Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Alasdair Leslie"'
Autor:
Bridgette M. Cumming, Kelvin W. Addicott, Fernanda Maruri, Vanessa Pillay, Rukaya Asmal, Sashen Moodley, Beatriz Barreto-Durate, Mariana Araújo-Pereira, Matilda Mazibuko, Zoey Mhlane, Nikiwe Mbatha, Khadija Khan, Senamile Makhari, Farina Karim, Lauren Peetluk, Alexander S. Pym, Mahomed Yunus S. Moosa, Yuri F. van der Heijden, Timothy S. Sterling, Bruno B. Andrade, Alasdair Leslie, Adrie J. C. Steyn
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The impact of human pulmonary tuberculosis (TB) on the bioenergetic metabolism of circulating immune cells remains elusive, as does the resolution of these effects with TB treatment. In this study, the rates of oxidative phosphorylation (OXPHOS) and
Externí odkaz:
https://doaj.org/article/0f78e27f5bdc4e1d914413ad4f2e60ab
Autor:
Aashray K. Gupta, Joshua G. Kovoor, Alasdair Leslie, Peter Litwin, Brandon Stretton, Ammar Zaka, Pramesh Kovoor, Stephen Bacchi, Jayme S. Bennetts, Guy J. Maddern
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Aspirin's role in secondary prevention for patients with known coronary artery disease (CAD) is well established, validated by numerous landmark trials over the past several decades. However, its perioperative use in coronary artery bypass graft (CAB
Externí odkaz:
https://doaj.org/article/1b369f0d6b8844d6939895001db839d3
Autor:
Shepherd Nhamoyebonde, Mark Chambers, Lerato Ndlovu, Farina Karim, Matilda Mazibuko, Zoey Mhlane, Lindiwe Madziwa, Yunus Moosa, Sashen Moodley, Monjurul Hoque, Alasdair Leslie
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionNeutrophils play a complex and important role in the immunopathology of TB. Data suggest they are protective during early infection but become a main driver of immunopathology if infection progresses to active disease. Neutrophils are now
Externí odkaz:
https://doaj.org/article/d18491f9235746e3b939ef9df4997977
Autor:
Robert G. E. Krause, Thandeka Moyo-Gwete, Simone I. Richardson, Zanele Makhado, Nelia P. Manamela, Tandile Hermanus, Nonhlanhla N. Mkhize, Roanne Keeton, Ntombi Benede, Mathilda Mennen, Sango Skelem, Farina Karim, Khadija Khan, Catherine Riou, Ntobeko A. B. Ntusi, Ameena Goga, Glenda Gray, Willem Hanekom, Nigel Garrett, Linda-Gail Bekker, Andreas Groll, Alex Sigal, Penny L. Moore, Wendy A. Burgers, Alasdair Leslie
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Neutralizing antibodies strongly correlate with protection for COVID-19 vaccines, but the corresponding memory B cells that form to protect against future infection are relatively understudied. Here we examine the effect of prior SARS-CoV-2
Externí odkaz:
https://doaj.org/article/03b1ff7327134610b895e90b51a563cb
Autor:
Mohamed Ahmed, Jared Mackenzie, Liku Tezera, Robert Krause, Barry Truebody, Diana Garay-Baquero, Andres Vallejo, Katya Govender, John Adamson, Hayden Fisher, Jonathan W. Essex, Salah Mansour, Paul Elkington, Adrie J. C. Steyn, Alasdair Leslie
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Mycobacterium tuberculosis senses IFN-γ via the membrane protein MmpL10, which results in stimulation of bacterial respiration and virulence gene expression, worsens infection and paradoxically prevents the formation of isoniazid tolerant persisters
Externí odkaz:
https://doaj.org/article/46f025f3b82648ada03fe8702e70e007
Autor:
Vinicius Vieira, Nicholas Lim, Alveera Singh, Ellen Leitman, Reena Dsouza, Emily Adland, Maximilian Muenchhoff, Julia Roider, Miguel Marin Lopez, Julieta Carabelli, Jennifer Giandhari, Andreas Groll, Pieter Jooste, Julia G. Prado, Christina Thobakgale, Krista Dong, Photini Kiepiela, Andrew J. Prendergast, Gareth Tudor-Williams, John Frater, Bruce D. Walker, Thumbi Ndung’u, Veron Ramsuran, Alasdair Leslie, Henrik N. Kløverpris, Philip Goulder
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
HIV nonprogression despite persistent viremia is rare among adults who are naive to antiretroviral therapy (ART) but relatively common among ART-naive children. Previous studies indicate that ART-naive pediatric slow progressors (PSPs) adopt immune e
Externí odkaz:
https://doaj.org/article/c853642a4fad494d92227bb92d5c7838
Autor:
Robert Krause, Jumari Snyman, Hwa Shi-Hsia, Daniel Muema, Farina Karim, Yashica Ganga, Abigail Ngoepe, Yenzekile Zungu, Inbal Gazy, Mallory Bernstein, Khadija Khan, Matilda Mazibuko, Ntombifuthi Mthabela, Dirhona Ramjit, COMMIT-KZN Team, Oliver Limbo, Joseph Jardine, Devin Sok, Ian A Wilson, Willem Hanekom, Alex Sigal, Henrik Kløverpris, Thumbi Ndung'u, Alasdair Leslie
Publikováno v:
eLife, Vol 11 (2022)
Background: HIV infection dysregulates the B cell compartment, affecting memory B cell formation and the antibody response to infection and vaccination. Understanding the B cell response to SARS-CoV-2 in people living with HIV (PLWH) may explain the
Externí odkaz:
https://doaj.org/article/9e85d121845c4a7ba7f4e109a7030fe9
Autor:
Rabiah Fardoos, Sarah K. Nyquist, Osaretin E. Asowata, Samuel W. Kazer, Alveera Singh, Abigail Ngoepe, Jennifer Giandhari, Ntombifuthi Mthabela, Dirhona Ramjit, Samita Singh, Farina Karim, Søren Buus, Frank Anderson, J. Zachary Porterfield, Andile L. Sibiya, Rishan Bipath, Kumeshan Moodley, Warren Kuhn, Bonnie Berger, Son Nguyen, Tulio de Oliveira, Thumbi Ndung’u, Philip Goulder, Alex K. Shalek, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of gr
Externí odkaz:
https://doaj.org/article/2214efc1e1c44dd5be878bda8705a958
Autor:
María B. Arriaga, Farina Karim, Artur T.L. Queiroz, Mariana Araújo-Pereira, Beatriz Barreto-Duarte, Caio Sales, Mahomed-Yunus S. Moosa, Matilda Mazibuko, Ginger L. Milne, Fernanda Maruri, Carlos Henrique Serezani, John R. Koethe, Marina C. Figueiredo, Afrânio L. Kritski, Marcelo Cordeiro-Santos, Valeria C. Rolla, Timothy R. Sterling, Alasdair Leslie, Bruno B. Andrade, the RePORT Brazil and South Africa consortia, Alice M. S. Andrade, Michael S. Rocha, Vanessa Nascimento, Juan M. Cubillos-Angulo, Hayna Malta-Santos, Jéssica Rebouças-Silva, Sayonara M. Viana, Saulo R. N. Santos, André Ramos, Alysson G. Costa, Jaquelane Silva, Jamile G. de Oliveira, Secretaria, Aline Benjamin, Adriano Gomes-Silva, Flavia M. Sant’Anna, Francine P. Ignácio, Maria Cristina Lourenço, Elisangela C. Silva, Adriana S. R. Moreira, Mayla Mello
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundOxidized lipid mediators such as eicosanoids play a central role in the inflammatory response associated with tuberculosis (TB) pathogenesis. Diabetes mellitus (DM) leads to marked changes in lipid mediators in persons with TB. However, the
Externí odkaz:
https://doaj.org/article/435ed61dfa08482680dc31a82c9cdb0f
Autor:
Rabiah Fardoos, Osaretin E. Asowata, Nicholas Herbert, Sarah K. Nyquist, Yenzekile Zungu, Alveera Singh, Abigail Ngoepe, Ian M. Mbano, Ntombifuthi Mthabela, Dirhona Ramjit, Farina Karim, Warren Kuhn, Fusi G. Madela, Vukani T. Manzini, Frank Anderson, Bonnie Berger, Tune H. Pers, Alex K. Shalek, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
SARS-CoV-2 infects epithelial cells of the human gastrointestinal (GI) tract and causes related symptoms. HIV infection impairs gut homeostasis and is associated with an increased risk of COVID-19 fatality. To investigate the potential link between t
Externí odkaz:
https://doaj.org/article/393306dcc3c24409b817c7996c447f25