Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alan W. Leung"'
Autor:
Mariia S. Bogacheva, Riina Harjumäki, Emilia Flander, Ara Taalas, Margarita A. Bystriakova, Marjo Yliperttula, Xiaoqiang Xiang, Alan W. Leung, Yan-Ru Lou
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The generation of human stem cell-derived spheroids and organoids represents a major step in solving numerous medical, pharmacological, and biological challenges. Due to the advantages of three-dimensional (3D) cell culture systems and the diverse ap
Externí odkaz:
https://doaj.org/article/6d841bf2d3aa4b51b77f7a6e9c7edadf
Publikováno v:
eLife, Vol 6 (2017)
Neocortical basal radial glia (bRG) and cerebellar Bergmann glia (BG) are basal progenitors derived from ventricular apical radial glia (aRG) that selectively lose their apical processes. bRG and BG have been implicated in the expansion and folding o
Externí odkaz:
https://doaj.org/article/57157398805d440d904c49180d3b2692
Autor:
Ruibang Luo, Law W, Chi-Man Liu, Tong Tm, Luk H, Leung Hc, Lo If, Yan B, Mok Mt, Ou M, Ko Wm, Alan W. Leung, Tak-Wah Lam
HKG is the first fully accessible variant database for Hong Kong Cantonese, constructed from 205 novel whole-exome sequencing data. There has long been a research gap in the understanding of the genetic architecture of southern Chinese subgroups, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7969ff7e460ca1e8835cc61f4e1ba78b
https://doi.org/10.1101/2021.06.15.448515
https://doi.org/10.1101/2021.06.15.448515
Autor:
Ruibang Luo, Yang Liu, Shoudong Zhang, Qingchuan Li, Lina Zhang, Xin Y, Hon-Ming Lam, Alan W. Leung, Shengjie Chen
BackgroundDNA methylation may regulate pre-mRNA transcriptional initiation and processing, thus affecting gene expression. Unlike animal cells, plants, especially Arabidopsis thaliana, have relatively low DNA methylation levels, limiting our ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a5be4cf932ec741cd8fe48bcc47958
https://doi.org/10.1101/2021.04.29.441938
https://doi.org/10.1101/2021.04.29.441938
Autor:
Ruibang Luo, Zheng Z, Alan W. Leung, Lui W, Luk Hm, Tak-Wah Lam, Henry C. M. Leung, Chak-Lim Wong, Lo If
BackgroundThe application of long-read sequencing using the Oxford Nanopore Technologies (ONT) MinION sequencer is getting more diverse in the medical field. Having a high sequencing error of ONT and limited throughput from a single MinION flowcell,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07fa11d88dea0e668390518bba5fde3c
https://doi.org/10.1101/2021.04.05.438455
https://doi.org/10.1101/2021.04.05.438455
Autor:
Alan W. Leung, Cayla Broton, Yan-Ru Lou, Mariia S. Bogacheva, Martín I. García-Castro, Andrew Xiao
Publikováno v:
Journal of molecular biology. 432(13)
Current approaches for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-Associated-9 (Cas9)-mediated genome editing in human pluripotent stem (PS) cells mainly employ plasmids or ribonucleoprotein complexes. Here, we devise a
Autor:
Alan W. Leung, James Y. H. Li
Publikováno v:
The Cerebellum. 17:42-48
Evolution of complex behaviors in higher vertebrates and primates require the development of sophisticated neuronal circuitry and the expansion of brain surface area to accommodate the vast number of neuronal and glial populations. To achieve these g
Autor:
Cayla Broton, Jacqueline C. Hernandez, Kaixuan Lin, Martín I. García-Castro, Alan W. Leung, Andrew Xiao, Maneeshi S. Prasad, Francesc López-Giráldez
SUMMARYWhat are the factors that are induced during the transitory phases from pluripotent stem cells to lineage specified cells, how are they regulated, and what are their functional contributions are fundamental questions for basic developmental bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f3dae4ef10066b77005c5c758500af
Autor:
Alan W. Leung, Patrick B. Shelar, Nabjot Sandhu, Maneeshi S. Prasad, Gustavo A. Gomez, Martín I. García-Castro
Publikováno v:
Developmental biology, vol 449, iss 2
Gomez, Gustavo A; Prasad, Maneeshi S; Sandhu, Nabjot; Shelar, Patrick B; Leung, Alan W; & García-Castro, Martin I. (2019). Human neural crest induction by temporal modulation of WNT activation.. Developmental biology. doi: 10.1016/j.ydbio.2019.02.015. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/25g9c200
Dev Biol
Gomez, Gustavo A; Prasad, Maneeshi S; Sandhu, Nabjot; Shelar, Patrick B; Leung, Alan W; & García-Castro, Martin I. (2019). Human neural crest induction by temporal modulation of WNT activation.. Developmental biology. doi: 10.1016/j.ydbio.2019.02.015. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/25g9c200
Dev Biol
The developmental biology of neural crest cells in humans remains unexplored due to technical and ethical challenges. The use of pluripotent stem cells to model human neural crest development has gained momentum. We recently introduced a rapid chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8d5cd6e42000a37fe3a8e259939bab
https://escholarship.org/uc/item/25g9c200
https://escholarship.org/uc/item/25g9c200
Autor:
Alan W. Leung, Yan-Ru Lou
Publikováno v:
Biotechnology advances. 37(3)