Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alan W. Varley"'
Autor:
Jintao Feng, Wei Jiang, Xiaofang Cheng, Benkun Zou, Alan W. Varley, Ting Liu, Guojun Qian, Wenjiao Zeng, Jianguo Tang, Qiang Zhao, Yiwei Chu, Yuanyuan Wei, Xiaobo Li, Robert S. Munford, Mingfang Lu
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103004- (2021)
Summary: Although microbe-associated molecular pattern (MAMP) molecules can promote cholesterol accumulation in macrophages, the existence of a host-derived MAMP inactivation mechanism that prevents foam cell formation has not been described. Here, w
Externí odkaz:
https://doaj.org/article/2b9af3614beb4c9a8c9d29bade149939
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2672-2685 (2010)
Macrophages play important roles in both lipid metabolism and innate immunity. We show here that macrophage ATP-binding cassette transporter A1 (ABCA1), a transporter known for its ability to promote apolipoprotein-dependent cholesterol efflux, also
Externí odkaz:
https://doaj.org/article/0d344cb189fa4bbe999027aea4f601ef
Autor:
Yuanyuan Wei, Mingfang Lu, Alan W. Varley, Qiang Zhao, Yiwei Chu, Guojun Qian, Wenjiao Zeng, Jintao Feng, Xiaobo Li, Jianguo Tang, Ting Liu, Robert S. Munford, Xiaofang Cheng, Benkun Zou, Wei Jiang
Publikováno v:
iScience
iScience, Vol 24, Iss 9, Pp 103004-(2021)
iScience, Vol 24, Iss 9, Pp 103004-(2021)
Summary Although microbe-associated molecular pattern (MAMP) molecules can promote cholesterol accumulation in macrophages, the existence of a host-derived MAMP inactivation mechanism that prevents foam cell formation has not been described. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa57be2958f8c049d4d386917d7c2aa2
http://europepmc.org/articles/PMC8426562
http://europepmc.org/articles/PMC8426562
Autor:
Robert S Munford, Alan W Varley
Publikováno v:
PLoS Pathogens, Vol 2, Iss 6, p e67 (2006)
Externí odkaz:
https://doaj.org/article/df9fa06d0a5a4ab9a7be99ec59920633
Publikováno v:
Innate Immunity. 18:825-833
Much evidence indicates that bacterial LPS (endotoxin) is removed from the bloodstream mainly by the liver, yet the hepatic uptake mechanisms remain uncertain and controversial. In plasma, LPS can be either ‘free’ (as aggregates, bacterial membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd36625354458fbfbb9077acf1b77502
https://doi.org/10.1177/1753425912442431
https://doi.org/10.1177/1753425912442431
Autor:
Robert S. Munford, Don C. Rockey, Alan W. Varley, Baomei Shao, Thomas E. Rogers, Richard L. Kitchens
Publikováno v:
Hepatology. 54:1051-1062
Transient hepatomegaly often accompanies acute bacterial infections. Reversible, dose-dependent hepatomegaly also occurs when animals are given intravenous infusions of bacterial lipopolysaccharide (LPS). We found that recovery from LPS-induced hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da68aa8a171011fa4a26e4e7a9a3c89a
https://doi.org/10.1002/hep.24488
https://doi.org/10.1002/hep.24488
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2672-2685 (2010)
Macrophages play important roles in both lipid metabolism and innate immunity. We show here that macrophage ATP-binding cassette transporter A1 (ABCA1), a transporter known for its ability to promote apolipoprotein-dependent cholesterol efflux, also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab4f610d45217573e56cb1c9c324036
https://doi.org/10.1194/jlr.m007435
https://doi.org/10.1194/jlr.m007435
Autor:
Baomei Shao, David R. Greaves, Noredia Ojogun, Robert S. Munford, Tang Yong Kuang, Alan W. Varley
Publikováno v:
The Journal of Infectious Diseases. 200:1685-1693
Although recognition of lipopolysaccharide (LPS) by the myeloid differentiation factor 2-Toll-like receptor 4 complex is important for triggering protective inflammatory responses in animals, terminating many of these responses requires LPS inactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bea2cd406c0710435b6c15d33d17ba
https://doi.org/10.1086/646616
https://doi.org/10.1086/646616
Autor:
Noredia Ojogun, Mingfang Lu, Robert S. Munford, John Hardwick, Donald C. Rockey, Thomas E. Rogers, Alan W. Varley, Steven C. Katz, Baomei Shao, Ronald P. DeMatteo
Publikováno v:
Journal of Biological Chemistry. 282:13726-13735
Much of the inflammatory response of the body to bloodborne Gram-negative bacteria occurs in the liver and spleen, the major organs that remove these bacteria and their lipopolysaccharide (LPS, endotoxin) from the bloodstream. We show here that LPS u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2468d540206ee987492765a1255a18
https://doi.org/10.1074/jbc.m609462200
https://doi.org/10.1074/jbc.m609462200
Publikováno v:
Journal of Endotoxin Research. 5:205-208
Human acyloxyacyl hydrolase is an unusual lipase, found in phagocytic cells, that removes acyl chains from bacterial lipopolysaccharides (LPS) and glycerolipids. It is a heterodimer in which two glycosylated peptides are linked by disulfide bonding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2868c0f75cfe23686efae0b4f2ba542b
https://doi.org/10.1177/09680519990050040701
https://doi.org/10.1177/09680519990050040701