Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alan X. Xiang"'
Autor:
Peggy A. Thompson, Garrick Kenneth Packard, Theodore Michels, Boreth Eam, Alan X. Xiang, Reich Siegfried Heinz, Sarah Fish, Christian Nilewski, Paul A. Sprengeler, Justin T. Ernst, Christopher J. Wegerski
Publikováno v:
Organic Letters. 22:6257-6261
Rocaglates, rocaglamides, and related flavagline natural products exert their remarkable anticancer activity through inhibition of eukaryotic initiation factor 4A (eIF4A) but generally display suboptimal drug-like properties. In our efforts to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c6c6ced9312dfa787e7deaa5389be5
https://doi.org/10.1021/acs.orglett.0c01944
https://doi.org/10.1021/acs.orglett.0c01944
Autor:
Christian Nilewski, Andres Nevarez, Sarah Fish, Boreth Eam, Alan X. Xiang, Paul A. Sprengeler, Peggy A. Thompson, Jeff Clarine, Garrick Kenneth Packard, Theodore Michels, Reich Siegfried Heinz, Christopher J. Wegerski, Justin T. Ernst, Samuel Sperry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 47:128111
Flavaglines such as silvestrol (1) and rocaglamide (2) constitute an interesting class of natural products with promising anticancer activities. Their mode of action is based on inhibition of eukaryotic initiation factor 4A (eIF4A) dependent translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3ae75bb8babfe7b1170140b02995a4
https://doi.org/10.1016/j.bmcl.2021.128111
https://doi.org/10.1016/j.bmcl.2021.128111
Autor:
Alan X. Xiang, Tran Chinh Viet, Douglas E. Murphy, Yuefen Zhou, Frank Ruebsam, Sun Hee Kim, Kimkim Dao, Lian-Sheng Li, Zhongxiang Sun, Peter S. Dragovich
Publikováno v:
Tetrahedron: Asymmetry. 19:2796-2803
A 4-step synthesis of an optically active synthetic intermediate [(1 R ,2 S )-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with ( S )-(+)-mandelic acid; compound 12 , >99% de] required for the preparation of a promising H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfbc3216e3d6597d5c57d4161151d457
https://doi.org/10.1016/j.tetasy.2008.11.029
https://doi.org/10.1016/j.tetasy.2008.11.029
Autor:
Laurie A. LeBrun, Mei Tsan, Yuefen Zhou, Frank Ruebsam, Darian M. Bartkowski, Alan X. Xiang, Ruhi Kamran, Lian-Sheng Li, Richard E. Showalter, Jingjing Zhao, Rupal Patel, Matthew Lardy, Maria V. Sergeeva, Stephen E. Webber, Amit M. Shah, David Archer Ellis, Zhongxiang Sun, Mcguire Helen, Julie Blazel, Leo Kirkovsky, Daniel A. Norris, Tran Chinh Viet, Charles R. Kissinger, Thomas G. Nolan, Peter S. Dragovich, Qing Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4628-4632
4-(1,1-Dioxo-1,4-dihydro-1lambda(6)-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-one analogs were discovered as a novel class of inhibitors of HCV NS5B polymerase. Structure-based design led to the identification of compound 3a that displayed pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11da5f58198cc1bc858c040e469b8f03
https://doi.org/10.1016/j.bmcl.2008.07.014
https://doi.org/10.1016/j.bmcl.2008.07.014
Autor:
Stephen E. Webber, Amit M. Shah, Kevin R. Steffy, James R. Appleman, Alan X. Xiang, Robert M. Aust, Thomas Doundoulakis, Richard E. Showalter, Klaus B. Simonsen, William T. Biller, Virginia N. Banh, Wes Sisson, Ricardo Lira, Konstantinos A. Agrios
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6797-6800
Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphyloco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cb065632e8fb157a6e76b6add4692a
https://doi.org/10.1016/j.bmcl.2007.10.017
https://doi.org/10.1016/j.bmcl.2007.10.017
Autor:
Alberto, Gobbi, Matthew, Lardy, Sun Hee, Kim, Frank, Ruebsam, Martin, Tran, Stephen E, Webber, Alan X, Xiang
Publikováno v:
In silico biology. 11(1-2)
We present Illuminator, a user-friendly web front end to computational models such as docking and 3D shape similarity calculations. Illuminator was specifically created to allow non-experts to design and submit molecules to computational chemistry pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e79d55c4ace7f86e4acabe5123f1741f
https://pubmed.ncbi.nlm.nih.gov/22475753
https://pubmed.ncbi.nlm.nih.gov/22475753
Publikováno v:
ChemInform. 30
Received July 9, 1998 Clerocidin (1),1 terpentecin (2),2 and UCT4B (3)3 (Figure 1) are recently isolated diterpenoid antibiotics that exhibit very promising antitumor activities in vitro and in vivo.4 It has been postulated that their antitumor prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ec9c0d22aa7caf31ae6caeb41772fd4
https://doi.org/10.1002/chin.199907264
https://doi.org/10.1002/chin.199907264
Publikováno v:
ChemInform. 31
Formation of the C11-C1' bond through application of Barton's radical decarboxylation and quinone addition is the cornerstone of a new convergent and concise synthesis of the marine metabolites avarol (1) and avarone (2; see scheme), for which antimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc1352e15f707c2d5f43ae01794f1fb5
https://doi.org/10.1002/chin.200004254
https://doi.org/10.1002/chin.200004254
Autor:
Tran Chinh Viet, Benjamin K. Ayida, Peter S. Dragovich, Amit M. Shah, Huiying J. Hou, Peggy A. Thompson, Frank Ruebsam, Jingjing Zhao, Rupal Patel, Daniel A. Norris, Ruhi Kamran, Thomas G. Nolan, Stephen E. Webber, Qing Han, Charles R. Kissinger, Alan X. Xiang, Lian-Sheng Li, Darian M. Bartkowski, Jennifer Brooks, Julia Khandurina, Ellen Okamoto, Zhongxiang Sun, Mei Tsan, Laurie A. LeBrun, Mcguire Helen, Julie K. Blazel, Maria V. Sergeeva, Sun Hee Kim, Yuefen Zhou, Douglas E. Murphy, Richard E. Showalter, Leo Kirkovsky
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(22)
A novel series of non-nucleoside small molecules containing a tricyclic dihydropyridinone structural motif was identified as potent HCV NS5B polymerase inhibitors. Driven by structure-based design and building on our previous efforts in related serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae39bb556ac929997f0c827896ab2923
https://pubmed.ncbi.nlm.nih.gov/19818610
https://pubmed.ncbi.nlm.nih.gov/19818610
Autor:
Ruhi Kamran, Tran Chinh Viet, Laurie A. LeBrun, Alberto Gobbi, Jingjing Zhao, David Archer Ellis, Qiang Zhao, Julie Blazel, Rupal Patel, Matthew Lardy, Maria V. Sergeeva, Thomas G. Nolan, Qing Han, Stephen E. Webber, Amit M. Shah, Yuefen Zhou, Frank Ruebsam, Richard E. Showalter, Darian M. Bartkowski, Leo Kirkovsky, Alan X. Xiang, Lian-Sheng Li, Douglas E. Murphy, Mei Tsan, Mcguire Helen, Charles R. Kissinger, Daniel A. Norris
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(21)
The discovery of 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of the HCV RNA-dependent RNA polymerase (NS5B) is described. Several of these agents also display potent antiviral activity in cell culture experiments (EC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32973932e73fbb85f1976aadc3018491
https://pubmed.ncbi.nlm.nih.gov/19796938
https://pubmed.ncbi.nlm.nih.gov/19796938