Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Alanna M. Ritchie"'
Autor:
Gregory P. Owens, Timothy J. Fellin, Adeline Matschulat, Vanessa Salas, Kristin L. Schaller, Katherine S. Given, Alanna M. Ritchie, Andre Navarro, Kevin Blauth, Ethan G. Hughes, Wendy B. Macklin, Jeffrey L. Bennett
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
B cell clonal expansion and cerebrospinal fluid (CSF) oligoclonal IgG bands are established features of the immune response in multiple sclerosis (MS). Clone-specific recombinant monoclonal IgG1 Abs (rAbs) derived from MS patient CSF plasmablasts bou
Externí odkaz:
https://doaj.org/article/5c9b85e85c2341ef917d380b1f3354df
Autor:
Alanna M. Ritchie, Gregory P. Owens, Gildas Lepennetier, Markus C. Kowarik, Jeffrey Bennett, D Astling, Bernhard Hemmer
Publikováno v:
Neurotherapeutics
Natalizumab and fingolimod are effective multiple sclerosis (MS) therapies that disrupt lymphocyte migration but have differential effects on B cell maturation and trafficking. We investigated their effects on peripheral blood (PB) and cerebrospinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986d2905912da1a74943c5c06ff708cf
https://pubmed.ncbi.nlm.nih.gov/33258072
https://pubmed.ncbi.nlm.nih.gov/33258072
Autor:
Hannah Schumann, Bernhard Hemmer, Gregory P. Owens, Markus C. Kowarik, Christiane Gasperi, Alanna M. Ritchie, Scott Wemlinger, Monika Dzieciatkowska, Jeffrey Bennett, David P. Astling
Publikováno v:
Annals of Clinical and Translational Neurology
Objectives Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory disorder of the central nervous system (CNS) targeted against aquaporin-4 (AQP4). The origin and trafficking of AQP4-specific B cells in NMOSD remains unknown. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3701060e4be4cba64f4a9a15ad00c24d
https://doi.org/10.1002/acn3.418
https://doi.org/10.1002/acn3.418
Autor:
John Soltys, Panos Stathopoulos, Elizabeth Cotzomi, Alanna M. Ritchie, Jeffrey Bennett, Eric Meffre, Fabien R. Delmotte, Jason A. Vander Heiden, Ruoyi Jiang, Tyler Oe, Michael J. Levy, Joel Sng, Casey S. Lee, Anthony K Ma, Kevin C. O’Connor, Steven H. Kleinstein
Publikováno v:
Brain
Neuromyelitis optica spectrum disorders (NMOSD) constitute rare autoimmune disorders of the CNS that are primarily characterized by severe inflammation of the spinal cord and optic nerve. Approximately 75% of NMOSD patients harbour circulating pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d12d661cd483a956a1c4fd5e481650f
https://pubmed.ncbi.nlm.nih.gov/31056665
https://pubmed.ncbi.nlm.nih.gov/31056665
Autor:
Jeffrey Bennett, Kevin Blauth, Cory R. Reiter, Adeline M. Matschulat, Alanna M. Ritchie, Nicholas L. Baird, Gregory P. Owens, John Soltys
Publikováno v:
Acta Neuropathologica. 130:765-781
B cells are implicated in the etiology of multiple sclerosis (MS). Intrathecal IgG synthesis, cerebrospinal fluid (CSF) oligoclonal bands and lesional IgG deposition suggest a role for antibody-mediated pathology. We examined the binding of IgG1 mono
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a49708fb769ffec2cca7ffb5fa0e93
https://doi.org/10.1007/s00401-015-1500-6
https://doi.org/10.1007/s00401-015-1500-6
Autor:
S. Gattenlöhner, S.A. Sargsyan, Donald H. Gilden, Bernhard Hemmer, Alanna M. Ritchie, Jeffrey Bennett, Christine Stadelmann, Mark P. Burgoon, S. Anderson, Andrew J. Shearer, Gregory P. Owens
Publikováno v:
Neurology. 74:1127-1135
Objective: Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that becomes latent in B-lymphocytes and has been implicated in the pathogenesis of multiple sclerosis (MS). We searched for latent and active EBV infection in MS brain and CSF. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d54a607903b0755a044a7cf629fb23aa
https://doi.org/10.1212/wnl.0b013e3181d865a1
https://doi.org/10.1212/wnl.0b013e3181d865a1
Autor:
Alanna M. Ritchie, Kevin C. O’Connor, Gregory P. Owens, Xiaoli Yu, David A. Hafler, Andrew J. Shearer, Donald H. Gilden, R. Anthony Williamson, Chiwah Lam, Jeffrey Bennett, Hans Lassmann, Mark P. Burgoon, Marius Birlea, Cecily Dupree
Publikováno v:
Annals of Neurology. 65:639-649
Objective Intrathecal IgG synthesis, persistence of bands of oligoclonal IgG, and memory B-cell clonal expansion are well-characterized features of the humoral response in multiple sclerosis (MS). Nevertheless, the target antigen of this response rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabfd57fedbeb8192653fd1e71929815
https://doi.org/10.1002/ana.21641
https://doi.org/10.1002/ana.21641
Autor:
Gregory P. Owens, Donald H. Gilden, Jeffrey Bennett, Sabine Cepok, Alanna M. Ritchie, Randall J. Cohrs, Sarah W. Anderson, Bernhard Hemmer, Mark P. Burgoon
Publikováno v:
Annals of Neurology. 65:474-479
Herpesvirions and varicella zoster virus (VZV) DNA were recently reported in all 15 cerebrospinal fluid (CSF) samples from patients with relapsing-remitting multiple sclerosis (MS) obtained within 1 week of exacerbation. Using identical electron micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2eafeb6a5221a395674fa1c2495bccd
https://doi.org/10.1002/ana.21605
https://doi.org/10.1002/ana.21605
Autor:
Alanna M. Ritchie, Sydni J. Edwards, Kurt Haubold, Jeffrey Bennett, Gregory P. Owens, Andrew J. Shearer, Donald H. Gilden, Mark P. Burgoon
Publikováno v:
Journal of Neuroimmunology. 199:126-132
Using FACS and single cell reverse transcriptase polymerase chain reaction, we examined the cerebrospinal fluid (CSF) IgG VH repertoires from 10 subjects with a clinically isolated demyelinating syndrome (CIS). B and plasma cell repertoires from indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b530f455d2a51dca79daa418fa9cd86f
https://doi.org/10.1016/j.jneuroim.2008.04.031
https://doi.org/10.1016/j.jneuroim.2008.04.031
Autor:
Donald H. Gilden, Alanna M. Ritchie, Mark P. Burgoon, Jeffrey Bennett, Gregory P. Owens, D. Becker
Publikováno v:
Neurology. 68:1815-1819
Objective: To demonstrate the specificity of expanded CD138 + plasma cell clones recovered from the CSF of a patient with subacute sclerosing panencephalitis (SSPE) for measles virus (MV). Methods: IgG variable region sequences of single-antibody-sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7e745c7968d566da30fb6681bc6906
https://doi.org/10.1212/01.wnl.0000262036.56594.7c
https://doi.org/10.1212/01.wnl.0000262036.56594.7c