Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alasdair I MacDonald"'
Autor:
Alasdair I. MacDonald, Aron Baksh, Alexandria Holland, Heewhan Shin, Phoebe A. Rice, W. Marshall Stark, Femi J. Olorunniji
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Serine integrases are phage- (or mobile element-) encoded enzymes that catalyse site-specific recombination reactions between a short DNA sequence on the phage genome (attP) and a corresponding host genome sequence (attB), thereby integratin
Externí odkaz:
https://doaj.org/article/73b6640b58ef469a864e4d5cbc87a337
Autor:
Liane M McGlynn, Simon McCluney, Nigel B Jamieson, Jackie Thomson, Alasdair I MacDonald, Karin Oien, Euan J Dickson, C Ross Carter, Colin J McKay, Paul G Shiels
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131344 (2015)
The sirtuin gene family has been linked with tumourigenesis, in both a tumour promoter and suppressor capacity. Information regarding the function of sirtuins in pancreatic cancer is sparse and equivocal. We undertook a novel study investigating SIRT
Externí odkaz:
https://doaj.org/article/8273598e05554560a83e1781d238c0ff
Autor:
Harry Scott, Li Dong, Andrew Stevenson, Alasdair I. MacDonald, Sharmila Srinivasan, Paola Massimi, Lawrence Banks, Patricia E. Martin, Scott R. Johnstone, Sheila V. Graham
Publikováno v:
Journal of Cell Science.
Gap junction channels, composed of connexins, allow direct cell-to-cell communication. Connexin 43 (Cx43) is widely expressed in tissues, including the epidermis. In a previous study of human papillomavirus-positive cervical epithelial tumour cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d6a3ed5250f90cc03e93e729df23ea
https://doi.org/10.1242/jcs.259984
https://doi.org/10.1242/jcs.259984
Autor:
Sherwin P Montaño, Sally-J Rowland, James R Fuller, Mary E Burke, Alasdair I MacDonald, Martin R Boocock, W Marshall Stark, Phoebe A Rice
Publikováno v:
Nucleic acids research.
Site-specific DNA recombinases play a variety of biological roles, often related to the dissemination of antibiotic resistance, and are also useful synthetic biology tools. The simplest site-specific recombination systems will recombine any two cogna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a238aff985a0bf14f39d3d367d29b490
https://pubmed.ncbi.nlm.nih.gov/36100255
https://pubmed.ncbi.nlm.nih.gov/36100255
Publikováno v:
Journal of Virology. 89:5276-5287
High-risk human papillomaviruses (HR-HPV) cause anogenital cancers, including cervical cancer, and head and neck cancers. Human papillomavirus 16 (HPV16) is the most prevalent HR-HPV. HPV oncogenesis is driven by two viral oncoproteins, E6 and E7, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d78a37b1c834e7aa534cadae0ac355
https://doi.org/10.1128/jvi.03434-14
https://doi.org/10.1128/jvi.03434-14
Autor:
Christopher Martin, David R. S. Cumming, James Grant, Mohammed A. Al-Rawhani, Alasdair I. MacDonald, James Beeley, Gordon Campbell, Luiz Carlos Paiva Gouveia, Michael P. Barrett, Chunxiao Hu, Boon Chong Cheah
Elevated cholesterol levels are associated with a greater risk of developing cardiovascular disease and other illnesses, making it a prime candidate for detection on a disposable biosensor for rapid point of care diagnostics. One of the methods to qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a443aa33835197ae339ec75d13b3f603
https://eprints.gla.ac.uk/131307/1/131307.pdf
https://eprints.gla.ac.uk/131307/1/131307.pdf
We have demonstrated a chip-based diagnostics tool for the quantification of metabolites, using specific enzymes, to study enzyme kinetics and calculate the Michaelis-Menten constant. An array of 256×256 ion-sensitive field effect transistors (ISFET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327351a1369d31016614114074db088
https://eprints.gla.ac.uk/144234/1/144234.pdf
https://eprints.gla.ac.uk/144234/1/144234.pdf
Autor:
Anthony P. Payne, Alasdair I. MacDonald, Donald C. McMillan, Zahra M.A. Mohammed, Joanne Edwards, Justice E. Reilly, Liane M. McGlynn, Jennifer Curle, S. Zino, Paul G. Shiels, Elizabeth Mallon
Publikováno v:
European Journal of Cancer. 50:290-301
Purpose Sirtuins comprise a family of genes involved in cellular stress, survival and damage responses. They have been implicated in a range of diseases including cancer, with most information pertaining to their function in tumourigenesis being deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a912b6f79f9a965bb1da27b7124bd2
https://doi.org/10.1016/j.ejca.2013.10.005
https://doi.org/10.1016/j.ejca.2013.10.005
Autor:
Arfon Powell, Paul G. Shiels, Liane M. McGlynn, Paul G. Horgan, Alasdair I. MacDonald, Campbell S.D. Roxburgh, Joanne Edwards, Donald C. McMillan, Colin H. Richards
Publikováno v:
British Journal of Cancer
Background: Immune cell infiltrates are important determinants of colorectal cancer (CRC) outcome. Their presence may be driven by tumour or host-specific factors. From previous studies in mice, senescence, a state of cell cycle arrest, may moderate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fa9fa46e35b58508df89c121faa3c6
http://europepmc.org/articles/PMC3798960
http://europepmc.org/articles/PMC3798960
Autor:
Christian Koppelstaetter, Alan MacIntyre, David Russell, Liane M. McGlynn, R. W. Davies, Paul G. Shiels, Kathrin Eller, Alasdair I. MacDonald
Publikováno v:
Rejuvenation Research. 16:11-20
Pathfinder cells (PCs) are a novel class of adult-derived cells that facilitate functional repair of host tissue. We used rat PCs to demonstrate that they enable the functional mitigation of ischemia reperfusion (I/R) injury in a mouse model of renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1e14c7c878863a64639d6f125d41b7
https://doi.org/10.1089/rej.2012.1350
https://doi.org/10.1089/rej.2012.1350