Mechanisms of Autoantibody-Induced Pathology

Autor: Ralf J. Ludwig, Karen Vanhoorelbeke, Frank Leypoldt, Ziya Kaya, Katja Bieber, Sandra M. McLachlan, Lars Komorowski, Jie Luo, Otavio Cabral-Marques, Christoph M. Hammers, Jon M. Lindstrom, Peter Lamprecht, Andrea Fischer, Gabriela Riemekasten, Claudia Tersteeg, Peter Sondermann, Basil Rapoport, Klaus-Peter Wandinger, Christian Probst, Asmaa El Beidaq, Enno Schmidt, Alan Verkman, Rudolf A. Manz, Falk Nimmerjahn

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves’ disease. Overall, more than 2.5% of the population is affe

Externí odkaz: https://doaj.org/article/ddfdacda2bde42e7bbc8e1baa14cafa2

Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis

Autor: Lhousseine Touqui, Sabrina Noël, Bérengère Villeret, Gilles Crambert, Isabelle Sermet-Gaudelus, Nesrine Baatallah, Aleksander Edelman, Elise Dreano, Emmanuelle Bille, Anita Golec, Aurélie Hatton, Juliette Simonin, Valérie Urbach, Xavier Nassif, Luis J. V. Galietta, Charles-Henry Cottart, Gabrielle Planelles, Alexandre Hinzpeter, Iwona Pranke, Jean-Michel Sallenave, Jean-Patrick Vrel, Aurélie Edwards

Publikováno v: Scientific Reports
Scientific Reports, 2019, 9, pp.6516. ⟨10.1038/s41598-019-42751-4⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-42751-4⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9, pp.6516. ⟨10.1038/s41598-019-42751-4⟩

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized that S. aureus clearance during the first hours of infection was impair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448d0956221b51b11700e76f52392f9a
https://doi.org/10.1038/s41598-019-42751-4