Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Alan V Smrcka"'
Publikováno v:
eLife, Vol 8 (2019)
Increased adrenergic tone resulting from cardiovascular stress leads to development of heart failure, in part, through chronic stimulation of β1 adrenergic receptors (βARs) on cardiac myocytes. Blocking these receptors is part of the basis for β-b
Externí odkaz:
https://doaj.org/article/cd20c8c45b644356bdd01626b8b031de
Autor:
Kevin M. Knight, Brian E. Krumm, Nicholas J. Kapolka, W. Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G. Obarow, Tyler J. Lefevre, Wenyuan Wei, Ning Ma, Xi-Ping Huang, Jonathan F. Fay, Nagarajan Vaidehi, Alan V. Smrcka, Paul A. Slesinger, Diomedes E. Logothetis, Kirill A. Martemyanov, Bryan L. Roth, Henrik G. Dohlman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Many neurotransmitter receptors activate G proteins through exchange of GDP for GTP. The intermediate nucleotide-free state has eluded characterization, due largely to its inherent instability. Here we characterize a G protein variant associ
Externí odkaz:
https://doaj.org/article/a1bbb4b8f5a447f79e49586a70a5bd73
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162338 (2016)
The phosphoinositide-specific phospholipase C, PLCε, is a unique signaling protein with known roles in regulating cardiac myocyte growth, astrocyte inflammatory signaling, and tumor formation. PLCε is also expressed in endothelial cells, however it
Externí odkaz:
https://doaj.org/article/d9ef0ba422754e9dbade798d6cff4b29
Autor:
Patrick Martin, Emily A. Kurth, David Budean, Nathalie Momplaisir, Elaine Qu, Jennifer M. Simien, Grace E. Orellana, Chad A. Brautigam, Alan V. Smrcka, Ellinor Haglund
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/a9a20249935744639683fc2f64a8de3e
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
DeNies et al. identify a new mechanism of intracellular GPCR signalling. Using CXC chemokine receptor 4 (CXCR4) as a model, they show that upon stimulation with receptor agonists that not only plasma membrane-localized receptors, but also intracellul
Externí odkaz:
https://doaj.org/article/a0a094837ce448838dbe265fd50519a0
Autor:
Jennifer M. Simien, Grace E. Orellana, Hoa T.N. Phan, Yao Hu, Emily A. Kurth, Christine Ruf, Franz Kricek, Qian Wang, Alan V. Smrcka, Ellinor Haglund
Publikováno v:
The Journal of Physical Chemistry B. 127:2457-2465
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2b2b75349f5bfdd46ef21ba33aff18
https://doi.org/10.1021/acs.jpcb.3c01090
https://doi.org/10.1021/acs.jpcb.3c01090
Autor:
Douglas K. Atchison, Christopher L. O’Connor, Kimber Converso-Baran, Ingrid L. Bergin, Hongyu Zhang, Yu Wang, John R. Hartman, Wenjun Ju, Alan V. Smrcka, Santhi K. Ganesh, Markus Bitzer
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1376-H1387
We describe a novel phenotype by which PLCε deficiency predisposes to aortic valve insufficiency and ascending aortic aneurysm, dissection, and sudden death in the setting of ANG II-mediated hypertension. We demonstrate PLCE1 variants in patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3ec961f1dc2deb9173214edfa62083
https://doi.org/10.1152/ajpheart.00262.2022
https://doi.org/10.1152/ajpheart.00262.2022
Publikováno v:
GPCRs as Therapeutic Targets. :458-520
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdeb97ab2c5a7755753386d1eebe22da
https://doi.org/10.1002/9781119564782.ch14
https://doi.org/10.1002/9781119564782.ch14
Autor:
Wenhui, Wei, Alan V, Smrcka
Publikováno v:
Journal of Cardiovascular Pharmacology. 80:334-341
Adrenergic receptors are critical regulators of cardiac function with profound effects on cardiac output during sympathetic stimulation. Chronic stimulation of the adrenergic system of the heart under conditions of cardiac stress leads to cardiac dys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b109c75fa7958174f14351f77f7c9d
https://doi.org/10.1097/fjc.0000000000001324
https://doi.org/10.1097/fjc.0000000000001324
Autor:
Kyun-Do Kim, Seyeon Bae, Tara Capece, Hristina Nedelkovska, Rafael G. de Rubio, Alan V. Smrcka, Chang-Duk Jun, Woojin Jung, Byeonghak Park, Tae-il Kim, Minsoo Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic contr
Externí odkaz:
https://doaj.org/article/eaff6961123b44e39ab2cbba3d2edb63