Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alan Y. Du"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Transposable elements (TEs) comprise ~50% of our genome, but knowledge of how TEs affect genome evolution remains incomplete. Leveraging ENCODE4 data, we provide the most comprehensive study to date of TE contributions to the regulatory geno
Externí odkaz:
https://doaj.org/article/e54702c720d643f38dd0c835f84214b2
Autor:
Xiaoyu Zhuo, Silas Hsu, Deepak Purushotham, Prashant K Kuntala, Jessica K Harrison, Alan Y Du, Samuel Chen, Daofeng Li, Ting Wang
Publikováno v:
Genome Research. :gr.277550.122
Genome browsers have become an intuitive and critical tool to visualize and analyze genomic features and data. Conventional genome browsers display data/annotations on a single reference genome/assembly; there are also genomic alignment viewer/browse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ac08c49675f5d683f4c6665fcb17f9
https://doi.org/10.1101/gr.277550.122
https://doi.org/10.1101/gr.277550.122
Publikováno v:
Genome Res
Structural variation (SV), including insertions and deletions (indels), is a primary mechanism of genome evolution. However, the mechanism by which SV contributes to epigenome evolution is poorly understood. In this study, we characterized the associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4c8c6a60694bef06333c42b9787d0b
https://doi.org/10.1101/gr.263491.120
https://doi.org/10.1101/gr.263491.120
Autor:
Alan Y. Du, Xiaoyu Zhuo, Vasavi Sundaram, Nicholas O. Jensen, Hemangi G. Chaudhari, Nancy L. Saccone, Barak A. Cohen, Ting Wang
Publikováno v:
Genome research. 32(10)
Many transposable elements (TEs) contain transcription factor binding sites and are implicated as potential regulatory elements. However, TEs are rarely functionally tested for regulatory activity, which in turn limits our understanding of how TE reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75200132c1fa4e47d36370bc33d83967
https://pubmed.ncbi.nlm.nih.gov/36192170
https://pubmed.ncbi.nlm.nih.gov/36192170
Autor:
Alan Y. Du, Xiaoyu Zhuo, Vasavi Sundaram, Nicholas O. Jensen, Hemangi G. Chaudhari, Nancy L. Saccone, Barak A. Cohen, Ting Wang
Many transposable elements (TEs) contain transcription factor binding sites and are implicated as potential regulatory elements. However, TEs are rarely functionally tested for regulatory activity, which in turn limits our understanding of how TE reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db14ea1dcf31868b4879c36a3c04072f
https://doi.org/10.1101/2022.03.16.483999
https://doi.org/10.1101/2022.03.16.483999
Autor:
Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V Avery, Vicky M Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E Boucher, Fabrice F Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L Colon, Daisy D Colón-López, Yolanda Corbett, Gregory J Crowther, Noemi Cowan, Sarah D'Alessandro, Na Le Dang, Michael Delves, Joseph L DeRisi, Alan Y Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T Ferdig, José A Fernández Robledo, David A Fidock, Isabelle Florent, Patrick V T Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M Goldgof, Rajarshi Guha, W Armand Guiguemde, Nil Gural, R Kiplin Guy, Michael A E Hansen, Kirsten K Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T Jensen, Rays H Y Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P Kumar, Dennis E Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N Mfopa, Raj N Misra, Seunghyun Moon, John P Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J Quinn, Christopher A Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J Sullivan, William Sullivan, Sundari Suresh, Brian M Suzuki, Yo Suzuki, S Joshua Swamidass, Donatella Taramelli, Lauve R Y Tchokouaha, Anjo Theron, David Thomas, Kathryn F Tonissen, Simon Townson, Abhai K Tripathi, Valentin Trofimov, Kenneth O Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M Vinetz, Phat Voong Vinh, Hoan Vu, Nao-Aki Watanabe, Kate Weatherby, Pamela M White, Andrew F Wilks, Elizabeth A Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H A Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A Willis
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005763 (2016)
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg
Externí odkaz:
https://doaj.org/article/18b88a00726d44659ebd19c6f7c84d1b
Autor:
Manu Vanaerschot, David A. Fidock, Kerstin Gagaring, Karla P. Godinez-Macias, Jaeson Calla, Yevgeniya Antonova-Koch, Case W. McNamara, Madeline R. Luth, Melanie Wree, Elizabeth A. Winzeler, Sabine Ottilie, Marisa L. Martino, Korina Eribez, David Plouffe, Alan Y. Du, Matthew Abraham
Publikováno v:
ACS Infectious Diseases
Most phenotypic screens aiming to discover new antimalarial chemotypes begin with low cost, high-throughput tests against the asexual blood stage (ABS) of the malaria parasite life cycle. Compounds active against the ABS are then sequentially tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7959fd781960974e52a313b682449f16
https://doi.org/10.1021/acsinfecdis.9b00482
https://doi.org/10.1021/acsinfecdis.9b00482
Autor:
Erica C. Pehrsson, Xiaoyun Xing, Zea Z. Dailey, David M. Zhang, Daofeng Li, Sungsu Kim, David O'Donnell, Ting Wang, Paula M. Godoy, Hyo Sik Jang, Nakul M. Shah, Jeffrey I. Gordon, Alan Y. Du
Publikováno v:
Nature genetics
Transposable elements (TEs) are an abundant and rich genetic resource of regulatory sequences1–3. Cryptic regulatory elements within TEs can be epigenetically reactivated in cancer to influence oncogenesis in a process termed onco-exaptation4. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fa3bf9c6b0d70f735714794cbe2240
https://doi.org/10.1038/s41588-019-0373-3
https://doi.org/10.1038/s41588-019-0373-3
Autor:
Elizabeth A. Winzeler, Stuart L. Schreiber, Bin Zhou, Fengwu Li, Shinji L. Okitsu, Eamon Comer, Stephan Meister, Erika L. Flannery, Kailash P. Patra, David Plouffe, Melanie Wree, Yingyao Zhou, Joseph M. Vinetz, Olga Tanaseichuk, Nobutaka Kato, Kelli Kuhen, Didier Leroy, Christina Scherer, Aristea Lubar, Alan Y. Du
Publikováno v:
Cell host & microbe, vol 19, iss 1
Plouffe, DM; Wree, M; Du, AY; Meister, S; Li, F; Patra, K; et al.(2016). High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission. Cell Host and Microbe, 19(1), 114-126. doi: 10.1016/j.chom.2015.12.001. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2n16396z
Cell Host & Microbe
Plouffe, DM; Wree, M; Du, AY; Meister, S; Li, F; Patra, K; et al.(2016). High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission. Cell Host and Microbe, 19(1), 114-126. doi: 10.1016/j.chom.2015.12.001. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2n16396z
Cell Host & Microbe
Summary Preventing transmission is an important element of malaria control. However, most of the current available methods to assay for malaria transmission blocking are relatively low throughput and cannot be applied to large chemical libraries. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f36299477795ca560cd8048c975bf39
https://doi.org/10.1016/j.chom.2015.12.001
https://doi.org/10.1016/j.chom.2015.12.001
Autor:
Sungsu Kim, Erica C. Pehrsson, Hyo Sik Jang, Zea Z. Dailey, Xiaoyun Xing, David O'Donnell, Alan Y. Du, Jeffrey I. Gordon, Nakul M. Shah, Paula M. Godoy, David M. Zhang, Daofeng Li, Ting Wang
Publikováno v:
Nature Genetics. 51:920-920
In the version of this article initially published, grant PF-17-201-01-TBG from the American Cancer Society to author Erica C. Pehrsson was not included in the Acknowledgements. The error has been corrected in the HTML and PDF versions of the article
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1110d07ad54cd40c503cd0ca137c2eaa
https://doi.org/10.1038/s41588-019-0416-9
https://doi.org/10.1038/s41588-019-0416-9