Výsledky vyhledávání - "Alasdair P. Macgowan"

The relationship between minimum inhibitory concentration and 28 day mortality in patients with a Gram-negative bloodstream infection: an analysis of data from a cohort study (BSI-FOO)

Autor: Rebecca N Evans, Jessica Harris, Chris A Rogers, Alasdair P MacGowan

Publikováno v: JAC-Antimicrobial Resistance. 5

Objectives To explore the association between MIC/EUCAST breakpoint ratio and 28 day mortality in patients with a Gram-negative bloodstream infection (BSI). Methods Using data from the Bloodstream Infection—Focus on Outcomes (BSI-FOO) observational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7424f0f3cfd313b988e84ed1d629b33c
https://doi.org/10.1093/jacamr/dlad009

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617. Pharmacodynamics of Ceftolozane-Tazobactam (C/T) as Monotherapy and in Combination with Tobramycin or Fosfomycin Against P.aeruginosa with C/T MICs at or Above 4mg/L

Autor: Alasdair P MacGowan, Marie Attwood, Pippa Griffin, Alan Noel

Publikováno v: Open Forum Infectious Diseases. 9

Background Ceftolozane (C/T) is widely used in clinical practice to treat difficult and/or multidrug resistant Pseudomonas aeruginosa (Pa). However, clinical data is absent on the use of C/T therapy to treat Pa strains with C/T MICs ≥ 4mg/L, that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c37a23e5aaeda3a911a15ada4219b697
https://doi.org/10.1093/ofid/ofac492.669

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The effect of duration of therapy for treatment of Staphylococcus aureus blood stream infection:an application of cloning to deal with immortal-time bias in an analysis of data from a cohort study (BSI-FOO)

Autor: Rebecca N Evans, Jessica Harris, Chris A Rogers, Alasdair P Macgowan

Publikováno v: Evans, R N, Harris, J, Rogers, C A & MacGowan, A P 2022, ' The effect of duration of therapy for treatment of Staphylococcus aureus blood stream infection : an application of cloning to deal with immortal-time bias in an analysis of data from a cohort study (BSI-FOO) ', Journal of Antimicrobial Chemotherapy, vol. 78, no. 1, pp. 196–204 . https://doi.org/10.1093/jac/dkac374

Objective To estimate the effect of treatment duration on in-hospital mortality in patients with Staphylococcus aureus blood stream infection and demonstrate the biases that can arise when immortal-time bias is ignored. Exposure We compared three tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04108269d1848a412094f4e92936fa3e
https://research-information.bris.ac.uk/en/publications/f6073278-b9c8-4a12-b2ed-2feee94b5bc4

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The pharmacodynamics of minocycline alone and in combination with rifampicin against Staphylococcus aureus studied in an in vitro pharmacokinetic model of infection

Autor: Marie Attwood, Alasdair P. MacGowan, Alan R. Noel, Karen E. Bowker

Publikováno v: Journal of Antimicrobial Chemotherapy. 76:1840-1844

Background Tetracyclines are widely used as oral therapy of MRSA infection, however, the pharmacodynamic underpinning is absent. Objectives We employed an in vitro pharmacokinetic model to study the pharmacodynamics of minocycline alone and in combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096a01f4555d702bbf5a5244f1124bc4
https://doi.org/10.1093/jac/dkab112

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Risk factors for enterococcal urinary tract infections: a multinational, retrospective cohort study

Autor: Christiane Vank, Aina Gomila-Grange, Study Sites, Irith Wiegand, Tanya Babich, Leonard Leibovici, Leo van den Heuvel, Miquel Pujol, Jordi Carratalà, Noa Eliakim-Raz, Sally Grier, Evelyn Shaw, Adi Turjeman, Ibironke Addy, Alasdair P. MacGowan, Nienke Cuperus, Cuong Vuong

Publikováno v: European Journal of Clinical Microbiology & Infectious Diseases. 40:2005-2010

Complicated urinary tract infection (cUTI) is a frequent cause of morbidity. In this multinational retrospective cohort study, we aimed to demonstrate risk factors for enterococcal UTI. Univariate and multivariate analyses of risk factors for enteroc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e2507b6e8d821142a2223af6cd2e842
https://doi.org/10.1007/s10096-021-04207-4

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Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

Autor: Timothy M Rawson, Richard C Wilson, Luke S P Moore, Alasdair P Macgowan, Andrew M Lovering, Mark Bayliss, Mathew Kyriakides, Mark Gilchrist, Jason A Roberts, William W Hope, Alison H Holmes

Publikováno v: Open Forum Infectious Diseases

This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicilli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f93c86d383000b1e0d5fc2ffceeb719
https://doi.org/10.1093/ofid/ofab573

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Cost-effectiveness of rapid laboratory-based mass-spectrometry diagnosis of bloodstream infection: evidence from the RAPIDO randomised controlled trial

Autor: Katie Pike, Rosy Reynolds, Alasdair P. MacGowan, Padraig Dixon, Margaret Stoddart, William Hollingworth

Publikováno v: BMJ Open
Dixon, P, Hollingworth, W, Pike, K E, Reynolds, R A, Stoddart, M & MacGowan, A 2021, ' Cost-effectiveness of rapid laboratory-based mass-spectrometry diagnosis of bloodstream infection : evidence from the RAPIDO randomised controlled trial ', BMJ Open, vol. 11, no. 10, 044623 . https://doi.org/10.1136/bmjopen-2020-044623
BMJ Open, Vol 11, Iss 10 (2021)

Objectives and interventionBloodstream infection, the presence of viable micro-organisms in the blood, is a prevalent clinical event associated with substantial mortality. Patient outcomes may be improved when the causative micro-organism is identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e9790fa72149297f9004f99f06c67f
http://europepmc.org/articles/PMC8524273

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