Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alan Van Goethem"'
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Purpose: Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that multiple mechanisms drive resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e9c231d90692706480e995eac2927b
https://doi.org/10.1158/1078-0432.c.6524297
https://doi.org/10.1158/1078-0432.c.6524297
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 9: Summary of Gene Set Enrichment analysis results performed on expression data upon ALK inhibition in 10 cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8ba2b9fbd5cfbaa48dbc06a331da43
https://doi.org/10.1158/1078-0432.22459751.v1
https://doi.org/10.1158/1078-0432.22459751.v1
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 13: Summary of Gene Set Enrichment analysis results obtained on expression profiling data of CLB-Ââ€�GA on different time points (10' - 30'- 60' - 2h - 4h - 6h) after pharmacological inhibition using TAE-Ââ€�684.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25178759ac101de20553303d661c8c67
https://doi.org/10.1158/1078-0432.22459757.v1
https://doi.org/10.1158/1078-0432.22459757.v1
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 1: Cell line information: Summary of the characteristics of cell lines used in this study including origin, tumor type, ALK and MYCN status (wt = wild type, NA = non amplified, A = amplified). Supplemental data 2: GI50 concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3d207cd2c5d9d3ddc79d0dc2c9a918
https://doi.org/10.1158/1078-0432.22459748
https://doi.org/10.1158/1078-0432.22459748
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 5: Differential expression analysis upon ALK inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259ac911c3c0e63378435357663b5dc6
https://doi.org/10.1158/1078-0432.22459754.v1
https://doi.org/10.1158/1078-0432.22459754.v1
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 10: Results of gene ontology analysis performed on the 77 ALK signature genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfa5c6dff8d71b92d2d6595bffe598a
https://doi.org/10.1158/1078-0432.22459763
https://doi.org/10.1158/1078-0432.22459763
Autor:
Katleen De Preter, Frank Speleman, Jorge Vialard, Johannes H. Schulte, Jan Cools, Piotr Zabrocki, Tom Van Maerken, Alan Van Goethem, Nadine Van Roy, Ilse Van Den Wyngaert, David Camacho Trujillo, Junko Takita, Michael Porcu, Glenn M. Marchall, Chris Liang, Geneviève Laureys, Isabelle Janoueix-Lerosey, Jay Gibbons, Olivier Delattre, Sara De Brouwer, An De Bondt, Marilena De Mariano, Belamy B. Cheung, Alex Cazes, Daniel R. Carter, Els Janssens, Anneleen Beckers, Sven Lindner, Shana Claeys, Candy Kumps, Irina Lambertz
Supplemental data 12: Results of Connectivity map analysis performed on ALK signature genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7fe5c3636c7c8b3be7badb7265954b
https://doi.org/10.1158/1078-0432.22459760.v1
https://doi.org/10.1158/1078-0432.22459760.v1
Autor:
Alan Van Goethem, Jill Deleu, Nurten Yigit, Celine Everaert, Myrthala Moreno-Smith, Sanjeev A Vasudevan, Fjoralba Zeka, Fleur Demuynck, Eveline Barbieri, Frank Speleman, Pieter Mestdagh, Jason Shohet, Jo Vandesompele, Tom Van Maerken
Publikováno v:
NAR CANCER
Accurate assessment of treatment response and residual disease is indispensable for the evaluation of cancer treatment efficacy. However, performing tissue biopsies for longitudinal follow-up poses a major challenge in the management of solid tumours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db5116d182701d6347b9cc54e88e877
https://hdl.handle.net/1854/LU-01GQ4PZYZ4ZEY4134GJ5CEX40T
https://hdl.handle.net/1854/LU-01GQ4PZYZ4ZEY4134GJ5CEX40T
Autor:
Shifra Ash, Gudrun Schleiermacher, Frank Berthold, Genevieve Laureys, Joëlle Vermeulen, Valérie Combaret, Tim Lammens, Katrien Vanderheyden, Ana P. Berbegall, Frank Speleman, Hetty Helsmoortel, Jo Vandesompele, Alexander Schramm, Julie Bienertova Vasku, Katleen De Preter, Rosa Noguera, Matthias Fischer, Johannes H. Schulte, Anneleen Decock, Pieter Mestdagh, Sven Rahmann, Marta Jeison, Fjoralba Zeka, Jason M. Shohet, Alan Van Goethem, Mirthala Moreno-Smith, Michael D. Hogarty, Eveline Barbieri, Fleur Demuynck, Pavel Mazánek
In this study, the circulating miRNome from diagnostic neuroblastoma serum was assessed for identification of non-invasive biomarkers with potential in monitoring metastatic disease. After determining the circulating neuroblastoma miRNome, 743 miRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bbb4524beed582c494c622c63a744f
Autor:
Frank Berthold, Frank Speleman, Ana P. Berbegall, Katrien Vanderheyden, Julie Bienertova Vasku, Matthias Fischer, Shifra Ash, Jo Vandesompele, Michael D. Hogarty, Fleur Demuynck, Fjoralba Zeka, Sven Rahmann, Johannes H. Schulte, Joëlle Vermeulen, Marta Jeison, Rosa Noguera, Gudrun Schleiermacher, Jason M. Shohet, Pieter Mestdagh, Genevieve Laureys, Alan Van Goethem, Tom Van Maerken, Eveline Barbieri, Mirthala Moreno-Smith, Anneleen Decock, Katleen De Preter, Hetty Helsmoortel, Alexander Schramm, Valérie Combaret, Pavel Mazánek, Tim Lammens
Publikováno v:
Jci Insight
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
In this study, the circulating miRNome from diagnostic neuroblastoma serum was assessed for identification of noninvasive biomarkers with potential in monitoring metastatic disease. After determining the circulating neuroblastoma miRNome, 743 miRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ed23013cb440a2022a624ff882c1ed
https://www.ncbi.nlm.nih.gov/pubmed/30518699
https://www.ncbi.nlm.nih.gov/pubmed/30518699