Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

Autor: Irmgard Tegeder, Ruud Hovius, Nick Andrews, Katarzyna Irena Gorska, Michael Costigan, Olusegun Babaniyi, Clifford J. Woolf, Lee Barrett, Priscilla Riva, Nerea Ferreirós, Giulia Miracca, Kelly Duong, Alasdair M Naylor, Kai Johnsson, Alexandra Latini, Jian Zhong, Surawee Chuaiphichai, Michio W. Painter, Julian Blagg, Shane J. F. Cronin, Carla Romero, Masahide Fujita, Aline Pertile Remor, Josef M. Penninger, Keith M. Channon, Alban Latremoliere

Publikováno v: Neuron

SummaryHuman genetic studies have revealed an association between GTP cyclohydrolase 1 polymorphisms, which decrease tetrahydrobiopterin (BH4) levels, and reduced pain in patients. We now show that excessive BH4 is produced in mice by both axotomized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf6e9012459c3f23a7bd0ac4b57c7fa

Endocrine Actions of Central Neuropeptide Y in the Ewe: Activation of the Hypothalamo-Pituitary-Adrenal Axis by Exogenous Neuropeptide Y and Role of Endogenous Neuropeptide Y in the Secretion of Luteinizing Hormone During the Oestrous Cycle

Autor: Dennis W. Lincoln, Duncan W.F. Porter, Alan S. McNeilly, Alasdair M. Naylor

Publikováno v: Journal of Neuroendocrinology. 5:163-174

Neurons immunoreactive for neuropeptide Y (NPY) are abundant in the hypophysiotrophic areas of the brain. In particular, there is considerable anatomical evidence for the influence of this neuropeptide on the reproductive and hypothalamo-pituitary-ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559b4ce623125692cc40d41ac103c323
https://doi.org/10.1111/j.1365-2826.1993.tb00377.x

Contents, Vol. 51, 1990

Autor: Pilar Tamayo, Dennis W. Lincoln, Tsuei-Chu Liu, Barbara J. Reaves, Krzysztof Lyson, Kenjiro Mori, Banasree Das, Shigeo Nakaishi, Joachim Michel, Samuel M. McCann, Miklós Palkovits, Duncan W.F. Porter, Marcelo Moraes Valença, Alasdair M. Naylor, Lloyd D. Flicker, Domingos L.W. Picanço-Diniz, Zbigniew Krawczyk, Hanna Pisarek, Alain Sarrieau, Carlos Iñiguez, Rémi Quirion, Assem Fahim, Angela Barini, Jarmo T. Laitinen, Laura De Marinis, Michael J. Meaney, Gonzalo Martínez de la Escalera, Samarthji Lal, Desta R. Packan, Andrzej Stawowy, Paul W. Sylvester, Celso Rodrigues Franci, Janete Aparecida Anselmo-Franci, G.L. Jackson, Yoshikatsu Hirai, Henryk Stepien, Richard F. Weick, August Heidland, Karen P. Briski, Priscilla S. Dannies, André Olivier, John P. Chang, Joaquín De Juan, Manuel J. Gayoso, Paolo Zuppi, Valeria Rettori, Enrique Romero, Robert M. Sapolsky, Detlev Ganten, Antonio Mancini, Kei Li Yu, Sunao Tamai, José Antunes-Rodrigues, Richard I. Weiner, Concetta Fiumara, Helmut Geiger, Anderson On Lam Wong, John B. Mitchell, Gabriella Flügge, Yoshiyuki Naito, Udo Bahner, Hiroo Imura, Juan M. Saavedra, Richard E. Peter, Junichi Fukata, Katherine M. Stobie, Francesco Calabró, C. D'Amico, Yoshikatsu Nakai

Publikováno v: Neuroendocrinology. 51:I-VIII

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a86463163b3ac25eccafbeeeef2a08ff
https://doi.org/10.1159/000125399

An investigation of the effects of zaprinast, a PDE inhibitor, on the nitrergic control of the urethra in anaesthetized female rats

Autor: Alexandra, Wibberley, Philip A, Nunn, Alasdair M, Naylor, Andrew G, Ramage

Publikováno v: British journal of pharmacology. 136(3)

1. The effects of L-NAME and zaprinast were investigated (i.v.) on reflex-evoked changes in bladder and urethral pressures in urethane-anaesthetized female rats. 2. L-NAME attenuated reflex-evoked urethral relaxations (65+/-10%), while zaprinast pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19bd6c77f00b9ab85eb3198d31552bfd
https://pubmed.ncbi.nlm.nih.gov/12023943

Interactions between neuropeptide Y, luteinizing hormone-releasing hormone and estradiol in the control of luteinizing hormone release from cultured ovine pituitary cells

Autor: Barbara J.M. Graham, A. Nigel Brooks, Alasdair M. Naylor

Publikováno v: Peptides. 12(2)

This study used pituitary cells in culture firstly to test the hypothesis that NPY may augment the pituitary LH response to LHRH and secondly to determine whether this interaction is dependent on the presence of estradiol. LHRH (10 −10 –10 −6 M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d66ee481d0638a73800ac555a5720e
https://pubmed.ncbi.nlm.nih.gov/2067991