Zobrazeno 1 - 10 of 40 pro vyhledávání: '"Alan T. Hewson"'
1
Quantification of the bioavailability of riboflavin from foods by use of stable-isotope labels and kinetic modeling
Autor: Rufus Turner, Alan T Hewson, Dave J Hart, Paul Finglas, Hilary J. Powers, Jack R. Dainty, Natalie R Bullock
Publikováno v: The American Journal of Clinical Nutrition. 85:1557-1564
Background: Discrepancies have been reported between estimates of the prevalence of riboflavin deficiency based on intakes of riboflavin and estimates based on measures of riboflavin status. One reason for this may be an overestimate of the bioavaila
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96c985bb931bb94d3351be103d6c9fb
https://doi.org/10.1093/ajcn/85.6.1557
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2
A versatile approach to 3-alkyl and 2,3-dialkylpyrroles
Autor: Ian Burley, Jillian Newton, Biljana Bilic, Alan T. Hewson
Publikováno v: Tetrahedron Letters. 41:8969-8972
A route is described towards N -benzoyl-3-alkyl and N -benzoyl-2,3-dialkyl pyrroles from α-amidoketones via an intramolecular Wittig reaction to afford 4-phenylthio-3-pyrrolines which are then oxidised to the corresponding sulphones and aromatised b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdcbffbfaf9c7a51aa728b35c3eed492
https://doi.org/10.1016/s0040-4039(00)01591-4
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3
Synthesis of the necine base (−)-supinidine from (S )-glutamic acid
Autor: Alan T. Hewson, Douglas Mitchell, Carole M. Boynton
Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :3599-3602
A route is described towards the pyrrolizidine nucleus from derivatives of 5-acetylpyrrolidin-2-one using an intramolecular Wittig reaction with vinylphosphonium salts. The acetoxy ketone 15, derived from (S)-N-benzyloxycarbonylpyroglutamic acid, aff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6910b54a91dbfd3beb2aac9fb1788b4e
https://doi.org/10.1039/b005516f
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4
Enantioselective synthesis of α-bromo acid derivatives and bromohydrins † from tartrate derived bromoacetals
Autor: Scott A. Boyes, Alan T. Hewson
Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :2759-2765
Bromination of the acetals 4 derived from aryl alkyl ketones, ArCOR, and (2R,3R)-tartaric acid results in bromoacetals 5 with 78–90% de. Hydrolysis of those compounds with Ar = 4-methoxyphenyl or 3-bromo-4-methoxyphenyl results, after recrystallisa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ceff17c895ebe92008108c72e348737
https://doi.org/10.1039/b002106g
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5
One-Pot Reduction of Carboxylic Acids via O-Acylisoureas
Autor: James E. Peace, Alan T. Hewson, John M. Herbert
Publikováno v: Synthetic Communications. 28:823-832
A simple one-pot reduction of aliphatic carboxylic acids to primary alcohols, by treatment with dicyclohexylcarbodiimide followed by lithium borohydride, is reported. The same methodology applied to aromatic carboxylic acids is shown to give a mixtur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f66e17d24d825eb7740931dbc7b0b37a
https://doi.org/10.1080/00032719808006479
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7
An unusually facile [3,3]-sigmatropic rearrangement in a stereospecific synthesis of novel 2′,3′-dideoxynucleoside precursors
Autor: Alan T. Hewson, Peter L Armstrong, Martin J. Slater, Iain C Coull
Publikováno v: Tetrahedron Letters. 36:4311-4314
The glycal 5 is converted to intermediates which undergo, under mild conditions, thermal aza-Claisen rearrangements, leading to the amides 7 and 8 and the 2-pyrimidone 9 , all potential precursors to 2′,3′-dideoxynucleosides.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aed26796bca6e69f08a5c0a9afbf0b5
https://doi.org/10.1016/0040-4039(95)00747-z
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8
The Biotransformation and Pharmacokinetics of 14C-Nimesulide in Humans Following a Single Dose Oral Administration
Autor: Simona Parisi, Alan T Hewson, Layla Gedik, Kim D. Rainsford, Stuart A Best, David Macpherson
Publikováno v: Journal of Drug Metabolism & Toxicology.
Nimesulide is a preferential cyclo-oxygenase-2 inhibitory non-steroidal anti-inflammatory drug has, infrequently, been associated with hepatic reactions. To establish the extent of formation of various metabolites (some of which might be hepato-react
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93c2aa83256098bed32d380d1b5b03bc
https://doi.org/10.4172/2157-7609.1000140
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9
Enantiospecific synthesis of 3-pyrrolines: A route to novel polyhydroxylated pyrrolidines
Autor: Ian Burley, Alan T. Hewson
Publikováno v: Tetrahedron Letters. 35:7099-7102
Enantiopure acetamido ketones are converted by an intramolecular Wittig reaction into enantiopure 3-pyrrolines; the product from (S)-serine provides access to novel polyhydroxylated pyrrolidines.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dee6d4fae9e9e7e6b5422cb4d9d628fa
https://doi.org/10.1016/0040-4039(94)88236-3
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