A methylation risk score for chronic kidney disease: a HyperGEN study

Autor: Alana C. Jones, Amit Patki, Vinodh Srinivasasainagendra, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Nicole D. Armstrong, Ninad S. Chaudhary, Bré Minniefield, Devin Absher, Donna K. Arnett, Leslie A. Lange, Ethan M. Lange, Bessie A. Young, Clarissa J. Diamantidis, Stephen S. Rich, Josyf C. Mychaleckyj, Jerome I. Rotter, Kent D. Taylor, Holly J. Kramer, Russell P. Tracy, Peter Durda, Silva Kasela, Tuuli Lappalinen, Yongmei Liu, W. Craig Johnson, David J. Van Den Berg, Nora Franceschini, Simin Liu, Charles P. Mouton, Parveen Bhatti, Steve Horvath, Eric A. Whitsel, Marguerite R. Irvin

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Chronic kidney disease (CKD) impacts about 1 in 7 adults in the United States, but African Americans (AAs) carry a disproportionately higher burden of disease. Epigenetic modifications, such as DNA methylation at cytosine-phosphate-guanine (

Externí odkaz: https://doaj.org/article/12deb3d0ae334de99921176e9c1f291a

Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas

Autor: Odessica Hughes, Amy R. Bentley, Charles E. Breeze, Francois Aguet, Xiaoguang Xu, Girish Nadkarni, Quan Sun, Bridget M. Lin, Thomas Gilliland, Mariah C. Meyer, Jiawen Du, Laura M. Raffield, Holly Kramer, Robert W. Morton, Mateus H. Gouveia, Elizabeth G. Atkinson, Adan Valladares-Salgado, Niels Wacher-Rodarte, Nicole D. Dueker, Xiuqing Guo, Yang Hai, Adebowale Adeyemo, Lyle G. Best, Jianwen Cai, Guanjie Chen, Michael Chong, Ayo Doumatey, James Eales, Mark O. Goodarzi, Eli Ipp, Marguerite Ryan Irvin, Minzhi Jiang, Alana C. Jones, Charles Kooperberg, Jose E. Krieger, Ethan M. Lange, Matthew B. Lanktree, James P. Lash, Paulo A. Lotufo, Ruth J.F. Loos, Vy Thi Ha My, Jesús Peralta-Romero, Lihong Qi, Leslie J. Raffel, Stephen S. Rich, Erik J. Rodriquez, Eduardo Tarazona-Santos, Kent D. Taylor, Jason G. Umans, Jia Wen, Bessie A. Young, Zhi Yu, Ying Zhang, Yii-Der Ida Chen, Tanja Rundek, Jerome I. Rotter, Miguel Cruz, Myriam Fornage, Maria Fernanda Lima-Costa, Alexandre C. Pereira, Guillaume Paré, Pradeep Natarajan, Shelley A. Cole, April P. Carson, Leslie A. Lange, Yun Li, Eliseo J. Perez-Stable, Ron Do, Fadi J. Charchar, Maciej Tomaszewski, Josyf C. Mychaleckyj, Charles Rotimi, Andrew P. Morris, Nora Franceschini

Publikováno v: Cell Genomics, Vol 4, Iss 1, Pp 100468- (2024)

Summary: Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kidne

Externí odkaz: https://doaj.org/article/975974e930614de28f7b1b95b70b9859

Epigenome-wide association study identifies DNA methylation sites associated with target organ damage in older African Americans

Autor: Farah Ammous, Wei Zhao, Scott M. Ratliff, Minjung Kho, Lulu Shang, Alana C. Jones, Ninad S. Chaudhary, Hemant K. Tiwari, Marguerite R. Irvin, Donna K. Arnett, Thomas H. Mosley, Lawrence F. Bielak, Sharon L.R. Kardia, Xiang Zhou, Jennifer Smith

Publikováno v: Epigenetics, Vol 16, Iss 8, Pp 862-875 (2021)

Target organ damage (TOD) manifests as vascular injuries in the body organ systems associated with long-standing hypertension. DNA methylation in peripheral blood leukocytes can capture inflammatory processes and gene expression changes underlying TO

Externí odkaz: https://doaj.org/article/f7d42a6c52ad4d64aada54db9bae0d93

Abstract MP19: An eGFR Polygenic Score Predicts Chronic Kidney Disease in African Americans

Autor: Alana C Jones, Amit Patki, Vinodh Srinivasasainagendra, Nicole D Armstrong, Ninad S Chaudhary, Bertha Hidalgo, Hemant K Tiwari, Nita Limdi, Donna K Arnett, Leslie Lange, Ethan Lange, Krzysztof Kiryluk, Atlas Khan, Marguerite M Irvin

Publikováno v: Circulation. 147

Chronic kidney disease (CKD) is a risk factor for cardiovascular disease and early death. Genetic factors contribute to CKD, and recently, polygenic scores (PGS) have been developed to quantify risk for complex diseases, such as CKD. However, African

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbbeb005bd31dedd6340f19669d5e17e
https://doi.org/10.1161/circ.147.suppl_1.mp19

Genetic Contributors of Efficacy and Adverse Metabolic Effects of Chlorthalidone in African Americans from the Genetics of Hypertension Associated Treatments (GenHAT) Study

Autor: Nicole D. Armstrong, Vinodh Srinivasasainagendra, Lakshmi Manasa S. Chekka, Nam H. K. Nguyen, Noor A. Nahid, Alana C. Jones, Rikki M. Tanner, Bertha A. Hidalgo, Nita A. Limdi, Steven A. Claas, Yan Gong, Caitrin W. McDonough, Rhonda M. Cooper-DeHoff, Julie A. Johnson, Hemant K. Tiwari, Donna K. Arnett, Marguerite R. Irvin

Publikováno v: Genes; Volume 13; Issue 7; Pages: 1260

Hypertension is a leading risk factor for cardiovascular disease mortality. African Americans (AAs) have the highest prevalence of hypertension in the United States, and to alleviate the burden of hypertension in this population, better control of bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f6f6a24f7fc63b005150c6831affb2
https://pubmed.ncbi.nlm.nih.gov/35886043