Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Alana Smith"'
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Akademický článek
MicroRNA29B induces fetal hemoglobin via inhibition of the HBG repressor protein MYB in vitro and in humanized sickle cell mice
Autor: Qingqing Gu, Chithra D. Palani, Alana Smith, Biaori Li, Ernestine Kubi Amos-Abanyie, Ugochi Ogu, Lu Lu, Betty S. Pace, Athena Starlard-Davenport
Publikováno v: Frontiers in Medicine, Vol 9 (2022)
IntroductionTherapeutic strategies aimed at reactivating HBG gene transcription and fetal hemoglobin (HbF) synthesis remain the most effective strategy to ameliorate the clinical symptoms of sickle cell disease (SCD). We previously identified microRN
Externí odkaz: https://doaj.org/article/3189817d1d664ae48d88fec827c903cb
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2
Akademický článek
An Intervention Study: Does a Cognitive Reappraisal Technique Reduce the Perceived Stress in Fourth-Year Dental Students in New Zealand?
Autor: Alana Smith, Imogen Scott, Jithendra Ratnayake, Kate Newsham-West, Peter Cathro
Publikováno v: International Journal of Dentistry, Vol 2019 (2019)
Background. The fourth-year of the Bachelor of Dental Surgery (BDS) degree is considered the most stressful in the curriculum. Cognitive reappraisal is a self-applied method of stress management where an individual recognises his/her physiological re
Externí odkaz: https://doaj.org/article/6e989d8fb4fa4b7dbe1868ac8ed81b05
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3
Characterization of the Metabolome of Breast Tissues from Non-Hispanic Black and Non-Hispanic White Women Reveals Correlations between Microbial Dysbiosis and Enhanced Lipid Metabolism Pathways in Triple-Negative Breast Tumors
Autor: Alana Smith, Xueyuan Cao, Qingqing Gu, Ernestine Kubi Amos-Abanyie, Elizabeth A. Tolley, Gregory Vidal, Beverly Lyn-Cook, Athena Starlard-Davenport
Publikováno v: Cancers; Volume 14; Issue 17; Pages: 4075
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that is non-responsive to hormonal therapies and disproportionately impact women of African ancestry. We previously showed that TN breast tumors have a distinct microbial sig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0f04623bda0adc95c084f627b9cf25
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5
Distinct microbial communities that differ by race, stage, or breast-tumor subtype in breast tissues of non-Hispanic Black and non-Hispanic White women
Autor: Liza Makowski, Alana Smith, Beverly Lyn-Cook, Athena Starlard-Davenport, Elizabeth A. Tolley, Gregory A. Vidal, Joseph F. Pierre, Lu Lu
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Growing evidence highlights an association between an imbalance in the composition and abundance of bacteria in the breast tissue (referred as microbial dysbiosis) and breast cancer in women. However, studies on the breast tissue microbiome have not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084caf0b6fe7aa7a468d2f17563c4b06
http://link.springer.com/article/10.1038/s41598-019-48348-1
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6
MIR29B mediates epigenetic mechanisms of HBG gene activation
Autor: Alana Smith, Athena Starlard-Davenport, Betty S. Pace, Luan Vu, Biaoru Li
Publikováno v: British Journal of Haematology
Summary Sickle cell disease (SCD) affects over 2 million people worldwide with high morbidity and mortality in underdeveloped countries. Therapeutic interventions aimed at reactivating fetal haemoglobin (HbF) is an effective approach for improving su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7fffb1829fed58ff9133857807d588
http://europepmc.org/articles/PMC6589104
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7
Abstract 3022: Tryptophan metabolism is associated with obesity and triple negative breast cancer risk in black and white women
Autor: Alana Smith, Qingqing Gu, Ernestine Kubi Amos-Abanyie, Elizabeth Tolley, Lu Lu, Beverly Lyn-Cook, Athena Starlard-Davenport
Publikováno v: Cancer Research. 82:3022-3022
Non-Hispanic black (NHB) women are more likely to be diagnosed and die from triple negative breast cancer (TNBC) than non-Hispanic white (NHW) women. We previously showed that TNBC tissues display a distinct microbial signature. Obesity which contrib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0f1833cfd7460947feca5b078105af2
https://doi.org/10.1158/1538-7445.am2022-3022
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8
Accessing Alkyl- and Alkenylcyclopentanes from Cr-Catalyzed Ethylene Oligomerization Using 2-Phosphinophosphinine Ligands
Autor: Stephen M. Mansell, Martin J. Hanton, Alana Smith, Robert J. Newland, David M. Smith, Natalie Fey
Publikováno v: Newland, R J, Smith, A, Smith, D M, Fey, N, Hanton, M J & Mansell, S M 2018, ' Accessing Alkyl-and Alkenylcyclopentanes from Cr-Catalyzed Ethylene Oligomerization Using 2-Phosphinophosphinine Ligands ', Organometallics, vol. 37, no. 6, pp. 1062-1073 . https://doi.org/10.1021/acs.organomet.8b00063
Desilylation of the 2-phosphinophosphinine 2-PPh2-3-Me-6-SiMe3-PC5H2 with HCl gave 2-PPh2-3-Me-PC5H3, demonstrating the late-stage modification of this bidentate heterocyclic ligand. Group 6 metal carbonyl complexes of these ligands showed κ2 bindin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2441a3541e1521afb4837171015f4327
https://doi.org/10.1021/acs.organomet.8b00063
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9
Investigation of miRNA-29b As a Fetal Hemoglobin Inducer in Sickle Cell Disease
Autor: Athena Starlard-Davenport, Alana Smith, Qingqing Gu, Umapathy N Siddaramappa, Chithra Palani, Betty S. Pace
Publikováno v: Blood. 138:2023-2023
Introduction: Therapeutic intervention aimed at inducing fetal hemoglobin (HbF) expression is an effective approach for ameliorating the clinical severity of sickle cell disease (SCD). Hydroxyurea (HU) is the only FDA-approved drug with proven effica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38bda58c950e0c4e139070ad7362191a
https://doi.org/10.1182/blood-2021-153290
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10
Abstract 2341: Metabolomic analysis reveals unique biochemical signatures associated with microbial dysbiosis, inflammation and energy metabolism in breast tissues of obese and nonobese black and white breast cancer patients
Autor: Elizabeth A. Tolley, Lu Lu, Athena Starlard-Davenport, Alana Smith
Publikováno v: Cancer Research. 81:2341-2341
Black women are more likely to be diagnosed with late-stage breast cancer than white women and have the lowest probability of cause-specific survival. Obesity is associated with increased breast cancer risk and deaths in black women. Insulin-resistan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::075b76454ebc0654af65c96bb37dd79e
https://doi.org/10.1158/1538-7445.am2021-2341
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