Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alasdair J. Allan"'
Autor:
Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon, Loranne Agius, Quentin M. Anstee, Kirill E. Volynski, Dimitri M. Kullmann, Sara Wells, Lydia Teboul
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing have led to the use of long single-stranded DNA (lssDNA) molecules for generating conditional
Externí odkaz:
https://doaj.org/article/ee1cca96cdab4bc9a1b2e27269d0610a
Autor:
Christopher V McCabe, Peter D Price, Gemma F Codner, Alasdair J Allan, Adam Caulder, Skevoulla Christou, Jorik Loeffler, Matthew Mackenzie, Elke Malzer, Joffrey Mianné, Krystian J Nowicki, Edward J O'Neill, Fran J Pike, Marie Hutchison, Benoit Petit-Demoulière, Michelle E Stewart, Hilary Gates, Sara Wells, Nicholas D Sanderson, Lydia Teboul
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011187 (2024)
BackgroundRecent developments in CRISPR/Cas9 genome-editing tools have facilitated the introduction of precise alleles, including genetic intervals spanning several kilobases, directly into the embryo. However, the introduction of donor templates, vi
Externí odkaz:
https://doaj.org/article/bb312da1ed8649b9bf1f17a2c3bba609
Autor:
Matthew J Higgs, Anna E Webberley, Alasdair J Allan, Moaz Talat, Rosalind M John, Anthony R Isles
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010961 (2023)
Imprinted genes are subject to germline epigenetic modification resulting in parental-specific allelic silencing. Although genomic imprinting is thought to be important for maternal behaviour, this idea is based on serendipitous findings from a small
Externí odkaz:
https://doaj.org/article/1f2126a47df8452f857b46edee61ac03
Autor:
Matthew Mackenzie, Alex Fower, Alasdair J. Allan, Gemma F. Codner, Rosie K. Bunton-Stasyshyn, Lydia Teboul
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629895
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afbfcf2311037e778782e70023dbafb4
https://doi.org/10.1007/978-1-0716-2990-1_4
https://doi.org/10.1007/978-1-0716-2990-1_4
Autor:
Nicholas D Sanderson, John A. Hammond, Simon Gubbins, Shirley A. Ellis, Mark S. Gibson, Alasdair J. Allan, James Birch
Publikováno v:
The Journal of Immunology Author Choice
Key Points Two divergent allele lineages of KLRA have become fixed in the cattle population. The two cattle KLRA allele lineages likely have contrasting functions.
Cattle possess the most diverse repertoire of NK cell receptor genes among all ma
Cattle possess the most diverse repertoire of NK cell receptor genes among all ma
Autor:
Samanta Gasco, Gemma Atkins, Anny Devoy, David C. Thompson, Zeinab Ali, Michelle Simon, Elizabeth M. C. Fisher, Abraham Acevedo-Arozena, Alessandro Marrero-Gagliardi, Thomas J. Cunningham, Jackie Harrison, Edward O’Neill, José M. Brito-Armas, Alasdair J Allan, Michelle Stewart, Ross McLeod, Charlotte Tibbit, Gemma F. Codner, Francesca De Giorgio, Remya R. Nair, Silvia Corrochano, Lydia Teboul, Judith Noda, Georgia Price, Rosie K. A. Bunton-Stasyshyn
SUMMARYAmyotrophic lateral sclerosis - frontotemporal dementia spectrum disorder (ALS/FTD) is a complex neurodegenerative disease; up to 10% of cases are familial, usually arising from single dominant mutations in >30 causative genes. Transgenic mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dfa0375983fbaf85a49127de1182d75
https://doi.org/10.1101/2021.07.05.451113
https://doi.org/10.1101/2021.07.05.451113
Autor:
Alasdair J Allan, Marie Hutchison, Jorik Loeffler, Christou S, Sara Wells, Matthew Mackenzie, Michelle Stewart, Pike Fj, Adam Caulder, Malzer E, Lydia Teboul, Nicholas D Sanderson, Joffrey Mianné, McCabe Cv, Gemma F. Codner, Gates H
Recent developments in CRISPR/Cas9 genome editing tools have facilitated the introduction of more complex alleles, often spanning genetic intervals of several kilobases, directly into the embryo. These techniques often produce mosaic founder animals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1415a06720baeba395122bcfdf97d5bf
https://doi.org/10.1101/838193
https://doi.org/10.1101/838193
Autor:
Joe Harman, Peter J. McHugh, Lucas Greder, Dominic D G Owens, Vincent Frontera, Philip Hublitz, Marella F. T. R. de Bruijn, Lydia Teboul, Alasdair J Allan, Akin Bucakci, Adam Caulder, Gemma F. Codner
Publikováno v:
Nucleic Acids Research
The CRISPR system is widely used in genome editing for biomedical research. Here, using either dual paired Cas9D10A nickases or paired Cas9 nuclease we characterize unintended larger deletions at on-target sites that frequently evade common genotypin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dd16dfb3c903caac34c998df1bb403
https://doi.org/10.1093/nar/gkz459
https://doi.org/10.1093/nar/gkz459
Autor:
Lydia Teboul, Tahkur S. Babra, Stanley W. Botchway, Joan Gannon, Roger D. Cox, Viktoriya S Tsancheva, Louisa A K Zolkiewski, Rajesh Pandey, Xuan Xue, Alasdair J Allan, Alexander D. Graham, Alessia Candeo, Kamel Madi, Liz Bentley, Sam N. Olof
Publikováno v:
Biofabrication. 12:015018
Adipose models have been applied to mechanistic studies of metabolic diseases (such as diabetes) and the subsequent discovery of new therapeutics. However, typical models are either insufficiently complex (2D cell cultures) or expensive and labor int
Publikováno v:
The Journal of Immunology Author Choice
Primate and rodent NK cells form highly heterogeneous lymphocyte populations owing to the differential expression of germline-encoded receptors. Many of these receptors are polymorphic and recognize equally polymorphic determinants of MHC class I. Th