Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Alan W. Douglas"'
Autor:
Benjamin Marcune, Jordan M. Cummins, Ulf-H. Dolling, Leonard William, Alan W. Douglas, Sandor Karady
Publikováno v:
Tetrahedron Letters. 40:6153-6156
Products derived from the homolysis of the aromatic CI bond of ortho -iodobenzophenones by photolysis or tributyltin radicals indicate 1,5-hydrogen migration. The reactions include iodine migration, hydrogen abstraction and arylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da5e56395cbff48fe35bb639e24112d
https://doi.org/10.1016/s0040-4039(99)01292-7
https://doi.org/10.1016/s0040-4039(99)01292-7
Autor:
Nobuyoshi Yasuda, Alan W. Douglas, Mark A. Huffman, Newton L. Abramson, Lyndon C. Xavier, David J. Mathre, Ann E. DeCamp, Edward J. J. Grabowski, Guo Jie Ho, Chunhua Yang, Michael H. Kress, Yulan Li, Sandor Karady, Paul Sohar, Ulf H. Dolling, Khateeta M. Emerson, Fuh-Rong Tsay, Dale L. Rieger, Paul J. Reider
Publikováno v:
The Journal of Organic Chemistry. 63:5438-5446
Anti-MRSA carbapenem, L-742,728, has been prepared in large quantity using the Suzuki−Miyaura cross-coupling as the key reaction. Three approaches have been examined by varying the coupling reaction between carbapenem nucleus A and side chains B, B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb71f403b642d3fc3b1533a63eaa1b3
https://doi.org/10.1021/jo980381n
https://doi.org/10.1021/jo980381n
Publikováno v:
Tetrahedron: Asymmetry. 7:1303-1308
An investigation of the reaction pathway for oxazaborolidine — borane reduction of ketones has revealed a transient intermediate which can competitively reduce ketones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d36c8e556a2f6ae362c98c608f3630a3
https://doi.org/10.1016/0957-4166(96)00147-4
https://doi.org/10.1016/0957-4166(96)00147-4
Autor:
Guo Jie Ho, David L. Hughes, Paul J. Reider, Dalian Zhao, Alan W. Douglas, Mccauley James A, David J. Mathre, Fuh-Rong Tsay, John Y. L. Chung, Robert A. Reamer, Edward J. J. Grabowski, Zhiguo Song, James M. McNamara, Varsolona Richard J
Publikováno v:
The Journal of Organic Chemistry. 61:215-222
A highly practical chromatography-free six-step synthesis of L-734,217 suitable for large scale preparation is described. The key chiral pyridine acid intermediate (R)-1 was prepared in four steps based on a novel chemoselective silyl-mediated conjug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f30ba210a220ebc1209b0f2f0bd22c
https://doi.org/10.1021/jo951214f
https://doi.org/10.1021/jo951214f
Autor:
Laura E. Fredenburgh, Paul J. Reider, Thomas R. Verhoeven, Lisa DiMichele, Bruce S. Foster, Alan W. Douglas, F. Edward Roberts, Ji Liu, Chris H. Senanayake, Robert D. Larsen, Kenneth M. Ryan
Publikováno v:
Tetrahedron Letters. 36:3993-3996
A regio- and stereoselective synthesis of cis-1-aminoindan-2-ol via a Ritter reaction is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f515db689605ae97c7dffc965fdf5501
https://doi.org/10.1016/0040-4039(95)00696-a
https://doi.org/10.1016/0040-4039(95)00696-a
Publikováno v:
Tetrahedron: Asymmetry. 14:3427-3429
Ruthenium–BINAP catalysts are commonly used in asymmetric hydrogenations and provides high enantioselectivity over a wide range of substrates. Herein we focus on a single Ru(II)–BINAP catalyst prepared from cyclooctadienyl ruthenium dichloride an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::804a133610abeee125359a5cf4ddc450
https://doi.org/10.1016/j.tetasy.2003.08.037
https://doi.org/10.1016/j.tetasy.2003.08.037
Autor:
Audrey Molina, Newton L. Abramson, Nobuyoshi Yasuda, Ioannis N. Houpis, Lyndon C. Xavier, Alan W. Douglas, Sandor Karady
Publikováno v:
Tetrahedron Letters. 35:6807-6810
Ortho acylation of anilines by nitriles in the presence of BCl 3 and a second Lewis acid appear to proceed through an intermediate “supercomplex” including all four components. Yield improvements were obtained based on recognition that chloride a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d724291da1fab388f1a2e7ca8682eb
https://doi.org/10.1016/0040-4039(94)85010-0
https://doi.org/10.1016/0040-4039(94)85010-0
Autor:
Audrey Molina, Alan W. Douglas, Ralph P. Volante, Ioannis N. Houpis, Lyndon C. Xavier, Joseph J. Lynch, Paul J. Reider
Publikováno v:
Tetrahedron Letters. 35:6811-6814
The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5609183f358bf2b9d756e816233ef431
https://doi.org/10.1016/0040-4039(94)85011-9
https://doi.org/10.1016/0040-4039(94)85011-9
Autor:
Andrew S. Thompson, Alan W. Douglas, David J. Mathre, Edward J. J. Grabowski, Edward G. Corley, James D. Carroll, Karst Hoogsteen
Publikováno v:
The Journal of Organic Chemistry. 58:2880-2888
A practical, large-scale process for the preparation of tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo-[1,2-c] [1,3,2] oxazaborole-borane is reported. The title compound is a stable, free-flowing crystalline solid useful either stoichiometrically or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb2c1c11aa37404bd5ef65fdc04a54b9
https://doi.org/10.1021/jo00062a037
https://doi.org/10.1021/jo00062a037
Autor:
Alan W. Douglas, Robert A. Reamer, George C. Dezeny, Lawrence F. Colwell, George B. Smith, Lisa DiMichele, Thomas R. Verhoeven
Publikováno v:
Tetrahedron. 49:4447-4462
Autooxidation of the cholesterol-lowering agent simvastatin in ethylene dichloride solution with an azo-type free-radical initiator was investigated in kinetic studies using HPLC. The primary products were oligomers, with peroxide groups within the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8863a1fb94ad4c87652e27536ade1c30
https://doi.org/10.1016/s0040-4020(01)81275-8
https://doi.org/10.1016/s0040-4020(01)81275-8