A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates

Autor: Douglas, AD, Baldeviano, J, Jin, J, Silk, SE, Marshall, JM, Alanine, DGW, Wang, C, Edwards, NJ, Draper, SJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::fa18f4f2f0793161ef9731c7572cb946
https://doi.org/10.1038/s41467-019-09894-4

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex.

Autor: Williams BG; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., King LDW; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Pulido D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Quinkert D; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Lias AM; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Silk SE; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Ragotte RJ; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Davies H; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Barrett JR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., McHugh K; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Rigby CA; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK., Alanine DGW; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Barfod L; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Shea MW; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Cowley LA; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Dabbs RA; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Pattinson DJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Douglas AD; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Lyth OR; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Illingworth JJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Jin J; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Carnrot C; Novavax AB, Kungsgatan 109, SE-753 18, Uppsala, Sweden., Kotraiah V; Leidos Life Sciences, Frederick, MD, USA., Christen JM; Leidos Life Sciences, Frederick, MD, USA., Noe AR; Leidos Life Sciences, Frederick, MD, USA.; Latham BioPharm Group, Elkridge, MD, USA., MacGill RS; Center for Vaccine Innovation and Access, PATH, Washington, DC, USA., King CR; Center for Vaccine Innovation and Access, PATH, Washington, DC, USA., Birkett AJ; Center for Vaccine Innovation and Access, PATH, Washington, DC, USA., Soisson LA; USAID, 1300 Pennsylvania Ave. NW, Washington, DC, USA., Skinner K; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK., Miura K; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD, USA., Long CA; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD, USA., Higgins MK; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK., Draper SJ; Department of Biochemistry, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford, UK. simon.draper@bioch.ox.ac.uk.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford, UK. simon.draper@bioch.ox.ac.uk.; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, UK. simon.draper@bioch.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. simon.draper@bioch.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 07; Vol. 15 (1), pp. 4857. Date of Electronic Publication: 2024 Jun 07.

Antibodies from malaria-exposed Malians generally interact additively or synergistically with human vaccine-induced RH5 antibodies.

Autor: Willcox AC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Huber AS; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Diouf A; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Barrett JR; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom., Silk SE; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom., Pulido D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom., King LDW; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom., Alanine DGW; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom., Minassian AM; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom., Diakite M; Malaria Research and Training Center, Faculty of Medicine, Pharmacy, and Odontostomatology, University of Sciences, Techniques, and Technologies of Bamako, Bamako 1805, Mali., Draper SJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom., Long CA; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Miura K; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2021 Jun 21; Vol. 2 (7), pp. 100326. Date of Electronic Publication: 2021 Jun 21 (Print Publication: 2021).

Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody.

Autor: Rawlinson TA; Jenner Institute, University of Oxford, Oxford, UK., Barber NM; Department of Biochemistry, University of Oxford, Oxford, UK., Mohring F; Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Cho JS; Jenner Institute, University of Oxford, Oxford, UK., Kosaisavee V; Faculty of Public Health, Mahidol University, Bangkok, Thailand., Gérard SF; Department of Biochemistry, University of Oxford, Oxford, UK., Alanine DGW; Jenner Institute, University of Oxford, Oxford, UK., Labbé GM; Jenner Institute, University of Oxford, Oxford, UK., Elias SC; Jenner Institute, University of Oxford, Oxford, UK., Silk SE; Jenner Institute, University of Oxford, Oxford, UK., Quinkert D; Jenner Institute, University of Oxford, Oxford, UK., Jin J; Jenner Institute, University of Oxford, Oxford, UK., Marshall JM; Jenner Institute, University of Oxford, Oxford, UK., Payne RO; Jenner Institute, University of Oxford, Oxford, UK., Minassian AM; Jenner Institute, University of Oxford, Oxford, UK., Russell B; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Rénia L; Singapore Immunology Network, A*STAR, Singapore, Singapore., Nosten FH; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Moon RW; Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Higgins MK; Department of Biochemistry, University of Oxford, Oxford, UK. matthew.higgins@bioch.ox.ac.uk., Draper SJ; Jenner Institute, University of Oxford, Oxford, UK. simon.draper@ndm.ox.ac.uk.

Publikováno v: Nature microbiology [Nat Microbiol] 2019 Sep; Vol. 4 (9), pp. 1497-1507. Date of Electronic Publication: 2019 May 27.

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.

Autor: Alanine DGW; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Quinkert D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Kumarasingha R; Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia., Mehmood S; Department of Chemistry, University of Oxford, Oxford OX1 3QZ, UK., Donnellan FR; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Minkah NK; Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave. N., #500, Seattle, WA 98109, USA., Dadonaite B; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Diouf A; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Galaway F; Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Silk SE; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Jamwal A; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Marshall JM; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Miura K; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Foquet L; Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave. N., #500, Seattle, WA 98109, USA., Elias SC; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Labbé GM; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Douglas AD; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Jin J; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Payne RO; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Illingworth JJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Pattinson DJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Pulido D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., Williams BG; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK., de Jongh WA; ExpreS(2)ion Biotechnologies, SCION-DTU Science Park, Agern Allé 1, Hørsholm 2970, Denmark., Wright GJ; Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK., Kappe SHI; Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Ave. N., #500, Seattle, WA 98109, USA., Robinson CV; Department of Chemistry, University of Oxford, Oxford OX1 3QZ, UK., Long CA; Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA., Crabb BS; Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia., Gilson PR; Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia., Higgins MK; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address: matthew.higgins@bioch.ox.ac.uk., Draper SJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address: simon.draper@ndm.ox.ac.uk.

Publikováno v: Cell [Cell] 2019 Jun 27; Vol. 178 (1), pp. 216-228.e21. Date of Electronic Publication: 2019 Jun 13.