Effects of hydroxyurea on cytotoxicity, inflammation and oxidative stress markers in neutrophils of patients with sickle cell anemia: dose-effect relationship

Autor: Alano Martins Pedrosa, Luzia Kalyne A.M. Leal, Romélia Pinheiro G. Lemes

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 468-475 (2021)

Introduction: Although the efficacy of hydroxyurea (HU) in inhibiting erythrocyte sickling has been well demonstrated, the action of this drug on human neutrophils and the mechanism by which it improves the manifestations of the disease have not been

Externí odkaz: https://doaj.org/article/c923064b0797471aa27a538ff3a97fb9

Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea

Autor: Alano Martins Pedrosa, Maritza Cavalcante Barbosa, Thayna Nogueira dos Santos, Luzia Kalyne Almeida Moreira Leal, Amanda de Araújo Lopes, Darcielle Bruna Dias Elias, Greyce Luri Sasahara, Bruno Coêlho Cavalcanti, Romélia Pinheiro Gonçalves

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 50, Iss 2, Pp 401-410 (2014)

Hydroxyurea (HU) is the most important advance in the treatment of sickle cell anaemia (SCA) for preventing complications and improving quality of life for patients. However, some aspects of treatment with HU remain unclear, including their effect on

Externí odkaz: https://doaj.org/article/93067a93b42b4d74bbf1ae6e7f75b148

Study cytotoxicity, inflammation and oxidative stress in neutrophils of patients with sickle cell disease: the influence treatment with hydroxyurea

Autor: Alano Martins Pedrosa

Publikováno v: Biblioteca Digital de Teses e Dissertações da UFCUniversidade Federal do CearáUFC.

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
Falciform Anemia (FA) is a hereditary hemoglobinopathy resulting from a β-globin gene mutation (α2β26 GLU→ VAL) that originates a hemoglobin variant called S (HbS). Its polymer

Externí odkaz: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9331

Variables Leading to Usage of Alteplase Versus Heparin Lock in Patients With Tunneled Catheters in Hemodialysis Care Project Centers, Saudi Arabia.

Autor: Alhammouri J; Hemodialysis Care Project, Ministry of National Guard Health Affairs, Riyadh, SAU.; Research Office, King Abdullah International Medical Research Center, Riyadh, SAU.; Research Office, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU., Ockhuis D; Hemodialysis Care Project, Ministry of National Guard Health Affairs, Riyadh, SAU., Hibionada E; Hemodialysis Care Project, Ministry of National Guard Health Affairs, Riyadh, SAU., Albalawi M; Biostatistics, King Abdullah International Medical Research Center, Riyadh, SAU., Alnahdi R; Hemodialysis Care Project, Ministry of National Guard Health Affairs, Jeddah, SAU., Hikal B; Hemodialysis Care Project, Ministry of National Guard Health Affairs, Madinah, SAU., Koko E; Hemodialysis Care Project, Ministry of National Guard Health Affairs, Makkah, SAU., Alano MML; Hemodialysis Care Project, Ministry of National Guard Health Affairs, Hail, SAU., Troncoso M; Hemodialysis Care Project, Ministry of National Guard Health Affairs, Riyadh, SAU., Hashmi MN; Nephrology, Ministry of National Guard Health Affairs, Jeddah, SAU.

Publikováno v: Cureus [Cureus] 2024 May 21; Vol. 16 (5), pp. e60817. Date of Electronic Publication: 2024 May 21 (Print Publication: 2024).

Occurrence of polycyclic aromatic hydrocarbons throughout the processing stages of erva-mate (Ilex paraguariensis).

Autor: Vieira MA; Department of Food Science and Technology, Federal University of Santa Catarina, 88034-001 Florianopolis, SC, Brazil., Maraschin M, Rovaris AA, Amboni RD, Pagliosa CM, Xavier JJ, Amante ER

Publikováno v: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2010 Jun; Vol. 27 (6), pp. 776-82.