Site-to-site peptide transport on a molecular platform using a small-molecule robotic arm†

Autor: Naoyuki Toriumi, Daniel J. Tetlow, Augustinas Markevicius, David A. Leigh, Alan T. L. Lee, Salma Kassem

Publikováno v: Chemical Science
Kassem, S, Lee, A T L, Leigh, D A, Markevicius, A, Tetlow, D J & Toriumi, N 2020, ' Site-to-site peptide transport on a molecular platform using a small-molecule robotic arm ', Chemical Science, vol. 12, no. 6, pp. 2065-2070 . https://doi.org/10.1039/D0SC05906D

Peptides attached to a cysteine hydrazide ‘transporter module’ are transported selectively in either direction between two chemically similar sites on a molecular platform, enabled by the discovery of new operating methods for a molecular transpo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb348c50f2c5e70f1aafbc85251863e6
http://europepmc.org/articles/PMC8179245

Stereodivergent synthesis with a programmable molecular machine

Autor: Alan T. L. Lee, Simone Pisano, Vanesa Marcos, Salma Kassem, Leoni I. Palmer, David A. Leigh

Publikováno v: Kassem, S, Lee, A T L, Leigh, D, Marcos Algaba, V, Palmer, L & Pisano, S 2017, ' Stereodivergent synthesis with a programmable molecular machine ', Nature, vol. 549, pp. 374-378 . https://doi.org/10.1038/nature23677

It has been convincingly argued that molecular machines that manipulate individual atoms, or highly reactive clusters of atoms, with Angstrom precision are unlikely to be realized. However, biological molecular machines routinely position rather less

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b73d67346ed4ad5ac0f15e0b46b1621
https://pure.manchester.ac.uk/ws/files/59918499/AAM_22Sept2017_SynMolRobot_Nature.pdf

Synthesis of antagonists of muscarinic (M3) receptors

Autor: Peter E. Penson, Kenneth J. Broadley, Christine Escargueil, Eric J. Thomas, Alan T. L. Lee, Robin H. Davies

Publikováno v: Collection of Czechoslovak Chemical Communications. 76:781-801

Several α-hydroxyamides with (2,6-dialkoxyphenoxy)methyl substituents have been prepared and their activities as antagonists of the M3 muscarinic receptor in guinea pig ileum have been evaluated. N-{1-[(Phenyl)methyl]piperidin-4-yl}-2-{2-[(2,6-dimet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2986f641ac36efa2efbc91abbdd7805
https://doi.org/10.1135/cccc2011017

Further studies of an approach to a total synthesis of phomactins

Autor: Eric J. Thomas, Madeleine Helliwell, Timothy J. Blackburn, Alan T. L. Lee, Michael J. Kilner

Publikováno v: Tetrahedron Letters. 50:3550-3554

The bicyclic sulfone 28, which has the intact carbon skeleton of phomactins, was prepared using a stereoselective [2,3]-Wittig Still rearrangement, a ytterbium triflate-mediated addition of a vinyllithium reagent to an aldehyde and macrocyclisation v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f687fdf25de0360a71db5a234750e29d
https://doi.org/10.1016/j.tetlet.2009.03.042

Pick-up, transport and release of a molecular cargo using a small-molecule robotic arm

Autor: Salma Kassem, Augustinas Markevicius, Jordi Solà, David A. Leigh, Alan T. L. Lee

Publikováno v: Kassem, S, Lee, A T L, Leigh, D, Augustinas Markevicius & Jordi Solà 2015, ' Pick-up, transport and release of a molecular cargo using a small-molecule robotic arm ', Nature Chemistry, vol. 8, pp. 138-143 . https://doi.org/10.1038/nchem.2410

Modern-day factory assembly lines often feature robots that pick up, reposition and connect components in a programmed manner. The idea of manipulating molecular fragments in a similar way has to date only been explored using biological building bloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9f7ae154b5d47ea418972e04fe81db
https://pubmed.ncbi.nlm.nih.gov/26791889