Neil W. A. McGowan, Neil Lachlan, David M. Morris, Marc Turner, Chloe Pass, Jonathan A. Fallowfield, Catriona Graham, Scott Semple

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open
Brennan, P N, MacMillan, M, Manship, T, Moroni, F, Glover, A, Graham, C, Semple, S, Morris, D M, Fraser, A R, Pass, C, McGowan, N W A, Turner, M L, Lachlan, N, Dillon, J F, Campbell, J D M, Fallowfield, J A & Forbes, S J 2021, ' Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) ', BMJ Open . https://doi.org/DOI: 10.1136/bmjopen-2021-053190

IntroductionLiver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or proregenerative medic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86c8ea090cc876ae1e5472c36a41f5e
https://bmjopen.bmj.com/content/11/11/e053190.full

Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

Autor: John M. Hallett, Sofia Ferreira-Gonzalez, Tak Yung Man, Alastair M. Kilpatrick, Hannah Esser, Kayleigh Thirlwell, Mark T. Macmillan, Daniel Rodrigo-Torres, Benjamin J. Dwyer, Victoria L. Gadd, Candice Ashmore-Harris, Wei-Yu Lu, John P. Thomson, Maurits A. Jansen, Eoghan O’Duibhir, Philip J. Starkey Lewis, Lara Campana, Rhona E. Aird, Thomas S.R. Bate, Alasdair R. Fraser, John D.M. Campbell, Gabriel C. Oniscu, David C. Hay, Anthony Callanan, Stuart J. Forbes

Publikováno v: Hallett, J, Ferreira-Gonzalez, S, Man, J, Kilpatrick, A, Esser, H, Thirwell, K, Macmillan, M, Rodrigo Torres, D, Dwyer, B, Gadd, V, Ashmore-Harris, C, Lu, W-Y, Thomson, J, Jansen, M, O'Duibhir, E, Starkey Lewis, P, Campana, L, Aird, R, Bate, T, Fraser, A R, Campbell, J D M, Oniscu, G C, Hay, D C, Callanan, A & Forbes, S J 2022, ' Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease ', Cell Stem Cell . https://doi.org/10.1016/j.stem.2022.02.006

Biliary diseases can cause inflammation, fibrosis, bile duct destruction, and eventually liver failure. There are no curative treatments for biliary disease except for liver transplantation. New therapies are urgently required. We have therefore puri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ac8dd45230457bbbf0f9ff444a375c
https://pubmed.ncbi.nlm.nih.gov/35245462

Cytometric analysis of T cell phenotype using cytokine profiling for improved manufacturing of an EBV-specific T cell therapy

Autor: Gwen Wilkie, Rachel S Cooper, Mark A. Vickers, Alasdair R. Fraser, John D.M. Campbell, Aleksandra Kowalczuk, Marc Turner

Publikováno v: Clinical and Experimental Immunology

Adoptive immunotherapy using Epstein–Barr Virus (EBV)‐specific T cells is a potentially curative treatment for patients with EBV‐related malignancies where other clinical options have proved ineffective. We describe improved good manufacturing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01cd648443142e6cf2afbe5a41fe790
https://doi.org/10.22541/au.161002473.32537816/v1