Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Alano Martins Pedrosa"'
1
Akademický článek
Effects of hydroxyurea on cytotoxicity, inflammation and oxidative stress markers in neutrophils of patients with sickle cell anemia: dose-effect relationship
Autor: Alano Martins Pedrosa, Luzia Kalyne A.M. Leal, Romélia Pinheiro G. Lemes
Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 468-475 (2021)
Introduction: Although the efficacy of hydroxyurea (HU) in inhibiting erythrocyte sickling has been well demonstrated, the action of this drug on human neutrophils and the mechanism by which it improves the manifestations of the disease have not been
Externí odkaz: https://doaj.org/article/c923064b0797471aa27a538ff3a97fb9
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2
Akademický článek
Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea
Autor: Alano Martins Pedrosa, Maritza Cavalcante Barbosa, Thayna Nogueira dos Santos, Luzia Kalyne Almeida Moreira Leal, Amanda de Araújo Lopes, Darcielle Bruna Dias Elias, Greyce Luri Sasahara, Bruno Coêlho Cavalcanti, Romélia Pinheiro Gonçalves
Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 50, Iss 2, Pp 401-410 (2014)
Hydroxyurea (HU) is the most important advance in the treatment of sickle cell anaemia (SCA) for preventing complications and improving quality of life for patients. However, some aspects of treatment with HU remain unclear, including their effect on
Externí odkaz: https://doaj.org/article/93067a93b42b4d74bbf1ae6e7f75b148
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3
Akademický článek
Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline
Autor: Darcielle Bruna Dias Elias, Lilianne Brito da Silva Rocha, Maritza Barbosa Cavalcante, Alano Martins Pedrosa, Izabel Cristina Bandeira Justino, Romélia Pinheiro Gonçalves
Publikováno v: Revista Brasileira de Hematologia e Hemoterapia, Vol 34, Iss 4, Pp 265-269 (2012)
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. OBJECTIVE: To evaluate the correlation
Externí odkaz: https://doaj.org/article/de4509db93124522bd8682ffcf3ddb15
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4
Dissertation/ Thesis
Study cytotoxicity, inflammation and oxidative stress in neutrophils of patients with sickle cell disease: the influence treatment with hydroxyurea
Autor: Alano Martins Pedrosa
Publikováno v: Biblioteca Digital de Teses e Dissertações da UFCUniversidade Federal do CearáUFC.
CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
Falciform Anemia (FA) is a hereditary hemoglobinopathy resulting from a β-globin gene mutation (α2β26 GLU→ VAL) that originates a hemoglobin variant called S (HbS). Its polymer
Externí odkaz: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9331
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5
Effects of hydroxyurea on cytotoxicity, inflammation and oxidative stress markers in neutrophils of patients with sickle cell anemia: dose-effect relationship
Autor: Romélia Pinheiro Gonçalves Lemes, Luzia Kalyne Almeida Moreira Leal, Alano Martins Pedrosa
Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 468-475 (2021)
Hematology, Transfusion and Cell Therapy
Hematology, Transfusion and Cell Therapy, Volume: 43, Issue: 4, Pages: 468-475, Published: 29 NOV 2021
Introduction: Although the efficacy of hydroxyurea (HU) in inhibiting erythrocyte sickling has been well demonstrated, the action of this drug on human neutrophils and the mechanism by which it improves the manifestations of the disease have not been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5eadebd89ea53b6a6a4167044df85e3
http://www.sciencedirect.com/science/article/pii/S2531137920302820
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6
Gene expression of HIF‐1α and VEGF in response to hypoxia in sickle cell anaemia: Influence of hydroxycarbamide
Autor: Alano Martins Pedrosa, Romélia Pinheiro Gonçalves Lemes
Publikováno v: British Journal of Haematology. 190
Hypoxia and hemoglobin S polymerization are two triggers responsible for initiating erythrocyte sickling and the consequent clinical sickle cell anemia (SCA) events. The objective of this study was to investigate the expression of hypoxia-responsive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876bfb455432baf6d7a09049049e5398
https://doi.org/10.1111/bjh.16693
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7
The Effect of a Selective Inhibitor of Phosphodiesterase-9 on Oxidative Stress, Inflammation and Cytotoxicity in Neutrophils from Patients with Sickle Cell Anaemia
Autor: Romélia Pinheiro Gonçalves Lemes, Thayna Nogueira dos Santos, Luzia Kalyne Almeida Moreira Leal, Greyce Luri Sasahara, Talyta Ellen de Jesus dos Santos, Amanda de Araújo Lopes, Darcielle Bruna Dias Elias, Maritza Cavalcante Barbosa, Alano Martins Pedrosa
Publikováno v: Basic & Clinical Pharmacology & Toxicology. 118:271-278
The aim of the study was to investigate the possible anti-inflammatory and antioxidant effects of BAY 73-6691 on neutrophils from SCA patients. This study included 35 patients with a molecular diagnosis of SCA, whose neutrophils were isolated and tre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99438b0f593fef49feb2768bb5ee04cc
https://doi.org/10.1111/bcpt.12487
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9
Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea
Autor: Darcielle Bruna Dias Elias, Maritza Cavalcante Barbosa, Amanda de Araújo Lopes, Greyce Luri Sasahara, Bruno C. Cavalcanti, Alano Martins Pedrosa, Luzia Kalyne Almeida Moreira Leal, Romélia Pinheiro Gonçalves, Thayna Nogueira dos Santos
Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Volume: 50, Issue: 2, Pages: 401-410, Published: APR 2014
Brazilian Journal of Pharmaceutical Sciences; Vol. 50 No. 2 (2014); 401-410
Brazilian Journal of Pharmaceutical Sciences; Vol. 50 Núm. 2 (2014); 401-410
Brazilian Journal of Pharmaceutical Sciences; v. 50 n. 2 (2014); 401-410
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Vol 50, Iss 2, Pp 401-410 (2014)
Hydroxyurea (HU) is the most important advance in the treatment of sickle cell anaemia (SCA) for preventing complications and improving quality of life for patients. However, some aspects of treatment with HU remain unclear, including their effect on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274bb1c4bf9dfb40da222e77ff19e41b
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200401&lng=en&tlng=en
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10
Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline
Autor: Romélia Pinheiro Gonçalves, Darcielle Bruna Dias Elias, Maritza Barbosa Cavalcante, Izabel Cristina Bandeira Justino, Lilianne Brito da Silva Rocha, Alano Martins Pedrosa
Publikováno v: Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC
Revista Brasileira de Hematologia e Hemoterapia, Vol 34, Iss 4, Pp 265-269 (2012)
Revista Brasileira de Hematologia e Hemoterapia
Revista Brasileira de Hematologia e Hemoterapia v.34 n.4 2012
Revista brasileira de hematologia e hemoterapia
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
Revista Brasileira de Hematologia e Hemoterapia, Volume: 34, Issue: 4, Pages: 265-269, Published: 2012
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. OBJECTIVE: To evaluate the correlation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bf3f50c1daedb0dc157ea0f111978e
http://www.repositorio.ufc.br/handle/riufc/5786
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