Zobrazeno 1 - 10
of 346
pro vyhledávání: '"Alasdair C, Steven"'
Autor:
Updesh Dixit, Savita Bhutoria, Xuhong Wu, Liming Qiu, Menachem Spira, Sheeba Mathew, Richard Harris, Lucas J. Adams, Sean Cahill, Rajiv Pathak, P. Rajesh Kumar, Minh Nguyen, Seetharama A. Acharya, Michael Brenowitz, Steven C. Almo, Xiaoqin Zou, Alasdair C. Steven, David Cowburn, Mark Girvin, Ganjam V. Kalpana
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and su
Externí odkaz:
https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d
Autor:
Michael H. C. Buch, William W. Newcomb, Dennis C. Winkler, Alasdair C. Steven, J. Bernard Heymann
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Herpes simplex virus 1 (HSV-1) infects a majority of humans, causing mostly mild disease but in some cases progressing toward life-threatening encephalitis. Understanding the life cycle of the virus is important to devise countermeasures.
Externí odkaz:
https://doaj.org/article/aa34227f2ac04187ad79ecd6912d312f
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007782 (2020)
Hepatitis B virus (HBV) is a leading cause of liver disease. The capsid is an essential component of the virion and it is therefore of interest how it assembles and disassembles. The capsid protein is unusual both for its rare fold and that it polyme
Externí odkaz:
https://doaj.org/article/4a3e1b56e670415f8e8467ee41c7a1da
Publikováno v:
eLife, Vol 9 (2020)
The portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packaging. Twelve subunits of the portal protein define a tunnel, through which DNA is translocated into the capsid. It is unknown how the
Externí odkaz:
https://doaj.org/article/6a8dc92bf5d44e89be37a2f03d2a0db0
Autor:
Rommie E. Amaro, Pek U Ieong, Gary Huber, Abigail Dommer, Alasdair C. Steven, Robin M. Bush, Jacob D. Durrant, Lane W. Votapka
Publikováno v:
ACS Central Science, Vol 4, Iss 11, Pp 1570-1577 (2018)
Externí odkaz:
https://doaj.org/article/fc06bd50c75b4f429bfae9d13556a2dd
Publikováno v:
Viruses, Vol 12, Iss 11, p 1282 (2020)
The virions of tailed bacteriophages and the evolutionarily related herpesviruses contain, in addition to highly condensed DNA, substantial quantities of internal proteins. These proteins (“ejection proteins”) have roles in scaffolding, maturatio
Externí odkaz:
https://doaj.org/article/0a58204a94bd4054886df1fc9369bc1c
Autor:
J. Bernard Heymann, Bing Wang, William W. Newcomb, Weimin Wu, Dennis C. Winkler, Naiqian Cheng, Erin R. Reilly, Ru-Ching Hsia, Julie A. Thomas, Alasdair C. Steven
Publikováno v:
Viruses, Vol 12, Iss 9, p 910 (2020)
“Giant” phages have genomes of >200 kbp, confined in correspondingly large capsids whose assembly and maturation are still poorly understood. Nevertheless, the first assembly product is likely to be, as in other tailed phages, a procapsid that su
Externí odkaz:
https://doaj.org/article/aee88b338a3a43249a7e73bbcc099c23
Autor:
Mariia Novikova, Lucas J. Adams, Juan Fontana, Anna T. Gres, Muthukumar Balasubramaniam, Dennis C. Winkler, Sagar B. Kudchodkar, Ferri Soheilian, Stefan G. Sarafianos, Alasdair C. Steven, Eric O. Freed
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Late in the HIV-1 replication cycle, the viral structural protein Gag is targeted to virus assembly sites at the plasma membrane of infected cells. The capsid (CA) domain of Gag plays a critical role in the formation of the hexameric Gag lat
Externí odkaz:
https://doaj.org/article/d1bc164630d541f6abb520b9b82a3d58
Autor:
William W. Newcomb, Juan Fontana, Dennis C. Winkler, Naiqian Cheng, J. Bernard Heymann, Alasdair C. Steven
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Many viruses migrate between different cellular compartments for successive stages of assembly. The HSV-1 capsid assembles in the nucleus and then transfers into the cytoplasm. First, the capsid buds through the inner nuclear membrane, becom
Externí odkaz:
https://doaj.org/article/d721955c8359428484177c7422185897
Autor:
Weimin Wu, Justin C. Leavitt, Naiqian Cheng, Eddie B. Gilcrease, Tina Motwani, Carolyn M. Teschke, Sherwood R. Casjens, Alasdair C. Steven
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT The P22 capsid is a T=7 icosahedrally symmetric protein shell with a portal protein dodecamer at one 5-fold vertex. Extending outwards from that vertex is a short tail, and putatively extending inwards is a 15-nm-long α-helical barrel forme
Externí odkaz:
https://doaj.org/article/9b9b267307a1486f8926e69d4dbbe79f