Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alan Xiangdong Wang"'
Autor:
Eric P. Gillis, Kyle Parcella, Michael Bowsher, James H. Cook, Christiana Iwuagwu, B. Narasimhulu Naidu, Manoj Patel, Kevin Peese, Haichang Huang, Lourdes Valera, Chunfu Wang, Kasia Kieltyka, Dawn D. Parker, Jean Simmermacher, Eric Arnoult, Robert T. Nolte, Liping Wang, John A. Bender, David B. Frennesson, Mark Saulnier, Alan Xiangdong Wang, Nicholas A. Meanwell, Makonen Belema, Umesh Hanumegowda, Susan Jenkins, Mark Krystal, John F. Kadow, Mark Cockett, Robert Fridell
Publikováno v:
Journal of Medicinal Chemistry. 66:1941-1954
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec60862845d7a9e3c5ea18ee8c48c091
https://doi.org/10.1021/acs.jmedchem.2c01732
https://doi.org/10.1021/acs.jmedchem.2c01732
Autor:
Alan Xiangdong Wang, Andrew C. Good, Fei Yu, Peter Hrnciar, Herbert E. Klei, Manjula Paruchuri, Fiona McPhee, Dennis Hernandez, Paul Falk, Jeffrey Tredup, Amy K. Sheaffer, Qi Gao, Barbara Zheng, Kevin Kish, Kathy Mosure, Stanley D'andrea, Ramkumar Rajamani, Alicia Ng, Jay O. Knipe, Yan Chen, Li-Qiang Sun, Jacques Friborg, Paul Michael Scola, Arvind Mathur, Nicholas A. Meanwell, Richard Rampulla
The design and synthesis of potent, tripeptidic acylsulfonamide inhibitors of HCV NS3 protease that contain a difluoromethyl cyclopropyl amino acid at P1 are described. A cocrystal structure of 18 with a NS3/4A protease complex suggests the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb2005e8a0764575ac7a4f49607aedd
https://europepmc.org/articles/PMC5807875/
https://europepmc.org/articles/PMC5807875/
Autor:
Danshi Li, Herbert E. Klei, Sing-Yuen Sit, Piyasena Hewawasam, Ny Sin, Brian Lee Venables, Paul Levesque, Qi Gao, Bilder Donna M, Dennis M. Grasela, Dennis Hernandez, Anthony J. Cocuzza, Amy K. Sheaffer, Richard J. Colonno, Jeffrey Tredup, Kathy Mosure, Stanley D'andrea, Jialong Zhu, Lucy Sun, Fei Yu, Paul Falk, Alan Xiangdong Wang, Steven Levine, Fiona McPhee, Andrew C. Good, Huabin Sun, Jay O. Knipe, Barbara Zheng, Richard Schartman, Nicholas A. Meanwell, Jie Chen, Maria Donoso, James Loy, Guangzhi Zhai, Ramkumar Rajamani, Li-Qiang Sun, Stephen P. Adams, Luciano Mueller, Tatyana Zvyaga, Yong Tu, Hong Shi, Paul Michael Scola, Chaoqun Chen, William Warner, Yan Chen, Yong-Hae Han, Diana Barry, Jacques Friborg, Kevin Kish, Michael Sinz
Publikováno v:
Journal of Medicinal Chemistry. 57:1730-1752
The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor of the NS3/4A enzyme is currently in phase III clinical trials for the treatment of hepatitis C virus infection. The discovery of 24 was enabled by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de12395392456b92810af925e724113
https://doi.org/10.1021/jm500297k
https://doi.org/10.1021/jm500297k
Autor:
Alan Xiangdong Wang, Barbara Zheng, Min S. Lee, Dennis Hernandez, Andrew C. Good, Stanley D'andrea, Amy K. Sheaffer, Fiona McPhee, Christoph Gesenberg, Sing-Yuen Sit, Ny Sin, Paul Falk, Danshi Li, Piyasena Hewawasam, Yan Chen, Yong-Hae Han, Paul Levesque, Brian Lee Venables, Nicholas A. Meanwell, Michael Sinz, Wenying Li, Qi Gao, Li-Qiang Sun, Jay O. Knipe, Chaoqun Chen, Caly Chien, Diana Barry, Guangzhi Zhai, Anthony J. Cocuzza, Tatyana Zvyaga, Stephen P. Adams, Jialong Zhu, Fei Yu, Dennis M. Grasela, Richard J. Colonno, Yong Tu, Ramkumar Rajamani, Herbert E. Klei, Jianqing Li, Min Ding, Jan Willem Thuring, Jie Chen, Susan Jenkins, Keith D. Combrink, Jeffrey Allen Campbell, Kenneth S. Santone, Paul Michael Scola, Eric Hughes, Bilder Donna M
Publikováno v:
Journal of Medicinal Chemistry. 57:1708-1729
The discovery of BMS-605339 (35), a tripeptidic inhibitor of the NS3/4A enzyme, is described. This compound incorporates a cyclopropylacylsulfonamide moiety that was designed to improve the potency of carboxylic acid prototypes through the introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf8154b804898acc5dffe118ba07d84
https://doi.org/10.1021/jm401840s
https://doi.org/10.1021/jm401840s
Autor:
Fei Yu, Dennis Hernandez, Jay O. Knipe, Nicholas A. Meanwell, Paul Michael Scola, Kathy Mosure, Alan Xiangdong Wang, Jie Chen, Danshi Li, Fiona McPhee, Andrew C. Good, Zhao Qian, Li-Qiang Sun, Herbert E. Klei, Jacques Friborg, Paul Levesque, Jialong Zhu, Ramkumar Rajamani
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(3)
The design and synthesis of a series of tripeptide acylsulfonamides as potent inhibitors of the HCV NS3/4A serine protease is described. These analogues house a C4 aryl, C4 hydroxy-proline at the S2 position of the tripeptide scaffold. Information re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7869f6f6bd486adb7521e9648e2d9741
https://pubmed.ncbi.nlm.nih.gov/28011221
https://pubmed.ncbi.nlm.nih.gov/28011221
Autor:
Huabin Sun, Hua Fang, Richard Rampulla, Alan Xiangdong Wang, Bilder Donna M, Bang-Chi Chen, Zhao Qian, Chaoqun Chen, Brian Lee Venables, Fiona McPhee, Jie Chen, Maria Donoso, Barbara Zheng, Paul Falk, Ying-Kai Wang, Yan Chen, Nicholas A. Meanwell, Yong-Hae Han, Qi Gao, Richard Schartman, Luciano Mueller, Steven Levine, Herbert E. Klei, Jacques Friborg, Stephen P. Adams, Ramkumar Rajamani, Anthony J. Cocuzza, Theerthagiri Palani, Dennis M. Grasela, Dennis Hernandez, Fei Yu, Sivakumar Ganesan, James Loy, Tatyana Zvyaga, Paul Levesque, Li-Qiang Sun, Amy K. Sheaffer, Eric Mull, Arvind Mathur, Kathy Mosure, Jeffrey Tredup, Stanley D'andrea, Pirama Nayagam Arunachalam, Jialong Zhu, Mark I. Cockett, Hong Shi, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Jay O. Knipe, Alicia Ng, William Warner, Kevin Kish, Lucy Sun, Michael Sinz, Danshi Li
Publikováno v:
Journal of medicinal chemistry. 59(17)
The discovery of a back-up to the hepatitis C virus NS3 protease inhibitor asunaprevir (2) is described. The objective of this work was the identification of a drug with antiviral properties and toxicology parameters similar to 2, but with a preclini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd2d8cdbd5956b1b7c966304767a031
https://pubmed.ncbi.nlm.nih.gov/27564532
https://pubmed.ncbi.nlm.nih.gov/27564532
Publikováno v:
Synthetic Communications. 39:1264-1272
A convenient and efficient synthetic route to 1-chloro-6-methoxy-isoquinolin-3-ol and its derivatives is reported. This new method involves carboxylation of 4-methoxy-2-methylbenzonitrile, subsequent conversion of the resulting 2-cyano-5-methoxy-phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d669f7073c0a64f2bb17a7e09e35cba
https://doi.org/10.1080/00397910802517889
https://doi.org/10.1080/00397910802517889
Publikováno v:
ChemInform. 40
A convenient and efficient synthetic route to 1-chloro-6-methoxy-isoquinolin-3-ol and its derivatives is reported. This new method involves carboxylation of 4-methoxy-2-methylbenzonitrile, subsequent conversion of the resulting 2-cyano-5-methoxy-phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d1ca79cafc6d8e7a5ed722a01b545ff
https://doi.org/10.1002/chin.200937141
https://doi.org/10.1002/chin.200937141