Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alana L Whitcombe"'
Autor:
Joshua Osowicki, MBBS, Kristy I Azzopardi, BSc, Loraine Fabri, MD, Hannah R Frost, PhD, Tania Rivera-Hernandez, PhD, Melanie R Neeland, PhD, Alana L Whitcombe, BSc, Anneke Grobler, PhD, Sarah J Gutman, MBBS, Ciara Baker, MSc, Janet M F Wong, MBBS, Jason D Lickliter, PhD, Claire S Waddington, PhD, Manisha Pandey, PhD, Tibor Schuster, PhD, Allen C Cheng, ProfPhD, Andrew J Pollard, ProfPhD, James S McCarthy, ProfMD, Michael F Good, ProfPhD, James B Dale, ProfMD, Michael Batzloff, PhD, Nicole J Moreland, PhD, Mark J Walker, ProfPhD, Jonathan R Carapetis, ProfPhD, Pierre R Smeesters, ProfPhD, Andrew C Steer, ProfPhD
Publikováno v:
The Lancet Microbe, Vol 2, Iss 7, Pp e291-e299 (2021)
Summary: Background: Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof
Externí odkaz:
https://doaj.org/article/ec41c56b2f5e46caa2cee686d70a813b
Autor:
Alana L Whitcombe, Reuben McGregor, Alyson Craigie, Alex James, Richard Charlewood, Natalie Lorenz, James MJ Dickson, Campbell R Sheen, Barbara Koch, Shivani Fox‐Lewis, Gary McAuliffe, Sally A Roberts, Susan C Morpeth, Susan Taylor, Rachel H Webb, Susan Jack, Arlo Upton, James E Ussher, Nicole J Moreland
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract Objectives Circulating antibodies are important markers of previous infection and immunity. Questions remain with respect to the durability and functionality of SARS‐CoV‐2 antibodies. This study explored antibody responses in recovered C
Externí odkaz:
https://doaj.org/article/cfcf95df2f4b4541a1bc35d2cc9b14fc
Autor:
Natalie Lorenz, Reuben McGregor, Alana L. Whitcombe, Prachi Sharma, Ciara Ramiah, Francis Middleton, Michael G. Baker, William J. Martin, Nigel J. Wilson, Amy W. Chung, Nicole J. Moreland
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110558- (2024)
Summary: Understanding the immune profile of acute rheumatic fever (ARF), a serious post-infectious sequelae of Streptococcal pyogenes (group A Streptococcus [GAS]), could inform disease pathogenesis and management. Circulating cytokines, immunoglobu
Externí odkaz:
https://doaj.org/article/b13c75f917df48d4a74aa75b9fe44bec
Autor:
Reuben McGregor, Alana L. Whitcombe, Campbell R. Sheen, James M. Dickson, Catherine L. Day, Lauren H. Carlton, Prachi Sharma, J. Shaun Lott, Barbara Koch, Julie Bennett, Michael G. Baker, Stephen R. Ritchie, Shivani Fox-Lewis, Susan C. Morpeth, Susan L. Taylor, Sally A. Roberts, Rachel H. Webb, Nicole J. Moreland
Publikováno v:
PeerJ, Vol 8, p e9863 (2020)
Background Serological assays that detect antibodies to SARS-CoV-2 are critical for determining past infection and investigating immune responses in the COVID-19 pandemic. We established ELISA-based immunoassays using locally produced antigens when N
Externí odkaz:
https://doaj.org/article/f4d51d459e1742a5b2037cdfc57a8dd8
Autor:
Thomas Hills, Aimee Paterson, Rebecca Woodward, Francis Middleton, Lauren H. Carlton, Reuben McGregor, Sebastien Barfoot, Ciara Ramiah, Alana L. Whitcombe, Victor M. Zimbron, David Mahuika, Joshua Brown, Kate Palmer-Neels, Brittany Manning, Devanshi Jani, Brooke Reeves, Georgia T. Whitta, Susan Morpeth, Richard Beasley, Mark Weatherall, Anthony Jordan, Peter McIntyre, Nicole J. Moreland, S. Ali Mirjalili
Publikováno v:
Vaccine. 40:4827-4834
The mRNA COVID vaccines are only licensed for intramuscular injection but it is unclear whether successful intramuscular administration is required for immunogenicity.In this observational study, eligible adults receiving their first ComirnatyPartici
Autor:
Alana L Whitcombe, Reuben McGregor, Julie Bennett, Jason K Gurney, Deborah A Williamson, Michael G Baker, Nicole J Moreland
Publikováno v:
The Journal of Infectious Diseases. 226:167-176
Background Group A Streptococcus (GAS) causes superficial pharyngitis and skin infections as well as serious autoimmune sequelae such as acute rheumatic fever (ARF) and subsequent rheumatic heart disease. ARF pathogenesis remains poorly understood. I
Autor:
James S. McCarthy, Alana L. Whitcombe, Melanie R Neeland, Joshua Osowicki, Hannah R Frost, Pierre R. Smeesters, Manisha Pandey, Nicole J. Moreland, Allen C. Cheng, Andrew J. Pollard, Mark J. Walker, Anneke Grobler, Jonathan R. Carapetis, Sarah J. Gutman, James B. Dale, Tibor Schuster, Claire S. Waddington, Michael R. Batzloff, Ciara A Baker, Andrew C Steer, Loraine Fabri, Kristy Azzopardi, Jason D Lickliter, Janet M F Wong, Tania Rivera-Hernandez, Michael F. Good
Publikováno v:
The Lancet Microbe, Vol 2, Iss 7, Pp e291-e299 (2021)
The Lancet Microbe
The Lancet Microbe
Background: Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concep
Autor:
Md S. Bhuiyan, Ben J. Brintz, Alana L. Whitcombe, Alena J. Markmann, Luther A. Bartelt, Nicole J. Moreland, Andrew S. Azman, Daniel T. Leung
Publikováno v:
Epidemiology and Infection
Serosurveillance is an important epidemiologic tool for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), used to estimate infection rates and the degree of population immunity. There is no general agreement on which antibody biomarker(s)
Autor:
Susanne Tritscheller, William John Martin, Jeremy M Raynes, Natalie Lorenz, Timothy Kc Ho, Nigel Wilson, Mei Lin Tay, Alana L. Whitcombe, Amy W. Chung, Reuben McGregor, Nicole J. Moreland, Michael G Baker, Jason Gurney, Deborah A Williamson, Paulina Hanson-Manful, Cristin G. Print, Jane Oliver
Publikováno v:
Immunology & Cell Biology. 98:12-21
Acute rheumatic fever (ARF) and chronic rheumatic heart disease (RHD) are autoimmune sequelae of a Group A streptococcal infection with significant global mortality and poorly understood pathogenesis. Immunoglobulin and complement deposition were obs
Autor:
Thomas Proft, Polly Atatoa Carr, Paul G. Young, Sonia M. McAlister, Stephen R Ritchie, Nicole J. Moreland, Lea-Ann S. Kirkham, Franklin Han, Alana L. Whitcombe
Publikováno v:
Journal of immunological methods. 500
Group A Streptococcus (GAS) is a major human pathogen responsible for superficial infections through to life-threatening invasive disease and the autoimmune sequelae acute rheumatic fever (ARF). Despite a significant global economic and health burden