Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Alanna G Spiteri"'
Autor:
Yihan Wang, Shu Liu, Alanna G. Spiteri, Andrew Liem Hieu Huynh, Chenyin Chu, Colin L. Masters, Benjamin Goudey, Yijun Pan, Liang Jin
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Several (inter)national longitudinal dementia observational datasets encompassing demographic information, neuroimaging, biomarkers, neuropsychological evaluations, and muti-omics data, have ushered in a new era of potential for integrating
Externí odkaz:
https://doaj.org/article/eefdc1e7f56e408da1410a2f95024c8a
Autor:
Alanna G. Spiteri, Claire L. Wishart, Duan Ni, Barney Viengkhou, Laurence Macia, Markus J. Hofer, Nicholas J. C. King
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-27 (2023)
Abstract As the resident parenchymal myeloid population in the central nervous system (CNS), microglia are strategically positioned to respond to neurotropic virus invasion and have been implicated in promoting both disease resolution and progression
Externí odkaz:
https://doaj.org/article/7a43bb50ad4e4929b9aa65ff14a72977
Autor:
Alanna G. Spiteri, Tamara Suprunenko, Erin Cutts, Andrew Suen, Thomas M. Ashhurst, Barney Viengkhou, Nicholas J. C. King, Markus J. Hofer
Publikováno v:
Viruses, Vol 16, Iss 3, p 390 (2024)
CD8+ T cells are critical to the adaptive immune response against viral pathogens. However, overwhelming antigen exposure can result in their exhaustion, characterised by reduced effector function, failure to clear virus, and the upregulation of inhi
Externí odkaz:
https://doaj.org/article/26022dd0865c4e828fc5dc8f2712d9fb
Autor:
Gi Uk Jeong, Hyung-Jun Kwon, Wern Hann Ng, Xiang Liu, Hyun Woo Moon, Gun Young Yoon, Hye Jin Shin, In-Chul Lee, Zheng Lung Ling, Alanna G. Spiteri, Nicholas J. C. King, Adam Taylor, Ji Soo Chae, Chonsaeng Kim, Dae-Gyun Ahn, Kyun-Do Kim, Young Bae Ryu, Seong-Jun Kim, Suresh Mahalingam, Young-Chan Kwon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
SARS-CoV-2 pathogenesis is very complex and not fully understood yet. Here, Jeong et al. show that intranasally infected K18-hACE2 transgenic mice develop ocular infection and retinal inflammation, while intratracheal infection results in the dissemi
Externí odkaz:
https://doaj.org/article/29d46674b74e4d01a917d241c0278701
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Bone marrow (BM)-derived monocytes induce inflammation and tissue damage in a range of pathologies. In particular, in a mouse model of West Nile virus (WNV) encephalitis (WNE), nitric oxide-producing, Ly6Chi inflammatory monocytes from the BM are rec
Externí odkaz:
https://doaj.org/article/aa0789a46c3844e7b056c7f8842c7136
Autor:
Alanna G. Spiteri, Rachel L. Terry, Claire L. Wishart, Thomas M. Ashhurst, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-24 (2021)
Abstract Background Differentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a ‘microglia-like’ phenot
Externí odkaz:
https://doaj.org/article/ebf58f4e1d3f4998b8f08e4ddf92213b
Autor:
Alanna G Spiteri, Nicholas J.C. King
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 6, Pp 1269-1270 (2023)
Externí odkaz:
https://doaj.org/article/a9f660f2fc7547a3a15f77a842e49842
Autor:
Alanna G. Spiteri, Duan Ni, Zheng Lung Ling, Laurence Macia, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate the biology of this central nervous system (CNS)-resident myeloid population, but the indirect or off-target effects of this agent remain largely unexplored. In
Externí odkaz:
https://doaj.org/article/5d28240282434c559993a2f7d3c82cd6
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Inflammation of the brain parenchyma is characteristic of neurodegenerative, autoimmune, and neuroinflammatory diseases. During this process, microglia, which populate the embryonic brain and become a permanent sentinel myeloid population, are inexor
Externí odkaz:
https://doaj.org/article/df4f89a719764b5084e4893742bd6db5
Autor:
Jonathan D. Teo, Oana C. Marian, Alanna G. Spiteri, Madeline Nicholson, Huitong Song, Jasmine X. Y. Khor, Holly P. McEwen, Anjie Ge, Monokesh K. Sen, Laura Piccio, Jessica L. Fletcher, Nicholas J. C. King, Simon S. Murray, Jens C. Brüning, Anthony S. Don
Publikováno v:
GliaREFERENCES.
The sphingolipids galactosylceramide (GalCer), sulfatide (ST) and sphingomyelin (SM) are essential for myelin stability and function. GalCer and ST are synthesized mostly from C22-C24 ceramides, generated by Ceramide Synthase 2 (CerS2). To clarify th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd0aa8eae28e42f1e57fd6b417fb276
https://pubmed.ncbi.nlm.nih.gov/36583573
https://pubmed.ncbi.nlm.nih.gov/36583573