Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Alan Solinger"'
1
Etanercept in adult patients with early onset ankylosing spondylitis
Autor: Robert D, Inman, Daniel O, Clegg, John C, Davis, James B, Whitmore, Alan, Solinger
Publikováno v: The Journal of rheumatology. 33(8)
To determine whether twice-weekly subcutaneous etanercept improves the signs and symptoms of adult patients with early onset ankylosing spondylitis (AS).A retrospective analysis was performed on a subgroup of patients with AS with onset18 years of ag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::050da6a8f230b2f32a31cd27a70fc830
https://pubmed.ncbi.nlm.nih.gov/16881118
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2
A phase 2 dose-finding study of PEGylated recombinant methionyl human soluble tumor necrosis factor type I in patients with rheumatoid arthritis
Autor: Daniel E, Furst, Roy, Fleischmann, Elliott, Kopp, Michael, Schiff, Carl, Edwards, Alan, Solinger, Michael, Macri
Publikováno v: The Journal of rheumatology. 32(12)
In a phase 2 study, to assess the efficacy and safety of pegsunercept, a soluble tumor necrosis factor receptor type I, for the treatment of rheumatoid arthritis (RA).Patients were randomized to receive weekly subcutaneous injections of placebo (n =
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4860dc51b05fcbc998ee4cea1feca1e9
https://pubmed.ncbi.nlm.nih.gov/16331750
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3
Concomitant medication use in a large, international, multicenter, placebo controlled trial of anakinra, a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis
Autor: John, Tesser, Roy, Fleischmann, Robin, Dore, Ralph, Bennett, Alan, Solinger, Tenshang, Joh, Dennis, Modafferi, Joy, Schechtman
Publikováno v: The Journal of rheumatology. 31(4)
To examine the safety of anakinra when added to a background of standard rheumatoid arthritis (RA) medications in patients with RA with active disease.This analysis further evaluates data from the first 6 months of a blinded, placebo controlled safet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8538c299251a8f1b47e7ad5a1be62c9a
https://pubmed.ncbi.nlm.nih.gov/15088288
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4
Immunologic response to the dual murine anti-Id vaccine Melimmune-1 and Melimmune-2 in patients with high-risk melanoma without evidence of systemic disease
Autor: Michael W. Pride, James L. Murray, Albert F. LoBuglio, Mansoor N. Saleh, Alan Solinger, D. Y. Lalisan, Matthew S. Mayo
Publikováno v: Journal of immunotherapy (Hagerstown, Md. : 1997). 21(5)
Melimmune is a dual preparation of two murine anti-idiotypic antibodies (anti-Ids), Melimmune-1 and Melimmune-2, which mimic separate epitopes of the melanoma-associated high molecular weight proteoglycan antigen. In an animal model, vaccination with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6029c4cbe11a0c6e490e3ccd111160
https://pubmed.ncbi.nlm.nih.gov/9789200
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5
Abstract 2449: A novel humanized anti-IL-1beta antibody is highly effective at inhibiting IL-1 induced IL-6 production in myeloma patients in vitro
Autor: John A. Lust, Laurie L. Moon-Tasson, Alan Solinger, Kathleen A. Donovan
Publikováno v: Cancer Research. 70:2449-2449
Background: IL-6 is a central myeloma growth factor and in vitro abnormal production of IL-1beta in the myeloma microenvironment stimulates the generation of paracrine IL-6. Mimicking in vitro observations, we have shown that responsive early stage m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16973bab6b4458bbad1c486d872ccee4
https://doi.org/10.1158/1538-7445.am10-2449
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7
High Affinity Humanized Monoclonal Antibody to Human IL 1β Potently Inhibits Toll-like Receptor (TLR) Agonists in Whole Blood (B61)
Autor: leonid Reznikov, Alan Solinger, charles dinarello
Publikováno v: The Journal of Immunology. 178:LB13-LB13
XOMA 052, a Human Engineered™ monoclonal antibody, was developed to the mature form of human IL-1β following selection from multiple phage display libraries. This antibody has a binding constant for human IL-1β of 300 fM. Human blood cultures wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d2a12e83bd1e2253d99dfc4500b5bdb
https://doi.org/10.4049/jimmunol.178.supp.b61
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8
A Phase 1 Dose Escalation Study of a Fully Human, Antagonist Anti-CD40 Antibody, HCD122 (Formerly CHIR-12.12) in Patients with Relapsed and Refractory Multiple Myeloma
Autor: Sundar Jagannath, Alan Solinger, Sherri Dort, Serge Guzy, Judith A. Fox, William I. Bensinger, Yongyu Wang, Deborah Hurst, Pamela S. Becker, Edward A. Stadtmauer, Sandhya Girish, Sanela Bilic, Lea Aukerman, Kenneth C. Anderson
Publikováno v: Blood. 108:3575-3575
HCD122 is a novel, fully human, IgG1 antagonistic monoclonal antibody targeting the CD40 receptor. This antibody blocks CD40-mediated signaling and is a potent mediator of antibody-dependent cellular cytotoxicity (ADCC). Previous preclinical investig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68cb2fd80cadd285b2dae58f6caf7f92
https://doi.org/10.1182/blood.v108.11.3575.3575
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10
Plasmacytomas and mesothelioma
Autor: Alan Solinger, Mehdi Farhangi, Alan M. Luger, Michael C. Perry
Publikováno v: Medical and Pediatric Oncology. 5:205-212
A patient is reported who developed five plasmacytomas over a four-year period and developed a pleural mesothelioma 12 years later. The relationship of these two entities is discussed and the question of a common environmental carcinogen is raised.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c9400ad1b2c99ac51bc2cd82c1b941
https://doi.org/10.1002/mpo.2950050128
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