Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways

Autor: Zaid H. Maayah, Alshamsan A, Al Anazi Fe, Osamah M Belali, Alanazi Io, Abdulaziz M.S. Alsaad, Hesham M. Korashy, Al-Atawi Fo

Publikováno v: Anticancer research. 37(9)

The tyrosine kinase inhibitor sunitinib was recently approved for use against gastrointestinal stromal tumors and advanced renal cell carcinoma. Yet, the protective effect of sunitinib against breast cancer has been poorly investigated. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04aab0183b298251e72a95c2957eacb5
https://pubmed.ncbi.nlm.nih.gov/28870911

Plasma-based proteomic profiling identifies the distinct regulation of proteins in hyperplasia and endometrial cancer.

Autor: Akkour K; Obstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia., Alanazi IO; Healthy Aging Research Institute, King Abdulaziz City for Science and Technology (KACST), Health Sector, Riyadh, 11442, Saudi Arabia., Alfadda AA; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia.; Department of Medicine, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia., Masood A; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia., Alhalal H; Obstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia., Joy SS; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia.; Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia., Bassi A; Obstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia., Alshehri E; Obstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia., Alwehaibi MA; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia., Arafah M; Department of Pathology, College of Medicine, King Saud University, King Saud University Medical City, Riyadh, 11461, Saudi Arabia., Benabdelkamel H; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia. helkamel@ksu.edu.sa.

Publikováno v: BMC cancer [BMC Cancer] 2024 Jun 20; Vol. 24 (1), pp. 752. Date of Electronic Publication: 2024 Jun 20.

Hemp Seed Oil Inhibits the Adipogenicity of the Differentiation-Induced Human Mesenchymal Stem Cells through Suppressing the Cannabinoid Type 1 (CB1).

Autor: Almousa AS; Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.; Department of Human Nutrition, College of Home Economics, King Khalid University, P.O. Box 3236, Abha 10001, Saudi Arabia., Subash-Babu P; Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia., Alanazi IO; The Healthy Aging Research Institute, King Abdulaziz City for Science and Technology, P.O. Box 6086, Riyadh 11442, Saudi Arabia.; Genome Research Unit, Department of Biochemistry, College of Science, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia., Alshatwi AA; Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia., Alkhalaf H; The Healthy Aging Research Institute, King Abdulaziz City for Science and Technology, P.O. Box 6086, Riyadh 11442, Saudi Arabia., Bahattab E; The Healthy Aging Research Institute, King Abdulaziz City for Science and Technology, P.O. Box 6086, Riyadh 11442, Saudi Arabia., Alsiyah A; The Applied Genomics Research Institute, King Abdulaziz City for Science and Technology, P.O. Box 6086, Riyadh 11442, Saudi Arabia., Alzahrani M; Institute of Advanced Agricultural and Food Technologies, King Abdulaziz City for Science and Technology, P.O. Box 6086, Riyadh 11442, Saudi Arabia.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2024 Mar 31; Vol. 29 (7). Date of Electronic Publication: 2024 Mar 31.

Proteomic Profiling Identifies Distinct Regulation of Proteins in Obese Diabetic Patients Treated with Metformin.

Autor: Alshahrani A; Department of Medicine, Ministry of National Guard Health Affairs, Riyadh 11426, Saudi Arabia.; King Abdullah International Medical Research Center, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia., Aljada A; Department of Biochemistry and Molecular Medicine, College of Medicine, Al Faisal University, Riyadh 11533, Saudi Arabia., Masood A; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi Arabia., Mujammami M; Endocrinology and Diabetes Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.; University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh 11461, Saudi Arabia., Alfadda AA; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi Arabia.; Department of Medicine, College of Medicine and King Saud Medical City, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi Arabia., Musambil M; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi Arabia., Alanazi IO; Healthy Aging Research Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Saudi Arabia., Al Dubayee M; Department of Medicine, Ministry of National Guard Health Affairs, Riyadh 11426, Saudi Arabia.; King Abdullah International Medical Research Center, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia., Abdel Rahman AM; Department of Biochemistry and Molecular Medicine, College of Medicine, Al Faisal University, Riyadh 11533, Saudi Arabia.; Metabolomics Section, Department of Clinical Genomics, Center for Genomics Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 11564, Saudi Arabia., Benabdelkamel H; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi Arabia.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Sep 23; Vol. 16 (10). Date of Electronic Publication: 2023 Sep 23.

Tissue-Based Proteomic Profiling in Patients with Hyperplasia and Endometrial Cancer.

Autor: Akkour K; Obstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia., Alanazi IO; The National Center for Biotechnology (NCB), Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia., Alfadda AA; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.; Department of Medicine, College of Medicine and King Saud Medical City, King Saud University, Riyadh 11461, Saudi Arabia., Alhalal H; Obstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia., Masood A; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia., Musambil M; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia., Rahman AMA; Metabolomics Section, Department of Clinical Genomics, Center for Genome Medicine, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riyadh 11211, Saudi Arabia., Alwehaibi MA; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11461, Saudi Arabia., Arafah M; Department of Pathology, College of Medicine, King Saud University, King Saud University Medical City, Riyadh 11461, Saudi Arabia., Bassi A; Obstetrics and Gynecology Department, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia., Benabdelkamel H; Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.

Publikováno v: Cells [Cells] 2022 Jul 05; Vol. 11 (13). Date of Electronic Publication: 2022 Jul 05.