Antitumor activity and targeting p53-PUMA mRNA expression by 5-flurouracil PLGA-lipid polymeric nanoparticles in mouse mammary carcinomas: comparison to free 5-flurouracil.

Autor: Alsharif ST; PharmD program, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia., Gardouh AM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jadara University, Irbid, Jordan., Mandour MF; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Alaqais ZM; PharmD program, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia., Alharbi LK; PharmD program, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia., Almarwani MJ; PharmD program, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia., Mokhtar HI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University-Kantara Branch, Ismailia, Egypt., Hisham FA; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Abdellah MM; Department of Pathology, Faculty of Medicine, Galala University, Suez, Egypt.; Department of Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Mohamed GM; Nutrition and Food Science Department, College of Home Economics, Tabuk University, Tabuk, Saudi Arabia., Shorog EM; Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Almaeen AH; Pathology Department, College of Medicine, Jouf University, Jouf, Saudi Arabia., Atteia HH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.; Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., Zaitone SA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Publikováno v: Toxicology mechanisms and methods [Toxicol Mech Methods] 2024 May; Vol. 34 (4), pp. 385-397. Date of Electronic Publication: 2024 Jan 08.